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3篇 您的检索式：作者名="Alla Skapenko"

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		题名	作者	年代	出处	被引量
	1	Im-munomodulatory functions of leflunomide:inhibition of T helper (Th) lcell activation and promotion of th2differentiation显示文摘	Petya Dimitrova Alla Skapenko Rudolf Schleyerbach	2001	Arthritis & Rheuma-tism2001，44，9：	1
	2	Tmmunomodulatory fu nctions of leflunomide:imhibition of T helper(Th)l cell activation and promotio n of Th 2differentiation显示文摘	Rudolf schleyerbach	2001	Arthritis & Rheuma tism2001，，4419：	1
	3	Dysregulated immunity in PID patients with low GARP expression on Tregs due to mutations in LRRC32显示文摘Immune dysregulation diseases are characterized by heterogeneous clinical manifestations and may have severe disease courses.The identification of the genetic causes of these diseases therefore has critical clinical implications.We performed whole-exome sequencing of patients with immune dysregulation disorders and identified two patients with previously undescribed mutations in LRRC32,which encodes glycoprotein A repetitions predominant(GARP).These patients were characterized by markedly reduced numbers and frequencies of regulatory T cells(Tregs).Tregs with mutated LRRC32 exhibited strongly diminished cell-surface GARP expression and reduced suppressor function.In a model of conditional Garp deficiency in mice,we confirmed increased susceptibility to inflammatory diseases once GARP expression on Tregs was decreased.Garp deficiency led to an unstable Treg phenotype due to diminished Foxp3 protein acetylation and stability.Our study reinforces the understanding of the immunological mechanisms of immune dysregulation and expands the knowledge on the immunological function of GARP as an important regulator of Treg stability.	Peter Lehmkuhl Magdalena Gentz Andres Caballero Garcia de Otezya Bodo Grimbacher Hendrik Schulze-Koops Alla Skapenko	2021	Cellular & Molecular Immunology2021，18，7：	1

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