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| 1 | 七个发达国家卫生系统的领导与治理显示文摘本文运用结构式调查方法,探讨了澳大利亚、英国、德国、荷兰、挪威、瑞典和瑞士七个发达国家卫生系统的领导和治理情况。领导与治理模式包含三项基本职能:优先顺序设置、绩效监管和问责制。各国卫生系统的领导和治理方法存在着显著差异,零散并略显随意。虽然各国在卫生系统的总体目标上达成了共识,但设置优先顺序的途径各不相同。成本效益分析作为设置卫生系统运行优先顺序的一个主要方法被各国加以广泛运用,但并未发挥核心作用。各国虽然处于不同的发展阶段,但绩效监管却能广泛吸收有益意见。问责制特别是在最优方法的不确定性方面,各国之间的差异最大。大多数情况下,市场机制、选举程序、直接经济激励以及专业监督与控制等几种不同问责机制的组合可能更为合适。而且这些机制应与优先顺序设置和绩效监管协调一致。 | Peter C Smith Anders Anell Reinhard Busse Luca Crivelli Judith Healy Anne Karin Lindahl Gert Westert Tobechukwu Kene | 2012 | 中国卫生政策研究2012，5，11： | 13 |
| 2 | Could autophagy dysregulation link neurotropic viruses to Alzheimer’s disease?显示文摘Neurotropic herpesviruses have been associated with the onset and progression of Alzheimer’s disease,a common form of dementia that afflicts a large percentage of elderly individuals.Interestingly,among the neurotropic herpesviruses,herpes simplex virus-1,human herpesvirus-6A,and human herpesvirus-6B have been reported to infect several cell types present in the central nervous system and to dysregulate autophagy,a process required for homeostasis of cells,especially neurons.Indeed autophagosome accumulation,indicating an unbalance between autophagosome formation and autophagosome degradation,has been observed in neurons of Alzheimer’s disease patients and may play a role in the intracellular and extracellular accumulation of amyloidβand in the altered protein tau metabolism.Moreover,herpesvirus infection of central nervous system cells such as glia and microglia can increase the production of oxidant species through the alteration of mitochondrial dynamics and promote inflammation,another hallmark of Alzheimer’s disease.This evidence suggests that it is worth further investigating the role of neurotropic herpesviruses,particularly human herpesvirus-6A/B,in the etiopathogenesis of Alzheimer’s disease. | Maria Anele Romeo Alberto Faggioni Mara Cirone | 2019 | Neural Regeneration Research2019，14，9： | 6 |
| 3 | Preparation of ferric oxide-aluminium oxide carbon nanofiber nanocomposites for ultrasound-assisted dispersive magnetic solid phase extraction of 17-beta estradiol in wastewater显示文摘In this work,Fe3O4-Al2O3@CNFs nanocomposite was synthesised and used as a nanosorbent in the ultrasound-assisted dispersive magnetic solid phase extraction(UA-DMSPE)of 17-beta estradiol(E2)in wastewater samples.The quantification of E2 was achieved using high performance liquid chromatography coupled with diode array detector(HPLC-DAD).Various parameters affecting the efficiency of this sample preparation technique were optimised to achieve excellent sensitivity and high recoveries of E2.Response surface methodology was utilised for optimisation of these parameters.Using the optimised conditions,the linear dynamic range was achieved in the range of 0.1e1000 mgL^-1and the correlation coefficient was found to be 0.9981.The preconcentration factor,enrichment factor,limit of detection(LOD)and limit of quantification(LOQ)were 67,169,0.025 mgL^-1and 0.083 mg L1,respectively.The relative standard deviation(%RSD)for the intraday(n?10)and interday(n?5 working days)were 1.8%and 3.3%,respectively.The developed UA-DMSPE/HPLC-DAD method was applied for the preconcentration and determination of E2 in wastewater samples.The obtained results indicated that E2 was present in the wastewater samples. | Malesela William Lekota Anele Mpupa K.Mogolodi Dimpe Philiswa N.Nomngongo | 2020 | Emerging Contaminants2020，6，1： | 3 |
| 4 | The biology of cytotoxic cell granule exoeytosis pathway:granzymes have evolved to induce cell death and inflammation显示文摘 | Pardo J Aguilo JI Anel A | 2009 | Microbes Infect2009，11，4： | 1 |
| 5 | Priority Disputes in Science in the Context of Conflicting Norms:The Case of Isaac Newton and Gottfried Leibniz Revisited显示文摘 | Douglas I. O. Anele | 2011 | Journal of Philosophy Study2011，1，5： | 1 |
| 6 | Protein Kinase C-0 (PKC- 0) in Natural Killer Cell Function and Anti-Tumor Immunity 显示文摘 | Anel A Aguile JI Catalrn E | 2012 | Front Immuno12012，3，： | 1 |
| 7 | Globalization,industrializationand urbanization in pre-world war ii southeast asia显示文摘 | GREGG HUFF LUIS ANELES | 2011 | Exploration in Economic History2011，，1： | 1 |
| 8 | Neonatal and 5-year outcomes after birth at 30-34 weeks of gestation 显示文摘 | Marret S Anell PY Marpean L | 2007 | Ob- stet Gyneco12007，110，1： | 1 |
| 9 | Effects of bulk density of steam-flaked corn in diets containing wet corn gluten feed on feedlot cattle performance,carcass characteristics,apparent total tract digestibility,and ruminal fermentation显示文摘 | Ponce C H Domby E M Anele U Y | 2013 | Journal of Animal Science2013，91，7： | 1 |
| 10 | Pulmonary artery occlusion pres- sure and central venous pressure fail to predict ventricular filling vol- ume, cardiac performance, or the response to volume infusion in nor- real subjects 显示文摘 | Kumar A Anel R Bunnell E | 2004 | Crit CareMed2004，32，3： | 1 |
| 11 | Field and in vitro assay of three methods for freezing ram semen 显示文摘 | ANEL L De PAZ P ALVAREZ M | 2003 | Theriogenology2003，60，7： | 1 |
| 12 | Effect of external cryoprotectants as membrane stabilizers on cryopreserved rainbow trout sperm显示文摘 | Cabrita E AnelL Herraez M P | 2001 | Theriogenology2001，56，4： | 1 |
| 13 | Doxorubicin treatment activates a Z - VAD - sensitive caspase, which causes deltapsim loss, caspase- 9 activity, and apoptosis in Jurkat cell显示文摘 | Gamen S Anel A Perez - Galan P | 2000 | Exp Cell Res2000，258，1： | 1 |
| 14 | Rosuvastatin and Metformin Decrease Inflammation and Oxidative Stress in Patients With Hypertension and Dyslipidemia显示文摘 | Anel Gomez-Garcia Gloria Martinez Torres Luz E Ortega-Pierres | | 0，，12： | 1 |
| 15 | PNA array technology in molecular diagnostics显示文摘 | Albert G Anel Jorg K | 1998 | Nucleosides&Nucleotides1998，17，9： | 1 |
| 16 | Seminal plasma improves cryopreservation of Iberian red deer epididymal sperm 显示文摘 | Martfnez - Pastor F Anel L Guerra C | 2006 | Theriogenology2006，66，： | 1 |
| 17 | CD59 cross-linking induces secretion of APO2 ligand in overactivated human T cells 显示文摘 | Monleon I Martinez-Lorenzo M J Anel A | 2000 | Eur J Immunol2000，30，4： | 1 |
| 18 | Targeting the Apo2L/TRAIL system for the therapy of autoimmune dis-eases and cancer显示文摘 | Martinez-Lostao L Marzo I Anel A | 2012 | Biochem Pharmacol2012，83，11： | 1 |
| 19 | Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects显示文摘 | Kumar A Anel R Bunnell E | 2004 | Crit Care Med2004，32，3： | 1 |
| 20 | Effect of external cryoprtectants as membrane stabilizers on cryopre- served rainbow trout sperm 显示文摘 | Cabrita E Anel L Herraez M P | 2001 | Theriogenology2001，56，4： | 1 |
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