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| 1 | Construction of an intrahepatic portosystemic shunt using the magnetic compression technique: preliminary experiments in a canine model显示文摘Portal hypertension caused by liver cirrhosis due to hepatitis is a common clinical condition that can cause bleeding from esophageal and gastric varices in severe cases.In 1969,Rösch et al.first described a successful transjugular intrahepatic portosystemic shunt(TIPS)in animal experiments(1).In 1989,Richter et al.first used this technology in clinical practice(2). | Miaomiao Zhang Jia Ma Yingfeng An Yi Lyu Xiaopeng Yan | 2022 | Hepatobiliary Surgery and Nutrition2022，11，4： | 5 |
| 2 | An e-quality control model for multistage machining processes of workpieces显示文摘To track and control the changes of process quality attributes in multistage machining processes(MMPs),an e-quality control(e-QC) model is proposed.The e-QC model is defined as a quality information service node with e-formalizing technology,whose input/output and intermediate process(that is IPO) are known to other nodes,and its implemention in MMPs is provided.In order to establish the e-QC model,a measuring network is constructed to acquire the original quality data,and the changes of process quality attributes are monitored and diagnosed by the integrated quality analysis tools attached to the e-QC,which can be tracked by information template network in real time.Furthermore,a hierarchical control method is adopted to coordinate e-QCs,in which the quality loss and adjusting cost are used to quantify the opportunities for e-QCs to improve process quality.At last,a prototype is developed to verify the proposed methods. | LIU DaoYu,JIANG PingYu & ZHANG YingFeng State Key Laboratory for Manufacturing Systems Engineering,Xi’an Jiaotong University,Xi’an 710049,China | 2008 | Science China(Technological Sciences)2008，51，12： | 3 |
| 3 | Diatom-inspired multiscale mineralization of patterned protein-polysaccharide complex structures显示文摘Marine diatoms construct their hierarchically ordered,three-dimensional(3D)external structures called frustules through precise biomineralization processes.Recapitulating the remarkable architectures and functions of diatom frustules in artificial materials is a major challenge that has important technological implications for hierarchically ordered composites.Here,we report the construction of highly ordered,mineralized composites based on fabrication of complex self-supporting porous structures—made of genetically engineered amyloid fusion proteins and the natural polysaccharide chitin—and performing in situ multiscale protein-mediated mineralization with diverse inorganic materials,including SiO_(2),TiO_(2)and Ga_(2)O_(3).Subsequently,using sugar cubes as templates,we demonstrate that 3D fabricated porous structures can become colonized by engineered bacteria and can be functionalized with highly photoreactive minerals,thereby enabling co-localization of the photocatalytic units with a bacteria-based hydrogenase reaction for a successful semi-solid artificial photosynthesis system for hydrogen evolution.Our study thus highlights the power of coupling genetically engineered proteins and polysaccharides with biofabrication techniques to generate hierarchically organized mineralized porous structures inspired by nature. | Ke Li Yingfeng Li Xinyu Wang Mengkui Cui Bolin An Jiahua Pu Jintao Liu Boyang Zhang Guijun Ma Chao Zhong | 2021 | National Science Review2021，8，8： | 1 |
| 4 | Effect of site-directed PEGylation of trichosanthin on its biological activity, immunogenicity, and pharmacokinetics显示文摘 | Qunxing An Yingfeng Lei Ning Jia Xianqing Zhang Yinlan Bai Jing Yi Rui Chen Aijun Xia Jing Yang Sanhua Wei Xiaodong Cheng Ailing Fan Shijie Mu Zhikai Xu | 2007 | Biomolecular Engineering2007，，6： | 1 |
| 5 | Mapping the antigenic determinants and reducing the immunogenicity of trichosanthin by site-directed mutagenesis显示文摘 | Qunxing An Sanhua Wei Shijie Mu Xianqing Zhang Yingfeng Lei Wei Zhang Ning Jia Xiaodong Cheng Ailing Fan Zhidong Li Zhikai Xu | 2006 | Journal of Biomedical Science2006，，5： | 1 |
| 6 | A rapid and efficient method for multiple-Site mutagenesis with a modified overlap extension PCR显示文摘 | An Yingfeng Ji Jianfei Wu Wenfang | 2005 | Appl Microbiol Biotechnol2005，68，3： | 1 |
| 7 | Miro2 supplies a platform for Parkin translocation to damaged mitochondria显示文摘PINK1/Parkin-mediated mitophagy is an important process in selective removal of damaged mitochondria, in which translocation of Parkin to damaged mitochondria is recognized as an initiation step. At present, how the damaged mitochondria are selectively recognized and targeted by Parkin is not fully understood. Here we show that Miro2, an outer mitochondrial membrane protein, undergoes demultimerization from a tetramer to a monomer and alteration in mitochondrial localization upon CCCP treatment, suggesting a CCCP-induced realignment of Miro2. The realignment of Miro2 is tightly regulated by PINK1-mediated phosphorylation at Ser325/Ser430 and by Ca^2+binding to EF2 domain, which are both essential for the subsequent Parkin translocation. Interestingly, ablation of Miro2 in mouse causes delayed reticulocyte maturation, lactic acidosis and cardiac disorders. Furthermore, several Miro2 mutations found in the congenital lactic acidosis patients also disable its realignment and Parkin translocation. These findings reveal an important role of Miro2 to mediate Parkin translocation by sensing both depolarization and Ca^2+release from damaged mitochondria to ensure the accuracy of mitophagy. | Jiu-Qiang Wang Shu Zhu Yihan Wang Fengli Wang Chaoqiang An Dongfang Jiang Lijie Gao Yingfeng Tu Xuefei Zhu Yun Wang Hongmei Liu Juanjuan Gong Zhongshuai Sun Xi Wang Leimei Liu Keyan Yang Caixia Guo Tie-Shan Tang | 2019 | Science Bulletin2019，64，11： | 0 |
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