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| 1 | Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome显示文摘We report a case of virus-induced acute respiratory distress syndrome(ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection. From very significant preclinical research performed at Virginia Commonwealth Universitywith vitamin C and with the very positive results of a previously performed phase Ⅰ safety trial infusing high dose vitamin C intravenously into patients with severe sepsis, we reasoned that infusing identical dosing to a patient with ARDS from viral infection would be therapeutic. We report here the case of a 20-year-old, previously healthy, female who contracted respiratory enterovirus/rhinovirus infection that led to acute lung injury and rapidly to ARDS. She contracted the infection in central Italy while on an 8-d spring break from college. During a return flight to the United States, she developed increasing dyspnea and hypoxemia that rapidly developed into acute lung injury that led to ARDS. When support with mechanical ventilation failed, extracorporeal membrane oxygenation(ECMO) was initiated. Twelve hours following ECMO initiation, high dose intravenous vitamin C was begun. The patient's recovery was rapid. ECMO and mechanical ventilation were discontinued by day-7 and the patient recovered with no long-term ARDS sequelae. Infusing high dose intravenous vitamin C into this patient with virus-induced ARDS was associated with rapid resolution of lung injury with no evidence of post-ARDS fibroproliferative sequelae. Intravenous vitamin C as a treatment for ARDS may open a new era of therapy for ARDS from many causes. | Alpha A Fowler Ⅲ Christin Kim Lawrence Lepler Rajiv Malhotra Orlando Debesa Ramesh Natarajan Bernard J Fisher Aamer Syed Christine DeWilde Anna Priday Vigneshwar Kasirajan | 2017 | World Journal of Critical Care Medicine2017，6，1： | 9 |
| 2 | 小波多尺度方法用于边缘检测显示文摘小波极大值表达式给出了重构图像信息的一种新方法 ,它能从图像边缘的属性上扩展解决图像处理问题的方法 .由此提出小波多尺度方法对边缘进行检测和重构 .实验结果表明图像近似值可以从小波模极大值点中重构 。 | Keita Alpha 彭嘉雄 | 2001 | 华中科技大学学报(自然科学版)2001，29，5： | 5 |
| 3 | High Risk Factors of Pancreatic Carcinoma显示文摘Over the past decades, cancer has become one of the toughest challenges for health professionals. The epidemiologists are increasingly directing their research efforts on various malignant tumor worldwide. Of note, incidence of cancers is on the rise more quickly in developed countries. Indeed, great endeavors have to be made in the control of the life-threatening disease. As we know it, pancreatic cancer(PC) is a malignant disease with the worst prognosis. While little is known about the etiology of the PC and measures to prevent the condition, so far, a number of risk factors have been identified. Genetic factors, pre-malignant lesions, predisposing diseases and exogenous factors have been found to be linked to PC. Genetic susceptibility was observed in 10% of PC cases, including inherited PC syndromes and familial PC. However, in the remaining 90%, their PC might be caused by genetic factors in combination with environmental factors. Nonetheless, the exact mechanism of the two kinds of factors, endogenous and exogenous, working together to cause PC remains poorly understood. The fact that most pancreatic neoplasms are diagnosed at an incurable stage of the disease highlights the need to identify risk factors and to understand their contribution to carcinogenesis. This article reviews the high risk factors contributing to the development of PC, to provide information for clinicians and epidemiologists. | Soriba Naby Camara 殷涛 杨明 李响 龚琼 周静 赵刚 杨智勇 Tajoo Aroun Martin Kuete Sonam Ramdany Alpha Kabinet Camara Aissatou Taran Diallo 冯珍 宁辛 熊炯新 陶京 钦琪 周伟 崔静 黄敏 郭尧 勾善淼 王博 刘涛 Ohoya Etsaka Terence Olivier Tenin Conde Mohamed Cisse Aboubacar Sidiki Magassouba Sneha Ballah Naby Laye Moussa Keita Ibrahima Sory Souare Aboubacar Toure Sadamoudou Traore Abdoulaye Korse Balde Namory Keita Naby Daouda Camara Dusabe Emmanuel 吴河水 王春友 | 2016 | Journal of Huazhong University of Science and Technology(Medical Sciences)2016，36，3： | 3 |
| 4 | Making and breaking contacts: the cellular biology of cadherin regulation显示文摘 | Alpha S Yap Matthew S Crampton Jeff Hardin | 2007 | Current Opinion in Cell Biology2007，，5： | 2 |
| 5 | The effect of vitamin E and betacarotene on the incidence of lung cancer and other cancers in male smokers显示文摘 | The Alpha -Tocopherol Beta-carotene Cancer Prevention Study Group | 1994 | N Engl J Med1994，330，： | 2 |
| 6 | Effect on hepatitis B virus DNA levds in children infected with different genotypes显示文摘 | Sangfelt P Norder H Magnius LO Interferon - alpha 2b treament in hepatitis B carriers | 1997 | Acta Paediatr1997，86，2： | 1 |
| 7 | 显示文摘 | Lafuente MP Villegas-Perez MP Sobrado-Calvo P : Neuroprotective effects of alpha (2)-selective adrenergic agonists against ischemiainduced retinal ganglion cell death | 2001 | Invest Ophthalmol Vis Sci2001，42，： | 1 |
| 8 | Omega-dicarboxylic Acid Salts and Alpha, Omega-dicarboxy lie Acids-photooxidation Products of Unsaturated Fatty-acids, Present in Marine Aerosols and Marine Sediments显示文摘 | Stephanou EG Alpha | 1992 | Naturwissenschaften1992，79，： | 1 |
| 9 | Growth and Photo- synthetic Responses of Scaevola sericea, A Hawaiian Coast- al Shrub, to Substrate Salinity and Salt Spray 显示文摘 | Goldstein G Drake D R Alpha C | 1996 | Interna- tional Journal of Plant Sciences1996，157，2： | 1 |
| 10 | The Istanbul consensus work-shop on embryo assesvsment: proceedings of an expert meeting显示文摘 | Alpha Scientists in Reproductive Medicine and ESHRE SpecialInterest Group of Embryology | 2011 | Human Reproduction2011，26，6： | 1 |
| 11 | The Istanbul consen- sus workshop on embryo assessment: proceedings of an expert meeting 显示文摘 | Alpha Scientists in Reproductive Medicine and ESHRE Spe- cial Interest Group of Embryology | 2011 | Hum Reprod2011，26，6： | 1 |
| 12 | , a long - term study显示文摘 | Dammacco F Tucci FA Lauletta G et aL Pegylated inter- feron- alpha ribavirin and rituximab combined therapy of hepatitis Cvirus - related mixed cryoglobulinemia | 2010 | Blood2010，116，3： | 1 |
| 13 | , synergistic increase of CYP3A 4 induction by pregnane X receptor activators显示文摘 | PASCUSSI J M DROCOURT L FABRE J M Dexamethasone induces pregnane X receptor and retinoid X receptor alpha expression in human hepatocytes | 2000 | Mol Pharmacol2000，58，2： | 1 |
| 14 | 38N Super Duples Stainless Steel显示文摘 | Nilsson J O Kangas P Karlsson T Mechanical Properties Mi- crostructural Stability and Kinetics of (Alpha)-phase Formation in 29Cr-6Ni-2Mo43 | 2000 | Metallurgical and Materials Transaction2000，31，1： | 1 |
| 15 | A detecting method for peripheral venous AFP mRNA in hepatocellular carcinoma显示文摘AdetectingmethodforperipheralvenousAFPmRNAinhepatocelularcarcinomaHUChengJinandYANGDaoLiSubjectheadingsliverneoplasms;carci... | HU Cheng Jin and YANG Dao Li Keywords liver neoplasms carcinoma,hepatocellular alpha fetoproteins mRNA polymerase chain reaction | 1997 | World Journal of Gastroenterology1997，3，3： | 1 |
| 16 | The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting 显示文摘 | Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology | 2011 | Hum Reprod2011，26，6： | 1 |
| 17 | Effectiveness of barriers to minimize VOC emissions including formaldehyde显示文摘 | Barry Alpha Corneau Diane | 2006 | Forest Products Journal2006，56，9： | 1 |
| 18 | Challenges of the maize seed industry in eastern and southern Africa: A compelling case for private–public intervention to promote growth显示文摘 | Augustine S. Langyintuo Wilfred Mwangi Alpha O. Diallo John MacRobert John Dixon Marianne B?nziger | 2010 | Food Policy2010，，4： | 1 |
| 19 | Estrogen mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarction显示文摘 | Hamada H Kim MK receptors alpha and beta Iwakura A | 2006 | Circulation2006，114，21： | 1 |
| 20 | The Istanbul consensus workshop on embryo assessment:proceedings of an expert meeting显示文摘 | Alpha Scientists in Reproductive Medicine and ESHRE Spe- cial Interest Group of Embryology | 2011 | Hum Reprod2011，26，6： | 1 |
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