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| 1 | Viral and host causes of fatty liver in chronic hepatitis B显示文摘AIM: To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage.METHODS: A total of 164 patients (113 males and 51 females, average age 35±11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with <5% hepatosteatosis) and group with steatosis (64 patients with >5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with >25% steatosis). RESULTS: In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and triglyceride levels were significantly higher than those in the group without steatosis (P<0.05). Steatosis was found in 53 (46.9%) of male patients and 11 (22%) of female patients (P<0.05). No significant difference was found in the positivity of ALT, AST, ALP, GGT, HBeAg, viral load, histological activity index (HAI) and stage between the two groups (P>0.05). In the group with severe steatosis, the BMI was significantly higher than that in the group with mild steatosis (P<0.05). No significant difference was found in the other parameters between the groups (P>0.05). CONCLUSION: Steatosis in chronic hepatitis B appears to be a result of metabolic factors of the host rather than the effect of viruses. Steatosis is unrelated to the HAI and degree of fibrosis, which are considered as the histological indicators of liver damage. | Emin Altiparmak Seyfettin K(o|¨)klü Mesut Yalinkilic Osman Yüksel Bahattin Cicek Ertugrul Kayacetin Tülin Sahin | 2005 | World Journal of Gastroenterology2005，11，20： | 52 |
| 2 | Increased levels of homocysteine in patients with ulcerative colitis显示文摘AIM: To investigate serum levels of homocysteine (Hcys) and the risk that altered levels carry for thrombosis development in ulcerative colitis (UC) patients. METHODS: 55 UC patients and 45 healthy adults were included. Hcys, vitamin B12 and folic acid levels were measured in both groups. Clinical history and thrombo- embolic events were investigated. RESULTS: The average Hcys level in the UC patients was 13.3 ± 1.93 μmmol/L (range 4.60-87) and was higher than the average Hcys level of the control group which was 11.2 ± 3.58 μmmol/L (range 4.00-20.8) (P < 0.001). Vitamin B12 and folic acid average values were also lower in the UC group (P < 0.001). Whenmultivariate regression analysis was performed, it was seen that folic acid deficiency was the only risk factor for hyperhomocysteinemia. Frequencies of thromboembolic complications were not statistically significantly different in UC and control groups. When those with and without a thrombosis history in the UC group were compared according to Hcys levels, it was seen that there were no statistically significant differences. A negative linear relationship was found between folic acid levels and Hcys. CONCLUSION: We could not find any correlations between Hcys levels and history of prior thromboembolic events. | Sabiye Akbulut Emin Altiparmak Firdevs Topal Ersan Ozaslan Metin Kucukazman Ozlem Yonem | 2010 | World Journal of Gastroenterology2010，16，19： | 13 |
| 3 | A genetic algorithm for two-stage transportation problem using priority-based encoding 显示文摘 | GEN M ALTIPARMAK F LIN L | 2006 | OR Spectrum2006，28，3： | 1 |
| 4 | Localsearch genetic algorithm for optimal design of reliable net2works显示文摘 | Berna Denig Fulya Altiparmak Alice E Smith | 1997 | Transaction on Evolution Computation1997，，9： | 1 |
| 5 | A genetic algorithm for two-stage transportation problem using priority-based encoding 显示文摘 | ALTIPARMAK F LIN L GEN M | 2006 | OR Spectram2006，28，3： | 1 |
| 6 | Treatment of renal transplant recipients with low bone mineral density:a randomized prospective trial of alendronate, alfacalcidol,and alendronate combined with alfacalcidol 显示文摘 | TrabuIus S Altiparmak MR Apaydin S | 2008 | Transplant Proc2008，40，： | 1 |
| 7 | Effect of interferon and ribavirin combined with amantadine in interferon and ribavirin non-responder patients with chronic hepatitis C (genotype 1)显示文摘AIM: To evaluate the efficacy of amantadine plus interferonalpha and ribavirin in non-responder patients with chronic hepatitis C.METHODS: Twenty-six non-responder patients received the regimen of IFN-α-2a at a dose of 6 million units three times a week, 1 000-1 200 mg of ribavirin daily, and 200 mg of amantadine daily in divided doses over 48 wk. After the end of treatment, at the 72nd wk, a sustained viral response rate was determined.RESULTS: An early (after 12 wk of therapy) response was seen in 34.6% (9/26) of patients. Response rate at the 24th wk was 42.3% (11/26). End of treatment response (ETR) was 53.8% (14/26). Sustained viral response (SVR) was 42.3% (11/26). There was a statistically significant difference between 0 and 12 wk (P = 0.04), 0 and 24 wk (P = 0.01), 0 and 48 wk (P = 0.00), and 0 and 72 wk (P = 0.001). No patient had severe adverse effects during the treatment.CONCLUSION: Combination regimen of interferon-α,ribavirin and amantadine can enhance sustained viral response on IFN-α and ribavirin non-responder patients with HCV. Triple therapy with amantadine should be evaluated in further studies. | Dilek Oguz Bahattin Cicek Levent Filik Bulent Odemis Mesut Kilic Engin Altintas Neslihan Zengin Emin Altiparmak | 2005 | World Journal of Gastroenterology2005，11，4： | 1 |
| 8 | Improvement of Diesel Fuel Properties by Using Additives 显示文摘 | Gfiru M Karakaya U Altiparmak D | 2002 | Energy Conversion and Management2002，43，8： | 1 |
| 9 | Multi-objective optimization of a stochastic assembly line balancing: a hybrid simulated annealing algorithm 显示文摘 | Cakir B Altiparmak F Dengiz B | 2011 | Computers & Industrial Engineering2011，60，3： | 1 |
| 10 | Obligatory referral among other factors associated with peritonitis in peritoneal dialysis patients显示文摘 | Oygar DD Yalin AS Altiparmak MR | 2011 | Nefrologia2011，31，4： | 1 |
| 11 | Mycobacterium tuberculosis infections after renal transplantation显示文摘 | Apaydin S Altiparmak MR Serdengecti K | 2000 | Scand J Infect Dis2000，32，5： | 1 |
| 12 | A hy- brid discrete particle swarm optimization for vehicle routing problem with simultaneous pickup and delivery显示文摘 | GOKSAL F P KARAOGLAN I ALTIPARMAK F | 2013 | Computers Industrial Engineering2013，65，1： | 1 |
| 13 | A bra- nch and cut algorithm for the location-routing problem with simultaneous pickup and delivery显示文摘 | KARAOGLAN I ALTIPARMAK F KARA I | 2011 | European Journal of Op- erational Research2011，211，2： | 1 |
| 14 | Usefulness of the epicardial fat tissue thickness as a diagnostic criterion for geriatric patients with metabolic syndrome显示文摘ObjectiveTo 与新陈代谢的症候群(MetS ) 为衰老老人病人作为一个诊断标准评估 epicardial 脂肪织物厚度(EFTT ) 超过 65 岁的 .MethodsSixty 衰老老人病人为学习被招募。病人们被划分成二个组:组 1 (n = 30 ) 与 MetS 由病人组成了;组 2 (n = 30 ) 没有 MetS,由病人组成了。Echocardiography 被用来在所有病人测量 EFTT,并且血样品被分析让生物化学的 parameters.ResultsCompared 组织 2,组 1 的 EFTT 层次统计上更高(P <0.05 ) 。在二进制逻辑回归分析, EFTT 层次为新陈代谢的症候群用作独立因素(B = 17.35, SE = 4.93, Wald = 12.36, P <0.001 ) 。操作典型曲线(巨鸟曲线) 分析的接收装置表明 EFTT 在 7.3 公里的水平上面与 96.7% 敏感和 86.7% 特性预言了 MetS [在曲线 = 下面的区域 0.969;95% 信心间隔(CI ) :0.928-1.00 ] 学习表明了的在场的 .ConclusionsThe 浆液 EFTT 铺平,这在有 MetS 的衰老老人病人是更高的并且能因此为 MetS 被用作一个诊断标准。 | Bema Kaya Bedri Caner Kaya Emel Yigit Karakas Sadettin Selcuk Baysal Dursun Cadirci Emre Erkus Ibrahim Halil Altiparmak Emin Savik Hatice Sezen Tttrgay Ulas | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
| 15 | The location routing problem with simultaneous pickup and deliv- ery: Formulations and a heuristic approach显示文摘 | KARAOGLAN I ALTIPARMAK F KARA I | 2012 | Omega2012，40，4： | 1 |
| 16 | A genetic algorithm approach for multi-objective optimization of supply chain networks显示文摘 | Altiparmak F Gen M Lin L etal | 2006 | Computer Indusrial Engineering2006，51，1： | 1 |
| 17 | Prevalence of serum antibodies to hepatitis B and C viruses in patients with primary glomerulonephritis显示文摘 | Altiparmak MR Pamuk ON Pamuk GE | 2001 | J Nephrol2001，14，5： | 1 |
| 18 | A hybrid discrete particle swarm optimization for vehicle routing problem with simultaneous pickup and delivery显示文摘 | GOKSAL F P KARAOGLAN I ALTIPARMAK F | | 0，，： | 1 |
| 19 | Opportunistic pulmonary infection after renal transplantation显示文摘 | Kalender B Apaydin S Altiparmak MR | 2000 | Transplant Proc2000，32，7： | 1 |
| 20 | Alternative fuel properties of tall oil fatty acid methylester-diesel fuel blends 显示文摘 | Altiparmak D Keskin A Koca A | 2007 | Bioresource Technology2007，98，2： | 1 |
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