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| 1 | Effects of the growth regulator 4-PU-30 on growth,K+ content,and alkaloid production in tobacco callus cultures显示文摘 | Priol T Palazon J Altabella T | 1987 | J Plant Growth Regul1987，5，4： | 1 |
| 2 | Polyamines: molecules with regulatory functions in plant abiotic stress tolerance显示文摘 | AlcgLzar R R Altabella T Marco F | 2010 | Planta2010，231，6： | 1 |
| 3 | Polyamines:Molecules with regulatory functions in plant abiotic stress tolerance显示文摘 | Alcázar R Altabella T Marco F | 2010 | Planta2010，231，6： | 1 |
| 4 | Recent advances inpolyamine research显示文摘 | KUMAR A ALTABELLA T TAYLOR M A | 1997 | Trends in Plant Science1997，2，： | 1 |
| 5 | Arginine decarboxylase is localized in chloroplasts显示文摘 | Borrell A Culianez-Macia F A Altabella T | 1995 | Plant Physiol1995，109，： | 1 |
| 6 | New insights into the role of spermine in Arabidopsis thaliana under long-term salt stress显示文摘 | Analía I. Alet Diego H. Sánchez Juan C. Cuevas María Marina Pedro Carrasco Teresa Altabella Antonio F. Tiburcio Oscar A. Ruiz | 2011 | Plant Science2011，，： | 1 |
| 7 | Polyamines in plants : An overview 显示文摘 | KAUR- SAWHNEY R TIBURCIO A F ALTABELLA T | 2003 | J Cell Mol Biol2003，，2： | 1 |
| 8 | Recent advances in polyamine research显示文摘 | Kumar A Altabella T Taylor M A | 1997 | Trends in Plant Science1997，2，4： | 1 |
| 9 | Inducible overexpression of oat arginine decarboxylase in transgenic tobacco plants显示文摘 | Masgrau C Altabella T Farras R | 1997 | The Plant Journal1997，11，3： | 1 |
| 10 | Polyamines: molecules with regulatory functions in plant abiotic stress tolerance显示文摘 | Rubén Alcázar Teresa Altabella Francisco Marco Cristina Bortolotti Matthieu Reymond Csaba Koncz Pedro Carrasco Antonio F. Tiburcio | 2010 | Planta2010，，6： | 1 |
| 11 | Involvement of polyamines in plant response to abiotic stress显示文摘 | Rubén Alcázar Francisco Marco Juan C. Cuevas Macarena Patron Alejandro Ferrando Pedro Carrasco Antonio F. Tiburcio Teresa Altabella | 2006 | Biotechnology Letters2006，，23： | 1 |
| 12 | Effects of putrescine accumulation in tobacco transgenic plants with different expression levels of oat arginine decarboxylase显示文摘 | PANICOT M MASGRAU C BORRELL A CORDEIRO A TIBURCIO A F ALTABELLA T | 2002 | Physiologia Plantarum2002，114，： | 1 |
| 13 | Regulation ofarginine decarboxylase by spermine in osmotically-stressed oatleaves 显示文摘 | Borrell A Besford RT Altabella T | 1996 | Physiol Plant1996，98，： | 1 |
| 14 | Tobacco plants transformed with the bean a? gene express an inhibitor of insect, a-amylase in their seeds显示文摘 | | 1990 | Plant Physiol1990，93，： | 1 |
| 15 | Slow-growth phenotype of transgenie tomato expressing apoplastic invertase显示文摘 | Dickinson CD Altabella T Chrispeels MJ | 1991 | Plant Physiology1991，95，2： | 1 |
| 16 | Slow growth phenotype of transgenic tomato expressing apoplastic invertase显示文摘 | DICHINSON C D ALTABELLA T CHRISPEELS M J | 1991 | Plant Physiol1991，95，： | 1 |
| 17 | Plant polyamines in reproductive activities and response to abiotic stress显示文摘 | GALSTON A W KAUR-SAWHNEY R ALTABELLA T | 1997 | Bot Acta1997，110，： | 1 |
| 18 | Polyamine metabolism and its regulation 显示文摘 | Tiburcio A F Altabella T Borrell A | 1997 | Physiol Plant1997，100，3： | 1 |
| 19 | Tobacco plants transformed with the bean an gene express an inhibitor of inseect amylase in their seeds显示文摘 | Chrispeels M | 1990 | Plant Physio1990，93，： | 1 |
| 20 | Computed tomography-based radiomic to predict resectability in locally advanced pancreatic cancer treated with chemotherapy and radiotherapy显示文摘BACKGROUND Surgical resection after neoadjuvant treatment is the main driver for improved survival in locally advanced pancreatic cancer(LAPC).However,the diagnostic performance of computed tomography(CT)imaging to evaluate the residual tumour burden at restaging after neoadjuvant therapy is low due to the difficulty in distinguishing neoplastic tissue from fibrous scar or inflammation.In this context,radiomics has gained popularity over conventional imaging as a complementary clinical tool capable of providing additional,unprecedented information regarding the intratumor heterogeneity and the residual neoplastic tissue,potentially serving in the therapeutic decision-making process.AIM To assess the capability of radiomic features to predict surgical resection in LAPC treated with neoadjuvant chemotherapy and radiotherapy.METHODS Patients with LAPC treated with intensive chemotherapy followed by ablative radiation therapy were retrospectively reviewed.One thousand six hundred and fifty-five radiomic features were extracted from planning CT inside the gross tumour volume.Both extracted features and clinical data contribute to create and validate the predictive model of resectability status.Patients were repeatedly divided into training and validation sets.The discriminating performance of each model,obtained applying a LASSO regression analysis,was assessed with the area under the receiver operating characteristic curve(AUC).The validated model was applied to the entire dataset to obtain the most significant features.RESULTS Seventy-one patients were included in the analysis.Median age was 65 years and 57.8%of patients were male.All patients underwent induction chemotherapy followed by ablative radiotherapy,and 19(26.8%)ultimately received surgical resection.After the first step of variable selections,a predictive model of resectability was developed with a median AUC for training and validation sets of 0.862(95%CI:0.792-0.921)and 0.853(95%CI:0.706-0.960),respectively.The validated model was applied to the entire dataset and 4 features were selected to build the model with predictive performance as measured using AUC of 0.944(95%CI:0.892-0.996).CONCLUSION The present radiomic model could help predict resectability in LAPC after neoadjuvant chemotherapy and radiotherapy,potentially integrating clinical and morphological parameters in predicting surgical resection. | Gabriella Rossi Luisa Altabella Nicola Simoni Giulio Benetti Roberto Rossi Martina Venezia Salvatore Paiella Giuseppe Malleo Roberto Salvia Stefania Guariglia Claudio Bassi Carlo Cavedon Renzo Mazzarotto | 2022 | World Journal of Gastrointestinal Oncology2022，14，3： | 1 |
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