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| 1 | Single-stage tubular urethral reconstruction using oral grafts is an alternative to classical staged approach for selected penile urethral strictures显示文摘Penile urethral strictures have been managed by a staged surgical approach.In selected cases,spongiofibrosis can be excised,a neo-urethral plate created using buccal mucosa graft(BMG)and tubularized during the same procedure,performing a“twoin-one”stage approach.We aim to identify stricture factors which indicate suitability for this two-in-one stage approach.We assess surgical outcome and compare with staged reconstruction.We conducted an observational descriptive study.The data were prospectively collected from two-in-one stage and staged penile urethroplasties using BMG in a single center between 2007 and 2017.The minimum follow-up was 6 months.Outcomes were assessed clinically,radiologically,and by flow-rate analysis.Failure was defined as recurrent stricture or any subsequent surgical or endoscopic intervention.Descriptive analysis of stricture characteristics and statistical comparison was made between groups.Of 425 penile urethroplasties,139 met the inclusion criteria:59 two-in-one stage and 80 staged.The mean stricture length was 2.8 cm(single stage)and 4.5 cm(staged).Etiology was lichen sclerosus(LS)52.5%(single stage)and 73.8%hypospadias related(staged).40.7%of patients had previous failed urethroplasties in the single-stage group and 81.2%in the staged.The most common stricture locations were navicular fossa(39.0%)and distal penile urethra(59.3%)in the single-stage group and mid or proximal penile urethra(58.7%)in the staged group.Success rates were 89.8%(single stage)and 81.3%(staged).A trend toward a single-stage approach for select penile urethral strictures was noted.We conclude that a single-stage substitution penile urethroplasty using BMG as a“two-in-one”approach is associated with excellent functional outcomes.The most suitable strictures for this approach are distal,primary,and LS-related strictures. | Felix Campos-Juanatey Simon Bugeja Mariya Dragova Anastasia V Frost Stella L Ivaz Daniela E Andrich Anthony R Mundy | 2020 | Asian Journal of Andrology2020，22，2： | 1 |
| 2 | Urea degradation in some white wines by immobilized acid urease in a stirred bioreactor 显示文摘 | Andrich L Esti M Moresi M | 2010 | Journal of Agricultural and Food Chemistry2010，58，11： | 1 |
| 3 | Urea degradation kinetics in model wine solutions by acid urease immobilised onto chitosan-derivative beads of different sizes显示文摘 | Andrich L Esti M Moresi M | 2010 | Enzyme and Microbial Technology2010，46，： | 1 |
| 4 | Urea degradation kinetics in model wine solutions by acid urease immobilised onto ehitosan-derivative beads of different sizes 显示文摘 | Andrich L Esti M Moresi M | 2010 | Enzyme Microb Tech2010，46，5： | 1 |
| 5 | Randomized Trials of the Cardioprotective Agent ICRF-187 in Pediatric Sarcoma Patients Treated with Doxorubicin显示文摘 | Wexler L H Andrich M P Venzon D | 1996 | J Clin Oncol1996，14，： | 1 |
| 6 | Urea degradation kinetics inmodel wine solutions by acid urease immobilised onto chitosan-derivative beads of different sizes显示文摘 | ANDRICH L ESTI M MORESI M | 2010 | Enzyme and MicrobialTechnology2010，46，5： | 1 |
| 7 | Management of penile urethral strictures: Challenges and future directions显示文摘The anatomy of the penile urethra presents additional challenges when compared to other urethral segments during open stricture surgery particularly because of its unsuitability for excision and primary anastomosis and its relatively deficient corpus spongiosum. Stricture aetiology, location, length and previous surgical intervention remain the primary factors influencing the choice of penile urethroplasty technique. We have identified what we feel are the most important challenges and controversies in penile urethral stricture reconstruction, namely the use of flaps vs grafts, use of skin or oral mucosal tissue for augmentation/substitution and when a single or a staged approach is indicated to give the best possible outcome. The management of more complex cases such as panurethral lichen-sclerosus strictures and hypospadias 'cripples' is outlined and potential developments for the future are presented. | Felix Campos-Juanatey Simon Bugeja Stella L Ivaz Anastasia Frost Daniela E Andrich Anthony R Mundy | 2016 | World Journal of Clinical Urology2016，5，1： | 0 |
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