|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role and function of granin proteins in diabetes mellitus显示文摘The granin glycoprotein family consists of nine acidic proteins;chromogranin A(CgA),chromogranin B(CgB),and secretogranin II–VIII.They are produced by a wide range of neuronal,neuroendocrine,and endocrine cells throughout the human body.Their major intracellular function is to sort peptides and proteins into secretory granules,but their cleavage products also take part in the extracellular regulation of diverse biological processes.The contribution of granins to carbohydrate metabolism and diabetes mellitus is a recent research area.CgA is associated with glucose homeostasis and the progression of type 1 diabetes.WE-14,CgA10-19,and CgA43-52 are peptide derivates of CgA,and act as CD4+or CD8+autoantigens in type 1 diabetes,whereas pancreastatin(PST)and catestatin have regulatory effects in carbohydrate metabolism.Furthermore,PST is related to gestational and type 2 diabetes.CgB has a crucial role in physiological insulin secretion.Secretogranins II and III have angiogenic activity in diabetic retinopathy(DR),and are novel targets in recent DR studies.Ongoing studies are beginning to investigate the potential use of granin derivatives as drugs to treat diabetes based on the divergent relationships between granins and different types of diabetes. | Zoltan Herold Marton Doleschall Aniko Somogyi | 2021 | World Journal of Diabetes2021，12，7： | 2 |
| 2 | Autonomic and sensory nerve dysfunction in primary biliary cirrhosis显示文摘AIM: Cardiovascular autonomic and peripheral sensory neuropathy is a known complication of chronic alcoholic and non-alcoholic liver diseases. We aimed to assess the prevalence and risk factors for peripheral sensory nerve and autonomic dysfunction using sensitive methods in patients with primary biliary cirrhosis (PBC). METHODS: Twenty-four AMA M2 positive female patients with clinical, biochemical and histological evidence of PBC and 20 age matched healthy female subjects were studied. Five standard cardiovascular reflex tests and 24-h heart rate variability (HRV) analysis were performed to define autonomic function. Peripheral sensory nerve function on median and peroneal nerves was characterized by current perception threshold (CPT), measured by a neuroselective diagnostic stimulator (Neurotron, Baltimore, MD). RESULTS: Fourteen of 24 patients (58%) had at least one abnormal cardiovascular reflex test and thirteen (54%) had peripheral sensory neuropathy. Lower heart rate response to deep breathing (P=0.001), standing (P=0.03) and Valsalva manoeuvre (P=0.01), and more profound decrease of blood pressure after standing (P=0.03) was found in PBC patients than in controls. As a novel finding we proved that both time domain and frequency domain parameters of 24-h HRV were significantly reduced in PBC patients compared to controls. Each patient had at least one abnormal parameter of HRV. Lower CPT values indicated hyperaesthesia as a characteristic feature at peroneal nerve testing at three frequencies (2000 Hz: P=0.005; 250 Hz: P=0.002; 5 Hz: P=0.004) in PBC compared to controls. Correlation of autonomic dysfunction with the severity and duration of the disease was observed. Lower total power of HRV correlated with lower CPT values at median nerve testing at 250 Hz (P = 0.0001) and at 5 Hz (P=0.002), as well as with those at peroneal nerve testing at 2000 Hz (P=0.01). CONCLUSION: Autonomic and sensory nerve dysfunctions are frequent in PBC. Twenty-four-hour HRV analysis is more sensitive than standard cardiovascular tests for detecting of both parasympathetic and sympathetic impairments. Our novel data suggest that hyperaesthesia is a characteristic feature of peripheral sensory neuropathy and might contribute to itching in PBC. Autonomic dysfunction is related to the duration and severity of PBC. | Katalin Keresztes lldikó Istenes Aniko Folhoffer Peter L Lakatos Andrea Horvath Timea Csak Peter Varga Peter Kempler Ferenc Szalay | 2004 | World Journal of Gastroenterology2004，10，20： | 2 |
| 3 | Holmes-Adie syndrome, autoimmune hepatitis and celiac disease: A case report显示文摘与 Holmes-Adie 的下列症状介绍的一个 35 岁的女病人:畏光,对光无答复的左学生的增大,阿奇里斯无反射。毛果芸香硷测试是阳性的。没有肿瘤或另外的神经病学的反常被发现。她有自体免疫的肝炎的 19 年的历史。闪光在上面被观察跟随每 3 交货。在 31 的年龄,她与腹泻和重量损失介绍了。腹的肿瘤被超声检测。通过手术移开的肿瘤是组织学地良性的 mes 伤寒多膀胱的淋巴管瘤。同时,乳糜泻是 diagnosed.Gluten 免费的饮食导致了乳糜泻,然而并非自体免疫的肝炎的重要改进。自治神经病被标准心血管的测试证明。病人是为为乳糜泻特征、为在自体免疫的肝疾病经常的 HLA DR3 B8 异质接合的 HLA DQ2 抗原的一个同型结合的搬运人。我们有自体免疫的肝炎和乳糜泻的 Holmes-Adie 的协会上的新奇观察为为在有 mes 伤寒的一个病人在场的所有三个实体的一个普通免疫学的背景是暗示的多膀胱的淋巴管瘤。 | Timea Csak Aniko Folhoffer Andrea Horvath Judit Halász Csaba Diczházi Zsuzsa Schaff Ferenc Szalay | 2006 | World Journal of Gastroenterology2006，12，9： | 1 |
| 4 | Real-time RT-PCR and SYBR Green I melting curve analysis for the identification of Plum pox virus strains C, EA, and W: Effect of amplicon size, melt rate, and dye translocation 显示文摘 | Aniko Varga Delano James | 2006 | Journal of Virological Methods2006，132，： | 1 |
| 5 | Central Nervous System,Hterus,Heart,and Leukocyte Expression of the LOXL3 Gene,encoding a Novel Lysyl Oxidase-Like Protein显示文摘 | Claude Jourdan-Le Saux Arianne Tomsche Aniko Ujfalusi | 2001 | Genomics2001，74，： | 1 |
| 6 | Genetic algorithms in computer aided design显示文摘 | Gabor Renner Aniko Ekart | 2003 | Computer-Aided Design2003，35，： | 1 |
| 7 | Genetic algorithms in computer aided design 显示文摘 | Gabor R Aniko E | 2003 | Computer Aided Design2003，35，8： | 1 |
| 8 | Genetic Algorithms in Computer Aided Design显示文摘 | Ga'bor Rennera Aniko' Eka'rta | 2003 | Computer-Aided Design2003，35，： | 1 |
| 9 | Relationship between children's social competence, learning motivation and school achievement显示文摘 | Aniko ZI | 2002 | Educational Psy chology2002，，22： | 1 |
| 10 | Relative Contributions of Radiation and Cisplatin-Based Chemotherapy to Sensorineural Hearing Loss in Head-and-Neck Cancer Patients显示文摘 | Ying J. Hitchcock Jonathan D. Tward Aniko Szabo Brandon G. Bentz Dennis C. Shrieve | 2009 | International Journal of Radiation Oncology, Biology, Physics2009，，： | 1 |
| 11 | 显示文摘 | Aniko Borbas Szabo Z I3 Szilagyi Lz | 2002 | Tetrahedron2002，58，： | 1 |
| 12 | Treatment ofmigraine attacks based on the interaction with the trigemino-cerebro-vascular system显示文摘 | Andrea Stephanie Link Aniko Kuris Lars Edvinsson | 2008 | Headache Pain2008，9，1： | 1 |
| 13 | Statistical Modeling for Selecting Housekeeper Genes 显示文摘 | Aniko Szabo Charles M Perou Mehmet Karaca Laurent Perreard John F Quackenbush Philip S Bernard | 2004 | Genome Biology2004，5，8： | 1 |
| 14 | Postischemic spontaneous hyperthermia and its effects in middle cerebral artery occulusion in the rat显示文摘 | Aniko SV Jerome LM | 2000 | Experi Neuro2000，163，： | 1 |
| 15 | A unique combination of plasma membrane Ca^2+-ATPase isoforms is expressed in islets of Langerhans and pancreatic β-cell lines 显示文摘 | Aniko V Elek M Stephen JHA | 1999 | Biochem J1999，314，： | 1 |
| 16 | High-dose N-acetylcysteine for the Prevention of Contrast-induced Nephropathy显示文摘 | Hariprasad Trivedi Sumanth Daram Aniko Szabo Antonio L. Bartorelli Giancarlo Marenzi | 2009 | The American Journal of Medicine2009，，9： | 1 |
| 17 | Relationship Between Children’s Social Competence, Learning Motivation and School Achievement显示文摘 | Aniko Zsolnai | 2002 | Educational Psychology2002，，3： | 1 |
| 18 | Possible influence of neighbours on stereotypic behaviour in horses显示文摘 | Nagy K Aniko S Peter K | 2008 | Appl Anim Behav Sci2008，111，： | 1 |
| 19 | Genetic algorithms in computer aided design显示文摘 | GABOR Renner ANIKO Ekart | 2003 | Computer-Aided Design2003，35，： | 1 |
| 20 | Genetic algorithms in computer aided design显示文摘 | Gabor R Aniko E | 2003 | Computer-Aided Design2003，35，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员