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| 1 | Improved guided bone regeneration by combined application of unmodified, fresh autologous adipose derived regenerative cells and plasma rich in growth factors:A first-in-human case report and literature review显示文摘BACKGROUND Novel strategies are needed for improving guided bone regeneration(GBR) in oral surgery prior to implant placement, particularly in maxillary sinus augmentation(GBR-MSA) and in lateral alveolar ridge augmentation(LRA). This study tested the hypothesis that the combination of freshly isolated, unmodified autologous adipose-derived regenerative cells(UA-ADRCs), fraction 2 of plasma rich in growth factors(PRGF-2) and an osteoinductive scaffold(OIS)(UAADRC/PRGF-2/OIS) is superior to the combination of PRGF-2 and the same OIS alone(PRGF-2/OIS) in GBR-MSA/LRA.CASE SUMMARY A 79-year-old patient was treated with a bilateral external sinus lift procedure as well as a bilateral lateral alveolar ridge augmentation. GBR-MSA/LRA was performed with UA-ADRC/PRGF-2/OIS on the right side, and with PRGF-2/OIS on the left side. Biopsies were collected at 6 wk and 34 wk after GBRMSA/LRA. At the latter time point implants were placed. Radiographs(32 mo follow-up time) demonstrated excellent bone healing. No radiological or histological signs of inflammation were observed. Detailed histologic,histomorphometric, and immunohistochemical analysis of the biopsies evidenced that UA-ADRC/PRGF-2/OIS resulted in better and faster bone regeneration than PRGF-2/OIS.CONCLUSION GBR-MSA with UA-ADRCs, PRGF-2, and an OIS shows effectiveness without adverse effects. | ?nder Solakoglu Werner G?tz Maren C Kiessling Christopher Alt Christoph Schmitz Eckhard U Alt | 2019 | World Journal of Stem Cells2019，11，2： | 3 |
| 2 | Formation of disulfide bonds in acid-induced gels of preheated whey protein isolate显示文摘 | ALTING A C HAMER R J DE C G | 2000 | J Agric Food Chem2000，48，10： | 1 |
| 3 | The arteries of the humeral head and their relevance in fracture treatment 显示文摘 | Meyer C Alt V Hassanin H | 2005 | Surg Radiol Anat2005，27，3： | 1 |
| 4 | Platinum and rhodium concentrations in airborne particulate matter in Germany from 1988 to 1998显示文摘 | Zereini F Wiseman C Alt F | 2001 | Environmental Science Technology2001，35，： | 1 |
| 5 | Independent validation of the 2010 American Joint Committee on Cancer TNM classification for renal cell carcinoma: results from a large, single institution co- hort 显示文摘 | Kim SP Alt AL Weight C J | 2011 | J Urol2011，185，： | 1 |
| 6 | Texture of acid milk gels: formation of disulfide cross-links during acidification显示文摘 | VASBINDER A J ALTING A C VISSCHERS R W | 2003 | International Dairy Journal2003，13，： | 1 |
| 7 | Hydrothermal sulfide and oxide deposits on seamounts near 21°N, East Pacific Rise显示文摘 | Alt J C Lonsdale P Haymon R | 1987 | Geological Society of America Bulletin1987，98，： | 1 |
| 8 | Inhibition of neointima formation after experimental coronary artery stenting:a new biodegradable stent coating releasing hirudin and the prostacyclin analogue iloprost显示文摘 | Alt E Haehnel I Beilharz C | 2000 | Circulation2000，101，12： | 1 |
| 9 | Physical and chemical interactions in cold gelation of food proteins显示文摘 | ALTING A C DE JONGH H H J VISSCHERS R W | 2002 | J Agric Food Chem2002，50，16： | 1 |
| 10 | Number of thiol groups rather than the size of the aggregates determines the hardness of cold set whey protein gels显示文摘 | ALTING A C HAMER R J DEKRUIF C G | 2003 | Food Hydrocolloids2003，17，4： | 1 |
| 11 | Purification and characterization of cystathionine β-lyase fi:om Lactococcus lactis subsp, cremoris B78 and its possible role in flavor development in cheese显示文摘 | ALTING A C ENGELS W van SCHALKWIJK | 1995 | Applied and Environmental Microbiology1995，61，11： | 1 |
| 12 | Palonosetron triggers 5 - HT(3) receptor internalization and causes prolonged inhibition of receptor function 显示文摘 | ROJAS C THOMAS A G ALT J | 2010 | Eur J Pharmacol2010，626，3： | 1 |
| 13 | Oxygen isotope ratios of PO43-:an inorganic indicator of enzymatic activity and P metabolism and a new biomarker in the search for life显示文摘 | Blake R E Alt J C Martini A M | 2001 | Proceeding of the National Academy of Sciences of the United States of America2001，98，5： | 1 |
| 14 | NO reduction by hydrocarbons in an oxidizing atmosphere over transition metal-zirconium mixed oxides显示文摘 | Bethke K A Alt D Kung M C | 1994 | Catalysis Letter1994，25，： | 1 |
| 15 | Sartans,angiotensin Ⅱ receptor antagonists,can induce psoriasis显示文摘 | Marquart-Elbaz C Grosshans E Alt M | 2002 | British Journal of Dermatology2002，147，3： | 1 |
| 16 | Formation of disulfide bonds in acid-induced gels of preheated whey protein isolate 显示文摘 | Alting A C Hamer R J de Kruif C G | 2000 | Journal of Agricultural and Food Chemistry2000，48，10： | 1 |
| 17 | Evaluation of consultation in community pharmacies with mystery shoppers 显示文摘 | ALTE D WEITSCHIES W RITTER C A | 2007 | Ann Pharmacother2007，41，6： | 1 |
| 18 | Formation of disul?debondsin acid-induced gels of preheated whey protein isolate显示文摘 | Alting A C Hamer R J Kruif C G | | 0，，48： | 1 |
| 19 | Gene and protein expression profiling of the microvascular compartmenl in experimental autoimmune encephalomyelitis in C57B1/6 and SJL mice显示文摘 | Alt C Duvefelt K Franzen B | 2005 | Brain Pathol2005，15，： | 1 |
| 20 | Aging alters tissue resident mesenchymal stem cell properties显示文摘 | Alt EU Senst C Murthy SN | 2012 | Stem Cell Res2012，8，2： | 1 |
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