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| 1 | Identification of CD13,CD107a,and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-de-pendent upregulation显示文摘Using two-colour flow cytometry >200 antibodies submitted to the 8th International Workshop of Human Leukocyte Differentiation Antigens (HLDA8) have been analyzed for their reactivity with resting and activated CD203c+ basophils. Four antibodies either non-reactive or weakly reactive with resting basophils exhibited an increased reactivity with basophils activated by anti-IgE-mediated cross-linking of the high affinity IgE receptor (FcεRI). These include antibod- ies against CD164 (WS-80160, clone N6B6 and WS-80162, clone 67D2), as well as two reagents with previously unknown specificities that were identified as CD13 (WS-80274, clone A8) and CD107a (WS-80280, clone E63-880). The activation patterns followed either the “CD203c-like” or “CD63-like” activation profile. The CD203c profile is characterized by a rapid and significant upregulation (of CD13, CD164, and CD203c), reaching maximum levels after 5- 15 min of stimulation. The phosphoinositide-3-kinase (PI3K)-specific inhibitor wortmannin inhibited the upregulation of these markers whereas 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced a rapid and FcεRI-independent upregulation within 1-2 min. In the CD63 profile, maximum upregulation (of CD63 and CD107a) was detected only after 20-40 min, and upregulation by TPA reached maximum levels after 60 min. In summary, our data identify CD13, CD107a, and CD164 as novel basophil-activation antigens. Based on time kinetics of upregulation, we hypothesize that molecules of the “CD203c group” and the “CD63 group” are linked to two different mechanisms of basophil activation. | Florian HENNERSDORF Stefan FLORIAN Andreas JAKOB Katharina BAUMGRTNER Karoline SONNECK Alfred NORDHEIM Tilo BIEDERMANN Peter VALENT Hans-Jrg BüHRING | 2005 | Cell Research2005，15，5： | 9 |
| 2 | Spilodiclofen and spiromesifen 显示文摘 | Ralf N Thomais B Alfred E | 2003 | Pesticide Outlook2003，，12： | 1 |
| 3 | Process-based software risk assessment显示文摘 | Alfred B | 1995 | Software Process Technology1995，，： | 1 |
| 4 | Differential expression of chemokines in normal pancreas and in chronic pancreatitis显示文摘 | Leslie Saurer Peter Reber Thomas Schaffner Markus W. Büchler Caroline Buri Andreas Kappeler Alfred Walz Helmut Friess Christoph Mueller | 2000 | Gastroenterology2000，，2： | 1 |
| 5 | Carbon foam derived from various precursors显示文摘 | CHONG CHEN ELLIOT B KENNEL ALFRED H STILLER | 2006 | Carbon2006，44，： | 1 |
| 6 | Quality Control with Reli- ability for Large GPS Network显示文摘 | Alfred L Emmons M B | 1994 | Journal of Sur- veying Engineering1994，120，1： | 1 |
| 7 | Market Segmentation by Personal Values and Salient Product Attributes显示文摘 | Alfred S B | 1981 | Journal of Advertising Research1981，21，1： | 1 |
| 8 | Alkane reactions with photoactivated decatungstate in neutral and acid solutipn molecular orbital theory显示文摘 | JEN S F ALFRED B HILL C L | 1992 | J Phys Chem1992，96，： | 1 |
| 9 | Alteration of hemodynamics in aneurysm models by stenting: influence of stent porosity显示文摘 | BARUCH B ALFRED P AJAY K | 1997 | Annals of Biomedical Engineering1997，25，： | 1 |
| 10 | A generic framework for spatial prediction of variables based on regression-kriging显示文摘 | Tomislav Hengl Gerard B M Heuvelink Alfred Stein | 2004 | Geoderma2004，120，： | 1 |
| 11 | Self - assembly of bipolar amphiphiles 显示文摘 | ANNETFE M ALFRED B | 2007 | Curt Opin Colloid Interface Sci2007，12，： | 1 |
| 12 | Differential expression of chemokines in normal pancreas and in chronic pancreatitis显示文摘 | Leslie Saurer Peter Reber Thomas Schaffner Markus W. Büchler Caroline Buri Andreas Kappeler Alfred Walz Helmut Friess Christoph Mueller | 2000 | Gastroenterology2000，，2： | 1 |
| 13 | Tillage nitrogen fertilization influence grain and soil nitrogen in annual cropping system显示文摘 | Ardell D H Alfred L B | 2001 | Agronomy Journal2001，93，： | 1 |
| 14 | Snow load effect on the Earth's Rotation and Gravitational Field, 1979 ~ 1985 显示文摘 | Chao B F William P O'Connor Alfred T C Chang | 1987 | Journal of Geophysical Research1987，92，9： | 1 |
| 15 | Development of Coherent Laser Radar at Lincoln Laboratory 显示文摘 | Alfred B Gschwendtner William E Keicher | 2000 | Lin- coln Laboratory Journal2000，12，2： | 1 |
| 16 | Embedded ties and acquisition of competitive capabilities显示文摘 | McEvily B Alfred Marcus | 2005 | Strategic Management Journal2005，，26： | 1 |
| 17 | Diagnosis and staging of ovarian cancer:comparative values of Doppler and conventional US,CT and MRI imaging correlated with surgery and histopathology analysis-report of the radiology diagnostic oncology group显示文摘 | Alfred B John V Clare M | 1999 | Radiology1999，212，： | 1 |
| 18 | Educational opportunities :a nursing school model for medical special-needs sheltering显示文摘 | Deal B Alfred D Fountain R | 2010 | Nurse Educ2010，35，3： | 1 |
| 19 | Interferon-gamma release as- say for detection of tuberculosis infection 显示文摘 | Alfred A Lardizabal MD Lee B | 2006 | US Respiratory Dis- ease2006，54，6： | 1 |
| 20 | Factors influencing serum levels and peritoneal clearances of low molecular weight proteins in continuous ambulatory peritoneal dialysis显示文摘 | Andre K Eric G Alfred B | 1995 | Kidney Int1995，48，6： | 1 |
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