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359篇 您的检索式:作者名="Ames BN"
    题名 作者 年代 出处 被引量
1对环境污染、农药与癌症预防的误解显示文摘引起癌症的主要原因有:吸烟、不平衡膳食、慢性传染病和激素因素。最近的研究表明:(1)啮齿类动物的致癌剂并不罕见。在标准的大剂量动物致癌试验中测试的化学物质,不论是天然的还是人工合成的,半数都是“致癌剂”;(2)啮齿类动物致癌试验中的致癌剂量很高,与低剂量的人类接触无关。动物试验所用剂量很高,正是使许多所试化学物质得出阳性结果的原因所在;(3)尽管在人类摄入的化学物质中有99.9%都是天然的,但是管理政策依然瞄准人工合成的化学物质。人类食用的植物中有数千种天然杀虫剂:在已测试的63种中有35种是啮齿类动物的致癌剂。还没有令人信服的证据证明合成的化学污染物在人类癌症形成中发挥了重要作用。要消除极低水平的合成化学物质需要投入巨额资金,据美国环保局估计进行这样的环境治理每年需耗资1400亿美元。癌症的预防要靠生物医学研究所获得的知识、公众的宣传教育和改变不良的生活方式。似乎有必要对目前的(包括公众和个人的)癌症预防重点进行重新审查。Ames BN Gold LS 1997国外医学(卫生学分册)1997,24,6:2
2Hair dyes are mutagenic identification of a variety of mutagenic components显示文摘Ames BN Kammen HO Edith Y 1975Proc Natl Sci USA1975,72,:2
3Antioxidatant activity of albumin-bound bilirubin显示文摘 Glazer AN Ames BN 1987Proc Natl Acad Sci USA1987,84,:1
4Use of intravenous lipids in neonates显示文摘Helbock HJ Ames BN 1995J Pecliatr1995,126,5:1
5Methods for detecting carcino gens and mutagens with the Salmonella/mammalian microsome mutagenicity test显示文摘Ames BN McCann J Yamasaki E 1975Murat Res1975,31,6:1
6Uric acid provides anantioxidant defense in humans against oxidant- and radi-cal-caused aging and cancer: a hypothesis显示文摘Ames BN Cathcart R Schwiers E 1981Proc Natl AcadSci U S A1981,78,11:1
7Oxidants, Antioxidants, and the Degenerative Diseases of Aging显示文摘AMES BN SHIGENAGA MK HAGEN TM 1993Proc Natl Acad Sci USA(S1091-6490)1993,90,:1
8Chemical carcinogenesis: too many rodent carcinogens 显示文摘Ames BN Gold LS 1990Proc Natl Acad Sci U S A1990,87,19:1
9Revised methods for the Salmonella mutagenicity test显示文摘 Ames BN 1983Mutant Res1983,113,:1
10Low intracellular Zinc induces oxidative DNA dam- age, disrupts P53, NFK B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line 显示文摘Ho E Ames BN 2002Cell Biology2002,99,16:1
11显示文摘Ames BN 1975Mut Res1975,31,:1
12Revised methods for the Salmomella mutagenicity test 显示文摘MARON DM AMES BN 1983Mutat Res1983,113,34:1
13Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component 显示文摘BROWN BN VALENTIN JE STEWART-AKERS AM 2009Biomaterials2009,30,8:1
14Delaying the mitochondrial decay of aging with acetylcarnitine显示文摘Ames BN Liu J 2004Ann N Y Acad Sci2004,1033,:1
15Life-supporting function of genetically modified swine lungs in baboons 显示文摘Nguyen BN Azimzadeh AM Zhang T 2007J Thorac Cardiovasc Surg2007,133,5:1
16Quantitation of age -related mitochon drial DNA deletions in rat tissues shows that their pattern of accumulation differs from that of humans 显示文摘 Ames BN 1998Gene1998,209,:1
17The free radical theory of aging matures显示文摘Beckman KB Ames BN 1998Physiol Rev1998,78,2:1
18Fe^ 2+ induces a transient Ca^2+ release from rat liver mitoehondria显示文摘Gogvadze V Walter PB Ames BN 2002Arch Biochem Biophys2002,398,2:1
19Ubiquinol-10 is an effective lipid-soluhle antioxidant at physiological concentrations显示文摘Frei B Kim MC Ames BN 1990Proc Natl Acad Sci USA1990,87,12:1
20High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased):relevance to genetic disease and polymorphisras显示文摘Ames BN Elson-Schwab I Sliver EA 2002Am J Clin Nutr2002,75,4:1
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