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| 1 | Lean diabetes mellitus:An emerging entity in the era of obesity显示文摘Much has been published on the characteristics of type 2 diabetes mellitus and its association with the epidemic of obesity.But relatively little is known about the incidence of lean diabetes,progression of disease and fate of the patients with low-normal body mass index(< 25).Studies in developing countries have shown that the clinical characteristics of these patients include history of childhood malnutrition,poor socioeconomic status,relatively early age of onset and absence of ketosis on withdrawal of insulin.In the United States,recent studies showed that the lean,normal weight diabetes is not rare especially among minority populations.They showed that these patients are mainly males,have higher prevalence of insulin use indicating rapid beta cell failure.They might have increased total,cardiovascular and non cardiovascular mortality when compared to obese diabetic patients.In this review,the epidemiologic and clinical features of lean diabetes are presented.The potential causal mechanisms of this emerging diabetes type that may include genetic,autoimmune,acquired and behavioral factors are discussed.The need for studies to further elucidate the causation as well as specific prevention and treatment of lean diabetes is emphasized. | Amrutha Mary George Amith George Jacob Leon Fogelfeld | 2015 | World Journal of Diabetes2015，6，4： | 7 |
| 2 | Regulation of proline biosynthesis, degradation, uptake and transport in higher plants: its implications in plant growth and abiotic stress tolerance显示文摘 | Kishor P B K Sangam S Amrutha R N | 2005 | Current Science2005，88，3： | 1 |
| 3 | Regulation ofprolinebiosynthesis,degradation,up-take and transport inhigher plants:Its implications in plant growth and abioticstress tolerance显示文摘 | KISHOR P B K SANGAM S AMRUTHA R N | 2005 | Current science2005，88，： | 1 |
| 4 | Privacy Management of Multi User Environment in Online Social Networks (OSNs)显示文摘 | Amrutha P Sathiyaraj R | 2013 | GJCST-E: Network Web & Security2013，13，10： | 1 |
| 5 | Discovery of lesser known flavones as inhibitors of NF-kappa B signaling in MDA- MB-23t breast cancer cells-A SAR study显示文摘 | Amrutha K Nanjan P Shaji SK | 2014 | Bioorg Med Chem Lett2014，24，19： | 1 |
| 6 | Elicitor enhanced production of plumbagin in suspension cultures of Plumbago rosea L.显示文摘 | P Komaraiah R Naga Amrutha P.B Kavi Kishor S.V Ramakrishna | 2002 | Enzyme and Microbial Technology2002，，5： | 1 |
| 7 | Elicitor enhanced production of plumbagin in suspension cultures of plumbago rosea L显示文摘 | KOMARAIAH P AMRUTHA R N KAVI K P | 2002 | Enzym Microb Techn2002，31，5： | 1 |
| 8 | Regulation of proline biosynthesis, degradation, uptake and transport in higher plants: Its implications in plant growth and abiotic stress tolerance显示文摘 | Kavi Kishor P B Sangam S Amrutha R N | 2005 | Curr Sci2005，88，3： | 1 |
| 9 | Regulation of proline biosynthesis, degradation, up-take and transport in higher plants: its implications in plant growth and abiotic stress tolerance显示文摘 | Kishor P B K Sangam S Amrutha R N etal | 2005 | Current Science2005，88，： | 1 |
| 10 | Additive manufacturing of biodegradable porous orthopaedic screw显示文摘Advent of additive manufacturing in biomedical field has nurtured fabrication of complex,customizable and reproducible orthopaedic implants.Layer-by-layer deposition of biodegradable polymer employed in development of porous orthopaedic screws promises gradual dissolution and complete metabolic resorption thereby overcoming the limitations of conventional metallic screws.In the present study,screws with different pore sizes(916×918μm to 254×146μm)were 3D printed at 200μm layer height by varying printing parameters such as print speed,fill density and travel speed to augment the bone ingrowth.Micro-CT analysis and scanning electron micrographs of screws with 45%fill density confirmed porous interconnections(40.1%)and optimal pore size(259×207×200μm)without compromising the mechanical strength(24.58±1.36 MPa).Due to the open pore structure,the 3D printed screws showed increased weight gain due to the deposition of calcium when incubated in simulated body fluid.Osteoblast-like cells attached on screw and infiltrated into the pores over 14 days of in vitro culture.Further,the screws also supported greater human mesenchymal stem cell adhesion,proliferation and mineralized matrix synthesis over a period of 21 days in vitro culture as compared to non-porous screws.These porous screws showed significantly increased vascularization in a rat subcutaneous implantation as compared to control screws.Porous screws produced by additive manufacturing may promote better osteointegration due to enhanced mineralization and vascularization. | Ramya Dhandapani Priya Dharshini Krishnan Allen Zennifer Vishal Kannan Amrutha Manigandan Michael R.Arul Devina Jaiswal Anuradha Subramanian Sangamesh Gurappa Kumbar Swaminathan Sethuraman | 2020 | Bioactive Materials2020，5，3： | 1 |
| 11 | Regulation of proline biosynthesis,degradation,uptake and transport in higher plants:its implications in plant growth and abiotic stress tolerance显示文摘 | KISHOR P B K SANGAM S AMRUTHA R N | 2005 | Current Science2005，88，3： | 1 |
| 12 | Regula- tion of proline biosynthesis, degradation, uptake and trans- port in higher plants:Its implications in plant growth andabiotic stressto lerance 显示文摘 | Kavi Kishor P B Sangam S Amrutha R N | 2005 | Current Science2005，88，： | 1 |
| 13 | Regulation of praline biosynthesis, degradation, uptake and transport in higher plants: Its implications in plant growth and abiotie stress tolerance显示文摘 | Kishor P B K Sangam S Amrutha R N etal | 2005 | Current Science2005，88，3： | 1 |
| 14 | Regulation of proline biosynthesis, degradation, uptake and transport in higher plants: its implications in plant growth and abiotic stress tolerance显示文摘 | Kavikishore P B Sangam S Amrutha R N | 2005 | Curt Sci2005，88，： | 1 |
| 15 | Structural and optical characterization of oxygenated CdTe/ Sma+ in sol-gel silica glasses显示文摘 | Mathew S Rejikumar P R Amrutha K | 2009 | Materials Chemistry and Physics2009，355，： | 1 |
| 16 | Discovery of lesser known flavones as inhibitors of NF-KB signaling in MDA- MB-231 breast cancer cells a SAR study显示文摘 | Amrutha K Nanjan P Shaji SK | 2014 | Bioorg Med Chem Lett2014，24，19： | 1 |
| 17 | Regulation of proline biosynthesis,degradation,uptake and transport in higher plants:its implications in plant growth and abiotic stress tolerance显示文摘 | Kavi Kishor P B Sangam S Amrutha R N | 2005 | Curr Sci2005，88，： | 1 |
| 18 | Privacy Management of Multi User Environment in Online Social Networks (OSNs)显示文摘 | Amrutha P Sathiyaraj R | 2013 | GJCST-E: Network Web &Security2013，13，10： | 1 |
| 19 | Regulation of proline biosynthesis, degradation, uptake and transport in higher plants: its implications in plant growth and abiotic stress tolerance显示文摘 | KISHOR P B K SANGAM S AMRUTHA R N | 2005 | Current Science2005，88，3： | 1 |
| 20 | Regulation of proline biosynthesis?degradation,up-take and transport in higher plants:its implications in plant growth and abiotic stress tolerance显示文摘 | KISHOR P B K SANGAM S AMRUTHA R N | 2005 | Current Science2005，88，： | 1 |
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