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| 1 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 2 | Structural and molecular features of intestinal strictures in rats with Crohn's-like disease显示文摘AIM: To develop a new rat model we wanted to gain a better understanding of stricture formation in Crohn's disease(CD).METHODS: Chronic colitis was induced locally by the administration of 2,4,6-trinitrobenzenesulfonic acid(TNBS). The relapsing inflammation characteristic to CD was mimicked by repeated TNBS treatments. Animals were randomly divided into control, once, twice and three times TNBS-treated groups. Control animals received an enema of saline. Tissue samples were taken from the strictured colonic segments and also adjacent proximally and distally to its 60, 90 or 120 d after the last TNBS or saline administrations. The frequency and macroscopic extent of the strictures were measured on digital photographs. The structural features of strictured gut wall were studied by light- and electron microscopy. Inflammation related alterations in TGF-beta 2 and 3, matrix metalloproteinases 9(MMP9) and TIMP1 m RNA and protein expression were determined by quantitative real-time PCR and western blot analysis. The quantitative distribution of caspase 9 was determined by post-embedding immunohistochemistry.RESULTS: Intestinal strictures first appeared 60 d after TNBS treatments and the frequency of them increased up to day 120. From day 90 an intact lamina epithelialis, reversible thickening of lamina muscularis mucosae and irreversible thickening of the muscularis externa were demonstrated in the strictured colonic segments. Nevertheless the morphological signs of apoptosis were frequently seen and excess extracellular matrix deposition was recorded between smooth muscle cells(SMCs). Enhanced caspase 9 expression on day 90 in the SMCs and on day 120 also in myenteric neurons indicated the induction of apoptosis. The m RNA expression profile of TGF-betas after repeated TNBS doses was characteristic to CD, TGF-beta 2, but not TGF-beta 3 was up-regulated. Overexpression of MMP9 and down-regulation of TIMP1 were demonstrated. The progressive increase in the amount of MMP9 protein in the strictures was also obvious between days 90 and 120 but TIMP1 protein was practically undetectable at this time.CONCLUSION: These findings indicate that aligned structural and molecular changes in the gut wall rather than neuronal cell death play the primary role in stricture formation. | Petra Talapka Anikó Berkó Lajos István Nagy Lalitha Chandrakumar Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2016 | World Journal of Gastroenterology2016，22，22： | 3 |
| 3 | Electrochemical hydrogen storage capacities of Mg2 Niand MgNi alloys synthesized by mechanical alloying显示文摘 | Anik M | 2010 | Journal of Alloys and Compounds2010，491，12： | 1 |
| 4 | Electrochemical hydrogen storage capacities of Mg2 Ni and MgNi alloys synthesized by mechanical alloying 显示文摘 | ANIK M | 2010 | Journal of Alloys and Compounds2010，491，12： | 1 |
| 5 | Electrochemical hydrogen storage performance of Mg-Ti-Zr-Ni alloys显示文摘 | ANIK M AKAY I O'ZDEMIR G | 2009 | International Journal of Hydrogen Energy2009，34，24： | 1 |
| 6 | Improvements of the electrochemical hydrogen storage performance of Mgz Ni by the partial replacements of Mg by Al, Ti and Zr显示文摘 | ANIK M | 2009 | Journal of Alloys and Compounds2009，486，12： | 1 |
| 7 | Effect of coating bath composi- tion on the properties of electroless Ni- B coatings 显示文摘 | Anik M Korpe E Sen E | 2008 | Surtace ~ Coatings Technology2008，202，9： | 1 |
| 8 | 废弃筒仓变身攀岩健身房——蒙特利尔Allez-Up攀岩健身房显示文摘Allez-Up攀岩健身房是蒙特利尔西南行政区改建项目中的重点项目,该项目位于拉欣运河一侧,原址是老雷德帕思糖厂的筒仓,但如今已被改造成一个室内攀岩健身房,成为运河周边著名的旅游景点和娱乐休闲场所。将废弃的仓库改建成一个攀岩健身房是将蒙特利尔工业时代遗留的建筑的潜能最大化利用的一种独特方法。 | Daniel Smith Karine Renaud Anik Malderis tienne Penault Cindy Neveu Mélanie Quesnel Stéphan Vigeant Stéphane Brugger | 2014 | 设计家2014，，6： | 1 |
| 9 | Synthesis of La2 NiT hydrogen storage alloy by the elec- tro-deoxidation technique显示文摘 | ANIK M AYBAR A B KUCUKDEVECI N | 2015 | International Journal of Hydrogen Energy2015，40，5： | 1 |
| 10 | Hydrogen storage characteristics of Ti2 Ni alloy synthesized by the electro- deoxidation technique 显示文摘 | ANIK M BAKSAN B ORBAY T6 | 2014 | Intermetallics2014，46，： | 1 |
| 11 | Analysis of the electrochemical reaction behavior of alloy AZ91 by EIS technique in H3 PO4/KOH buffered K2 SO4 solutions 显示文摘 | Anik M Celikten G | 2007 | Corro-sion Science2007，49，： | 1 |
| 12 | Analysis of the electrochemical reaction behavior of alloy AZ91 by EIS technique in H3PO4/KOH buffered K2SO4 solutions显示文摘 | Anik M Celikten G | 2007 | Corros Sci2007，49，： | 1 |
| 13 | Superior laryngeal neuralgia after acute laryngitis andtreatment with a single injection of a local anesthetic显示文摘 | Aydin 0 0zturk M Anik Y | 2007 | Arch Otolaryngol HeadNeck Sui-2007，33，9： | 1 |
| 14 | Chloride binding capacity of various hydrated cement paste systems 显示文摘 | Anik D Jacques M Jean-Pierre O | 1997 | Advanced Cement Based Materials1997，6，1： | 1 |
| 15 | Effect of the eutectic phase mixture on the anodic behavior of alloy AZ91显示文摘 | ANIK M AVCI P TANVERDI A CELIKYUREK I BAKSAN B GURLER R | 2006 | Materials and Design2006，27，5： | 1 |
| 16 | Effect of the eutectic phase mixture on the anodic behavior of alloy AZ91显示文摘 | ANIK M AVCI P TANVERDI A CELIKYUREK I BAKSAN B GURLER R | 2006 | Materials and Design2006，27，5： | 1 |
| 17 | Effect of coating bath composition on the properties of electroless nickel- boron films 显示文摘 | Anik M KOrpe E Sen E | 2008 | Surface & Coatings Technology2008，202，： | 1 |
| 18 | Correlating acid properties and catalytic function: a first-principles analysis of alcohol dehydration pathways on polyoxometalates 显示文摘 | J ANIK M J MACHT J IGLESIA E | 2009 | J Phys Chem C2009，113，： | 1 |
| 19 | Examination of the Electroanalytic Performance of Carbon Nanotube (CNT) Modified Carbon Paste Electrodes as Xanthine Biosensor Transducers显示文摘 | Anik U Cubukcu M | 2008 | Turk J Chem2008，32，6： | 1 |
| 20 | Improvement of the electrochemical hydrogen storage performance of Mg2Ni by the partial replacements of Mg by Al,Ti and Zr显示文摘 | Anik M | 2009 | Journal of Alloys and Compounds2009，486，12： | 1 |
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