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2篇 您的检索式:作者名="Andrea Remuzzi"
    题名 作者 年代 出处 被引量
1WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Mesenchymal stem cells help pancreatic islet transplantation to control type 1 diabetes显示文摘Islet cell transplantation has therapeutic potential to treat type 1 diabetes,which is characterized by autoimmune destruction of insulin-producing pancreatic isletβcells.It represents a minimal invasive approach forβcell replacement,but long-term blood control is still largely unachievable.This phenomenon can be attributed to the lack of islet vasculature and hypoxic environment in the immediate post-transplantation period that contributes to the acute loss of islets by ischemia.Moreover,graft failures continue to occur because of immunological rejection,despite the use of potent immunosuppressive agents.Mesenchymal stem cells(MSCs)have the potential to enhance islet transplantation by suppressing inflammatory damage and immune mediated rejection.In this review we discuss the impact of MSCs on islet transplantation and focus on the potential role of MSCs in protecting islet grafts from early graft failure and from autoimmune attack.Marina Figliuzzi Barbara Bonandrini Sara Silvani Andrea Remuzzi 2014World Journal of Stem Cells2014,6,2:10
2胰岛细胞移植的时机显示文摘一些研究明确指出,成熟的胰岛B细胞有潜在的增殖能力。最近,Nir及其同事进行的一项实验明确提示,胰岛B细胞也可在高血糖环境中增殖。研究者把胰岛B细胞中能表达四环素调控的反式激活子(rtTA)的转基因小鼠与在rtTA反应性启动子的作用下可表达白喉毒素-A亚基的菌株联合起来。在给予多西环素后,rtTA诱导的白喉毒素的表达可引起80%的B细胞凋亡、胰岛素缺乏及高血糖。Piero Ruggenenti Andrea Remuzzi Giuseppe Remuzzi 邓蕾(译) 2008世界临床医学2008,2,5:0
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