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| 1 | Melatonin attenuates high fat diet-induced fatty liver disease in rats显示文摘AIM:To investigate melatonin's preventive action in oxidative stress in a rat model with high fat diet-induced non-alcoholic fatty liver disease(NAFLD).METHODS:NAFLD was induced by high fat diet(HFD)in adult,male,Wistar rats,weighing 180-230 g.After acclimatization for one week,they were randomly assigned to 6 experimental groups that comprised animals on regular diet plus 5 or 10 mg/kg melatonin,for 4 or 8 wk;animals on HFD,with or without 5 or 10 mg/kg melatonin,for 4 or 8 wk;and animals on HFD for 8 or 12 wk,with melatonin 10 mg/kg for the last 4 wk.Liver damage was assessed biochemically by the serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and histologically.Lipid peroxidation and oxidative stress were assessed by malondialdehyde and glutathione levels in liver tissue.Lipidemic indices and portal vein pressure were also measured.RESULTS:Compared to rats not receiving melatonin,rats on 5 or 10 mg/kg of melatonin had lower mean liver weight(-5.0 g and-4.9 g)(P < 0.001)and lower liver weight to body weight ratio(-1.0%)(P < 0.001),for the two doses,respectively.All rats fed HFD without melatonin developed severe,grade Ⅲ,steatosis.Rats on HFD with concurrent use of melatonin showed significantly less steatosis,with grade Ⅲ steatosis observed in 1 of 29(3.4%)rats on 10 mg/kg melatonin and in 3 of 27(11.1%)rats on 5 mg/kg melatonin.Melatonin was ineffective in reversing established steatosis.Melatonin also had no effect on any of the common lipidemic serum markers,the levels of which did not differ significantly among the rats on HFD,irrespective of the use or not of melatonin.Liver cell necrosis was significantly less in rats on HFD receiving melatonin than in those not on melatonin,with the AST levels declining by a mean of 170 U/L(P = 0.01)and 224 U/L(P = 0.001),and the ALT levels declining by a mean of 62.9 U/L(P = 0.01)and 93.4 U/L(P < 0.001),for the 5 and 10 mg/kg melatonin dose,respectively.Melatonin mitigated liver damage due to peroxidation and oxidative stress in liver tissue as indicated by a significant decline in MDA production by 12.7(P < 0.001)and 12.2(P < 0.001)μmol/L/mg protein/mg tissue,and a significant increase in glutathione by 20.1(P = 0.004)and 29.2(P < 0.001)μmol/L/mg protein/mg tissue,for the 5 and 10 mg/kg melatonin dose,respectively.CONCLUSION:Melatonin can attenuate oxidative stress,lessen liver damage,and improve liver histology in rats with high fat diet-induced NAFLD,when given concurrently with the diet. | Gregorios Hatzis Panayiotis Ziakas Nikolaos Kavantzas Aggeliki Triantafyllou Panagiotis Sigalas Ioanna Andreadou Konstantinos Ioannidis Stamatios Chatzis Konstantinos Filis Alexandros Papalampros Fragiska Sigala | 2013 | World Journal of Hepatology2013，5，4： | 4 |
| 2 | Increased levels of circulating platelet-derived microparticles in psoriasis:Possible implications for the associated cardiovascular risk显示文摘AIM To evaluate platelet activation markers in psoriasis patients, compared to controls, and investigate their association with the inflammatory burden of psoriasis.METHODS Forty psoriatic patients without cardiovascular disease,and 12 healthy controls were subjected to measurement of baseline platelet CD62 P, CD63 and CD42 b expression, platelet-leukocyte complexes, i.e., platelet-monocyte complexes(PMC), platelet-neutrophil complexes(PNC) and platelet-lymphocyte complexes, and concentrations of platelet-derived microparticles(PMPs) using flow cytometry. Both larger-size(0.5-0.9 μm) and smallersize(< 0.5 μm) PMPs were determined. Serum interleukin(IL)-12 and IL-17 levels were also measured by enzyme-linked immunosorbent assay. The severity of psoriasis was evaluated by the Psoriasis Area Severity Index(PASI).RESULTS PMP concentrations were significantly higher in psoriasis patients than controls [mean±standard error of mean(SEM): 22±5/μL vs 11±6/μL; P=0.018), for both smaller-size(10±2/μL vs 4±2/μL; P=0.033) and larger-size(12±3/μL vs 6±4/μL; P=0.014) PMPs. Platelet CD62 P, CD63 and CD42 b expression and circulating PMC and PNC were similar between the two groups. Lower circulating PLC were observed in psoriasis patients compared to controls(mean±SEM: 16%±3% vs 23%±6%; P=0.047). Larger-size PMPs were related with IL-12 levels(P<0.001) and smaller-size PMPs with both IL-12 and IL-17 levels(P<0.001). Total PMPs also correlated with IL-12(P<0.001). CD63 expression was positively correlated with both IL-12 and IL-17(P<0.05). Increased PASI score was associated with increased levels of larger-size PMPs(r=0.45; P=0.011) and increased CD63 expression(r=0.47; P<0.01).CONCLUSION PMPs, known to be predictive of cardiovascular outcomes, are increased in psoriasis patients, and associated with high inflammatory disease burden. Enhanced platelet activation may be the missing link leading to cardiovascular events in psoriatic patients. | Evangelia Papadavid Konstantina Diamanti Aris Spathis Maria Varoudi Ioanna Andreadou Kostas Gravanis Kostas Theodoropoulos Petros Karakitsos John Lekakis Dimitrios Rigopoulos Ignatios Ikonomidis | 2016 | World Journal of Cardiology2016，8，11： | 2 |
| 3 | Investigating the signal transduction pathways underlying remote ischemic conditioning in the porcine heart 显示文摘 | Hausenloy DJ Iliodromitis EK Andreadou I | 2012 | Cardiovasc Drugs Ther2012，26，2： | 1 |
| 4 | To prevent, protect and save the ischemic heart: antioxidants revisited 显示文摘 | Andreadou I lliodromitis E K Farmakis D | 2009 | Expert Opin Ther Targets2009，13，8： | 1 |
| 5 | The Ca^2+ sensitizer levosimendan improve oxidagtive damage,BNP and pro-inflammatory cytokine level in patients with advanced decompensated heart failure in comparison to dobutamine显示文摘 | Avgeeropoulon Andreadou I | 2005 | Eur J Heart Fail2005，7，5： | 1 |
| 6 | Familial asymmetric distal upper limb amyotrophy (Hirayama disease): report of a Greek family 显示文摘 | Andreadou E Christodoulou K Manta P | 2009 | Neurologist2009，15，3： | 1 |
| 7 | Simvastatin in con- trast to postconditioning reduces ixffarct size in hyperlipidemic rab- bits :possible role of oxidative/nitrosative stress attenuation显示文摘 | Ili0dromitis EK Andreadou I Prekovas E | 2010 | Basic Res Cardio12010，105，2： | 1 |
| 8 | To prevent,protect and save the ischemic heart:antioxidants revisited显示文摘 | Andreadou I Iliodromitis EK Farmakis D | 2009 | Expert Opin Ther Targets2009，13，8： | 1 |
| 9 | Novel biologic mecha- nisms of levosimendan and its effect on the failing heart 显示文摘 | Parissis JT Andreadou I Bistola V | 2008 | Expert Opin Investig Drugs2008，17，： | 1 |
| 10 | Effects of Darbepoetin Alfa on plasma mediators of oxidative and nitrosative stress in anemic patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy 显示文摘 | Parissis JT Kourea K Andreadou I | 2009 | Am J Cardiol2009，103，8： | 1 |
| 11 | Serum uric acid levels in patients with Parkinson's disease: their relationship to treatment and disease duration 显示文摘 | Andreadou E Nikolaou C Goumaras F | 2009 | Clin Neurol Neurosurg2009，111，9： | 1 |
| 12 | Novel biologic mechanisms of levosimendan and its effect on the failing heart 显示文摘 | Parissis JT Andreadou I Bistola V | 2008 | Expert OpinInvestig Drugs2008，17，8： | 1 |
| 13 | A novel an-tioxidant non-steroidal anti-inflammatory agent protects rat liver against ischemia-reperfusion injury显示文摘 | Leventis I Andreadou I Papalois A | 2004 | In Vi-vo2004，18，2： | 1 |
| 14 | Serum uric acid levels in patients with Parkinson's disease their rela- tionship to treatment and disease duration显示文摘 | ANDREADOU E NIKOLAOU C GOUMARAS F | 2009 | Clin Neurol Nem''n- surg2009，111，9： | 1 |
| 15 | The olive constit- uent oleuropein exhibits anti-ischemic, antioxidative, and hypo- lipidemic effects in anesthetized rabbits 显示文摘 | Andreadou I Iliodromifis E K Mikros E | 2006 | J Nutr2006，136，8： | 1 |
| 16 | To prevent,protect and save the ischemie heart: antioxidants revisited显示文摘 | Andreadou I Iliodromitis EK Farmakis D | 2009 | Expert Opin Ther Targets2009，13，8： | 1 |
| 17 | 1H NMR-Based metabonomics approach in a rat model of acute liver injury and regeneration induced by CCl4administration显示文摘 | Zira A Kostidis S Theocharis S Sigala F Engelsen SB Andreadou I | 2013 | Toxicology2013，303，： | 1 |
| 18 | Effects of levosimendan on circulating markers of oxidative and nitrosative stress in patients with advanced heart failure 显示文摘 | Parissis JT Andreadou I Markantonis SL | 2007 | Atherosclerosis2007，195，2： | 1 |
| 19 | Activating NK cell receptor expression/function (NKp30, NKp46, DNAM‐1) during chronic viraemic HCV infection is associated with the outcome of combined treatment显示文摘 | FedericaBozzano AntoninoPicciotto PaolaCosta FrancescoMarras ValentinaFazio IvanHirsch DanielOlive LorenzoMoretta AndreaDe Maria | 2011 | Eur J Immunol2011，，10： | 1 |
| 20 | The effects of tirofiban on peripheral markers of oxidative stress and endothelial dysfunction in patients with acute coronary syndromes 显示文摘 | ILIODROMITIS E K ANDREADOU I MARKANTONIS- KYROUDIS S | 2007 | Thromb Res2007，119，2： | 1 |
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