|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 3 | Real-time PCR diagnosis of Schistosoma japonicum in low transmission areas of China显示文摘Background:Schistosomiasis in the People’s Republic of China(PRC)can be traced back to antiquity.In the past 60 years,the Chinese government has made great efforts to control this persistent disease with elimination slated by 2020 through the implementation of a comprehensive control strategy.This strategy aims to reduce the role of bovines and humans as sources of infection as a pre-requisite for elimination through transmission interruption.The goal of elimination will be achievable only by the implementation of a sustainable surveillance and control system,with sensitive diagnosis a key feature so that the true disease burden is not underestimated.Currently used diagnostics lack the necessary sensitivity to accurately determine the prevalence of Schistosoma japonicum infection in areas with low infection intensities.It is of critical importance to find and treat people and to identify animals with low-level infections if the National Control Programme for China is to achieve schistosomiasis elimination.Methods:We evaluated a real-time polymerase chain reaction(qPCR)assay using 633 human stool samples collected from five villages in Hunan,Anhui,Hubei,and Jiangxi provinces,and 182 bovine(70 cattle and 112 buffalo)stool samples obtained from four villages in Hunan,Anhui,and Jiangxi provinces in the PRC.All stool samples were subjected to the miracidium hatching test(MHT,a diagnostic procedure used in the National Schistosomiasis Control Programme)and the qPCR assay.Samples positive by MHT were subjected to either the Kato-Katz technique for humans,or the formalin-ethyl acetate sedimentation-digestion(FEA-SD)procedure for bovines,to determine infection intensities.Results:The qPCR assay exhibited a high level of sensitivity in the detection of S.japonicum infections.With both the human and bovine samples,a significantly higher prevalence was determined using the qPCR assay(11.06%humans,24.73%bovines)than with the MHT(0.93%humans,7.69%bovines).The animal contamination index(calculated using data obtained with the qPCR technique)for all positive bovines was 27618000 eggs per day,indicating a considerable amount of environmental egg contamination that would be underestimated using less sensitive diagnostic procedures.Conclusions:The qPCR assay we have evaluated will be applicable as a future field diagnostic and surveillance tool in low-transmission zones where schistosomiasis elimination is targeted and for monitoring post-intervention areas to verify that elimination has been maintained. | Pei He Catherine A.Gordon Gail M.Williams Yuesheng Li Yuanyuan Wang Junjian Hu Darren J.Gray Allen G.Ross Donald Harn Donald P.McManus | 2018 | Infectious Diseases of Poverty2018，7，1： | 7 |
| 4 | Seed Zone Properties and Crop Performance as Affected by Three No-Till Seeders for Permanent Raised Beds in Arid Northwest China显示文摘The no-till seeders of various soil opener configurations have been shown to produce various soil physical responses in relation to soil and climate conditions, thus affecting crop performance in permanent raised beds (PRB) systems. This is particularly important in arid Northwest China where large volumes of residue are retained on the soil surface after harvest. In Zhangye, Gansu Province, China, a field trial assessed the effects of three typical (powered-chopper, powered-cutter and powered-disc) PRB no-till seeders and one traditional seeder on soil disturbance, residue cover index, bulk density, fuel consumption, plant growth, and subsequent yield. In general, seedbed conditions and crop performance for PRB no- till seeders seeded plots were better than for traditional seeded plots. In PRB cropping system, the powered-chopper seeder decreased mean soil disturbance and increased residue cover index compared to powered-disc and -cutter seeders. However, the results indicated that soil bulk density was 2.3-4.8% higher, soil temperature was 0.2-0.6℃ lower, and spring wheat emergence was 3.2-4.7% less. This was attributed to greater levels of residue cover and firmer seedbeds. Spring maize and wheat performance in the powered-cutter and -disc treatments was better (non-significant) than powered-chopper treatment. So powered disc no-till seeder, which generally provided the best planting condition and the highest yield, appeared to be the suitable seeder in heavy residue cover conditions. Considering the precision requirements for soil disturbance and residue cover, the powered strip-chopping no-till seeder could be a suitable option for PRB cropping system in Northwest China. Although these results are preliminary, they are still valuable for the design and selection of no-till seeders for PRB cropping systems in arid Northwest China. | HE Jin LI Hong-wen Allen David McHugh WANG Qing-jie LI Hui Rabi Gautam Rasaily Khokan Kumer Sarker | 2012 | Journal of Integrative Agriculture2012，11，10： | 5 |
| 5 | Design and experiment of anti-vibrating and anti-wrapping rotary components for subsoiler cum rotary tiller显示文摘The commonly used subsoiling cum rotary tiller machine(SRT)in Northern China is a combination of subsoiler and horizontal rotary tiller,however backfilling of the subsoiling slot,excessive vibration and plant residue wrapping on rotary components has been rarely considered.Therefore,the rotary components and assembly were redesigned to address these issues and to an SRT fitted with IT225 short curve rotary blades behind the V-shape subsoiling slots and IIT245 long curve rotary blades between the tines.Long and short blades were fitted on a rotor in a double helix,with optimal spiral angles of 65° and 90°,and phase angle of 147°and 180°,respectively.Compared with the commonly used SRT(CSRT),the additional anti-wrapping cutting blades in the circumferential and axial direction of ASRT could remove hanging residue on the blade holders,wrapping on the rotor and formation of an isolation layer.Moreover,the cutting edge curve of anti-wrapping cutting blades was an exponential curve.Field tests demonstrated that the redesigned SRT with anti-vibrating and anti-wrapping rotary components(ASRT)had was a significant advancement over the CSRT.Moreover,the working depth of rotary tillage was more stable,while other observations confirmed that backfilling of the subsoiling slot was also improved. | Kan Zheng Allen D.McHugh Hongwen Li Qingjie Wang Caiyun Lu Hongnan Hu Wenzheng Liu Zhiqiang Zhang Peng Liu Jin He | 2019 | International Journal of Agricultural and Biological Engineering2019，12，4： | 4 |
| 6 | 粉红粘帚菌代谢物对南方根结线虫卵孵化及二龄幼虫的影响(英文)显示文摘粉红粘帚菌(Gliocladium spp.)是一类对植物病原菌具有潜在生物控制作用的真菌,为了探讨粘帚菌对南方根结线虫(Meloidogyne incognita)的抑制作用,实验室条件下研究了粉红粘帚菌挥发性代谢产物和非挥发性代谢产物不同稀释度对南方根结线虫卵孵化及二龄幼虫活性的影响。结果显示非挥发性代谢产物在原液、5倍、10倍、20倍、50倍稀释浓度下,12 d后对南方根结线虫卵孵化的相对抑制率分别为80.4%、12.0%、10.5%、6.7%和5.2%,对二龄幼虫的矫正死亡率分别为32.0%、9.3%、2.0%、0.6%和0.1%,与对照组相比差异显著;挥发性代谢产物对南方根结线虫卵孵化的相对抑制率为22.5%,对二龄幼虫的相对死亡率为17.4%。因此,粉红粘帚菌的非挥发性和挥发性代谢产物对南方根结线虫卵孵化及二龄幼虫活性均有一定的抑制作用。 | 王丽芳 许艳丽 LI Shu-xian 李春杰 Allen G. Xue | 2011 | 大豆科学2011，30，5： | 3 |
| 7 | In-Situ SHRIMP U-Pb Dating of Xenotime Outgrowth on Detrital Zircon Grains from the Changzhougou Formation of the Ming Tomb District, Beijing显示文摘SHRIMP U-Pb dating of diagenetic xenotime from sedimentary rocks has provided age constraints for sedimentary diagenesis(Mc Naughton et al.,1999;Fletcher et al.,2000;England et al.,2001;Rasmussen et al.,2004;Vallini et al.,2007).Xenotime(YPO4)may grow during early diagenesis,typically being present as a trace constituent in siliciclastic sedimentary rocks(Rasmussen,2005),in the form of syntaxial outgrowths on detrital zircon grains.Diagenetic xenotime occurs in | SHI Yuruo Kennedy ALLEN Aleinikoff JOHN SONG Tianrui LI Linlin SUN Huiyi | 2015 | Acta Geologica Sinica(English Edition)2015，89，1： | 3 |
| 8 | Micro-optical fabrication by ultraprecision diamond machining and precision molding显示文摘 | Likai LI Neil J. NAPLES Jeffrey W. ROBLEE Allen Y. YI | 2017 | Frontiers of Mechanical Engineering2017，12，2： | 2 |
| 9 | Distribution pattern of the snail intermediate host of schistosomiasis japonica in the Poyang Lake region of China显示文摘Background:With the closure of the Three Gorges Dam in 2003 the hydrology of Poyang Lake was altered dramatically leading to significant changes in the environment.In order to assess the impact on schistosomiasis this study assessed the spatial and temporal patterns of the snail intermediate host,Oncomelania hupensis in the Poyang Lake tributaries.The results of the study have important implications for future snail control strategies leading to disease elimination.Methods:The marshland area surrounding Poyang Lake was divided randomly into 200×200 m vector grids using ArcGIS software,and the surveyed grids were randomly selected by the software.The snail survey was conducted in each selected grid using a survey frame of 50×50 m with one sideline of each grid serving as the starting line.No less than ten frames were used in each surveyed grid with Global Positioning System(GPS)recordings for each.All snails in each frame were collected to determine infection status by microscopy.Altitude data for all frames were extracted from a lake bottom topographic map in order to analyze the average altitude.All snail survey data were collected and statistically analyzed with SPSS 20.0 software in order to determine the difference of the percentage of frames with living snails and mean density of living snails in different regions of Poyang Lake.The altitude of the snail-infested marshlands and snail dens were subsequently identified.Results:A total of 1159 potential snail sampling grids were surveyed,of which 15231 frames(0.1 m2/frame)were investigated.1241 frames had live Oncomelania snails corresponding to 8.15%of the total number of frames.The mean density of living snails was 0.463/0.1 m2 with a maximum of 57 snails per frame.The percent of frames with snails in the southern sector(8.13%)of Poyang Lake did not differ statistically from the north(8.21%).However,the mean density of live snails in the northern sector(0.164/0.1 m2)of the lake was statistically higher(F=6.727;P=0.010)than the south(0.141/0.1 m2).In the south of the lake,the elevation of snail-inhabited marshland ranged between 11-16 m,and could be further subdivided into two snail-concentrated belts at 12-13 m of elevation and 15-16 m of elevation respectively.In the north of the lake,the elevation of snail-inhabited marshland ranged between 9-16 m with the elevation of 12-14 m being the snail-concentrated zone.Conclusions:The elevation of snail-infested marshlands in the Poyang Lake region ranged from 9 to 16 m.The snail distribution and habitat has moved north of the lake and to a lower altitude due to changes in the water level post dam closure.Based on the current geological features of the snail habitant focused mollusciciding should occur in snail dense northern regions with frequent bovine and human traffic.Targeting these identified'hotspots'of transmission will assist in elimination efforts. | Fei Hu Jun Ge Shang-Biao Lv Yi-Feng Li Zhao-Jun Li Min Yuan Zhe Chen Yue-Ming Liu Yue-Sheng Li Allen G.Ross Dan-Dan Lin | 2019 | Infectious Diseases of Poverty2019，8，2： | 2 |
| 10 | Source-sink relations and responses to sink-source manipulations during grain filling in wheat显示文摘The source-sink ratio during grain filling is a critical factor that affects crop yield in wheat,and the main objective of this study was to determine the source-sink relations at both the canopy scale and the individual culm level under two nitrogen(N)levels at the post-jointing stage.Nine widely-used cultivars were chosen for analyzing source-sink relations in southwestern China;and three typical cultivars of different plant types were subjected to artificial manipulation of the grain-filling source-sink ratio to supplement crop growth measurements.A field experiment was conducted over two consecutive seasons under two N rates(N+,150 kg ha^(-1);N-,60 kg ha^(-1)),and three manipulations were imposed after anthesis:control(Ct),removal of flag and penultimate leaves(Lr)and removal of spikelets on one side of each spike(Sr).The results showed that the single grain weights in the three cultivars were significantly decreased by Lr and increased by Sr,which demonstrated that wheat grain yield potential seems more source-limited than sink-limited during grain filling,but the source-sink balance was obviously changed by climatic variations and N deficient environments.Grain yield was highly associated with sink capacity(SICA),grain number,biomass,SPAD values,and leaf area index during grain filling,indicating a higher degree of source limitation with an increase in sink capacity.Therefore,source limitation should be taken into account by breeders when SICA is increased,especially under non-limiting conditions.Chuanmai 104,a half-compact type with a mid-sized spike and a long narrow upper leaf,showed relatively better performance in source-sink relations.Since this cultivar showed the characteristics of a lower reduction in grain weight after Lr,a larger increase after Sr,and a lower reduction in post-anthesis dry matter accumulation,then the greater current photosynthesis during grain filling contributed to the grain after source and sink manipulation. | WU Xiao-li LIU Miao LI Chao-su Allen David(Jack)MCHUGH LI Ming XIONG Tao LIU Yu-bin TANG Yong-lu | 2022 | Journal of Integrative Agriculture2022，21，6： | 2 |
| 11 | Autophagy is a key feature in the pathogenesis of systemic sclerosis显示文摘 | Tracy Frech Ivana Domenico Maureen A. Murtaugh Monica P. Revelo Dean Y. Li Allen D. Sawitzke Stavros Drakos | 2014 | Rheumatology International2014，，3： | 1 |
| 12 | Bioavailability of slowly cycling soil phosphorus:major restructuring of soil P fractions over four decades in an aggrading forest显示文摘 | RICHTER D D ALLEN H L LI J | 2006 | Oecologia2006，150，2： | 1 |
| 13 | Ketamine anesthesia during the first week of life can cause long- lasting cognitive deficits in rhesus monkeys显示文摘 | Paule MG Li M Allen RR Liu F Zou X Hotchkiss C | 2011 | Neurotoxicol Ter- atol2011，33，2： | 1 |
| 14 | Saxagliptin added to a thiazolidinedione improves glycemic control in patients with type 2 diabetes and inadequate control on thiazolidinedione alone 显示文摘 | Hollander P Li J Allen E | 2009 | J Clin Endocrinol Metab2009，94，12： | 1 |
| 15 | Micromilling of thin ribs with high aspect ratios显示文摘 | P Li D Zdebski H H Langen A M Hoogstrate J A J Oosterling R H Munnig Schmidt D M Allen | 2010 | Journal of Micromechanics and Microengineering2010，，11： | 1 |
| 16 | Sedimentary responses to thrusting and strike-slipping of Longmen Shan along Eastern Margin of Tibetan Plateau, and their implication of Cimmerian continents and India/Eurasia collision 显示文摘 | Li Yong Densmore A L Allen P A | 2001 | Scientia Geologica Sinica2001，10，4： | 1 |
| 17 | Influence of co-culture during maturation on the developmental potential of equine oocytes fertilized by intracytoplasmic sperm injection (ICSI)显示文摘 | Li X Morris L H Allen W R | 2001 | Reproduction2001，121，： | 1 |
| 18 | SHRIMP U–Pb zircon geochronological and geochemical evidence for Neoproterozoic arc-magmatism along the western margin of the Yangtze Block, South China显示文摘 | Mei-Fu Zhou Dan-Ping Yan Allen K Kennedy Yunqian Li Jun Ding | 2002 | Earth and Planetary Science Letters2002，，1： | 1 |
| 19 | A psychoacoustic method for studying the necessary and sufficient perceptual cues of American English fricative consonants in noise 显示文摘 | Li F Trevino Allen | 2012 | Journal of the Acoustical Society of America2012，132，4： | 1 |
| 20 | rhBMP -2, rhVEGF (165), rhPTN and thrombin-related peptide, TP508 induce chemotaxis of human osteoblasts and microvascular endothelial ceils 显示文摘 | LI G CUI Y MCILMURRAY L ALLEN WE | 2005 | J Orthop Res2005，23，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员