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| 1 | Circulating tumor cells(CTCs)in breast cancer:a diagnostic tool for prognosis and molecular analysis显示文摘Metastatic breast cancer(MBC)is characterized by a combination of tumor growth,proliferation and metastatic progression and is typically managed with palliative intent.The benefit of standard systemic therapies is relatively limited and the disease is considered incurable suggesting the need to investigate the biological drivers of the various phases of the metastatic process in order to improve the selection of molecularly driven therapies.The detection,enumeration and molecular analysis of circulating tumor cells(CTCs)provide an intriguing opportunity to advance this knowledge.CTCs enumerated by the Food and Drugs Administration-cleared CellSearch TM system are an independent prognostic factor of progressionfree survival(PFS)and overall survival(OS)in MBC patients.Several published papers demonstrated the poor prognosis for MBC patients that presented basal CTC count ≥5 in 7.5mL of blood.Therefore,the enumeration of CTCs during treatment for MBC provides a tool with the ability to predict progression of disease earlier than standard timing of anatomical assessment using conventional radiological tests.During the metastatic process cancer cells exhibit morphological and phenotypic plasticity undergoing epithelialmesenchymal transition(EMT).This important phenomenon is associated with down regulation of epithelial marker(e.g.,EpCAM)with potential limitations in the applicability of current CTCs enrichment methods.Such observations translated in a number of investigations aimed at improving our capabilities to enumerate and perform molecular characterization of CTCs.Theoretically,the phenotypic analysis of CTCs can represent a 'liquid' biopsy of breast tumor that is able to identify a new potential target against the metastatic disease and advance the development and monitoring of personalized therapies. | Xiaoshen Dong R.Katherine Alpaugh Massimo Cristofanilli | 2012 | Chinese Journal of Cancer Research2012，24，4： | 5 |
| 2 | Isolation and characterization of circulating tumor cells in patients with metastatic colorectal cancer显示文摘 | Cohen S J Alpaugh R K Gross S | 2006 | Clin Coloreetal Cancer2006，6，2： | 1 |
| 3 | Fibroblast activation protein and its relationship to clinical outcome in pancreatic adenocarcinoma显示文摘 | Cohen SJ Alpaugh RK Palazzo I | 2008 | Pancreas2008，37，2： | 1 |
| 4 | Circulating tumor cells: evolving evidence and future ehallenges显示文摘 | Dotan E Cohen SJ Alpaugh KR | 2009 | Oncologist2009，14，11： | 1 |
| 5 | Fibroblast activation protein and its relationship to clinical outcome in pancreatic Aden carcinoma 显示文摘 | Cohen S J Alpaugh RK Palazzo I | 2008 | Pancreas2008，37，2： | 1 |
| 6 | Relationship of sialylLewis(x/a) underexpression and E- cadherin overexpression in the lymphovascular embolus of inflammatory breast carcinoma显示文摘 | Alpaugh ML Tomlinson JS YE Y | 2002 | Ame J pathol2002，161，2： | 1 |
| 7 | Are There Sex Differences in Creativity Across the Adult Life Span?显示文摘 | Alpaugh P K Birren J E | 1975 | Human Development1975，18，6： | 1 |
| 8 | Superantigen-based immunotherapy: a phase I trial ofPNU-214565, a monoclonal antibody-staphylococcal enterotoxin A recombinant fusion protein, in advanced pancreatic and colorectal cancer显示文摘 | Giantonio BJ Alpaugh RK Schultz J | 1997 | J Clin Oncol1997，15，5： | 1 |
| 9 | Fibroblast activation protein and its relationship to clinical outcome in pancreatic adenocarcinoma显示文摘 | Cohen SJ Alpaugh RK Palazzo I | 2008 | Pancreas2008，37，2： | 1 |
| 10 | Fibroblast activation protein and its relationship to clinical outcome in pancreatic adenocarcinoma 显示文摘 | Cohen SJ Alpaugh RK Palazzo I | 2008 | Pancreas2008，37，2： | 1 |
| 11 | An intact overexpressed E-cadherin/alpha,beta-catenin axis characterizes the lymphovascular emboli of inflammatory breast carcinoma显示文摘 | Tomlinson JS Alpaugh ML Barsky SH | | 0，，13： | 1 |
| 12 | Isolation and characterization of circulating tumor cells in patients with metastatic colorectal cancer显示文摘 | Cohen SJ Alpaugh RK Gross S | 2006 | Clin Colorectal Cancer2006，6，2： | 1 |
| 13 | Phase Ⅱ and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in pa- tients with metastatic pancreatic adenocarcinoma显示文摘 | Cohen S J Ho L Ranganathan S Abbruzzese J L Alpaugh R K Beard M | 2003 | J Clin On- col2003，21，： | 1 |
| 14 | Isolation and characterization of circulating tumor cells in patients with metastatic colorectal cancer显示文摘 | Cohen SJ Alpaugh RK Gross S | 2006 | Clin Colorectal Cancer2006，6，2： | 1 |
| 15 | Isolation and characterization of circulating tumor cells in patients with metastatic colorectal cancer 显示文摘 | COHEN S J ALPAUGH R K GROSS S | 2006 | Clin Colorectal Cancer2006，6，2： | 1 |
| 16 | An intact overexpressed E-cadherin/alpha, beta-catenin axis characterizes the lymphovascular emboli of inflammatory breast carcinoma 显示文摘 | TOMLINSON J S ALPAUGH M L BARSKY S H | 2001 | Cancer Res2001，61，13： | 1 |
| 17 | Circulating tumor cells: evolving evidence and future challenges显示文摘 | Dotan E Cohen SJ Alpaugh KR | 2009 | Oncologist2009，14，11： | 1 |
| 18 | A novel human xenograft model of inflammatory breast cancer显示文摘 | Tomlinson JS Shao ZM | 1999 | Cancer Researsh1999，59，： | 1 |
| 19 | Isolation and characterization of circulating tumor cells in patients with metastatic colorectal cancer显示文摘 | Cohen S J Alpaugh RK Gross S | 2006 | Clinical colorectal cancer2006，6，2： | 1 |
| 20 | The human myoepithelial cell exerts antiproliferative effects on breast carcinoma cells characterized by p21 WAF1/CIP1 induction, G2/M arrest,and apoptosis 显示文摘 | Shao Z M Nguyen M Alpaugh M L | 1998 | Exp Cell Res1998，241，2： | 1 |
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