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| 1 | Origin and evolution of ore-forming fluid for the Gaosongshan gold deposit, Lesser Xing’an Range:Evidence from fluid inclusions,H-O-S-Pb isotopes显示文摘Epithermal gold deposits are typical precious metal deposits related to volcanic and subvolcanic magmatism.Due to the lack of direct geological and petrographic evidences,the origin of the ore-forming fluid is deduced from the spatial diagenesis-mineralization relationship,chronological data,physicochemical characteristics of mineral fluid inclusions,mineral or rock elements and isotopic geochemical characteristics.By objectively examining this scientific problem via a geological field survey and petrographic analysis of the Gaosongshan epithermal gold deposit,we recently discovered and verified the following points:(1) Pyrite-bearing spherical quartz aggregates (PSQA) occur in the rhyolitic porphyry;(2) the mineralization is structurally dominated by WNW- and ENE-trending systems and occurs mostly in hydrothermal breccias and pyrite-quartz veins,and the ore types are mainly hematite-crusted quartz,hydrothermal breccia,massive pyrite-quartz,etc.;(3) the alteration types consist of prevalent silicification,sericitization,propylitization and carbonation,with local adularization and illitization.The ore minerals are mainly pyrite,primary hematite,native gold,and electrum,with lesser amounts of chalcopyrite,magnetite,sphalerite,and galena,indicating a characteristic epithermal low-sulfidation deposit.The ore-forming fluid may have been primarily derived from magmatic fluid exsolved from a crystallizing rhyolitic porphyry magma.Further zircon U-Pb geochronology,fluid inclusion,physicochemical and isotopic geochemical analyses revealed that (1) rhyolitic porphyry magmatism occurred at 104.6 ± 1.0 Ma,whereas the crystallization of the PSQA occurred at 100.8 ± 2.1 Ma;(2) the hydrothermal fluid of the pre-ore stage was an exsolved CO2-bearing H2O-NaCl magmatic fluid that produced inclusions mainly composed of pure vapor (PV),vapor-rich (WV) and liquid-rich (WL) inclusions with a small number of melt-(M) and solid-bearing (S) inclusions;mineralization-stage quartz contains WL and rare PV,WV and pure liquid (PL) inclusions characterized by the H2O-NaCl system with low formation temperatures and low salinities;(3) the characteristics of hydrogen,oxygen,sulfur,and lead isotopes and those of rare earth elements (REEs) provide insight into the affinity between PSQA and orebodies resulting from juvenile crust or enriched mantle.Combined with previous research on the mineralogenetic epoch (99.32 ± 0.01 Ma),we further confirm that the mineralization of the deposit occurred in the late Early Cretaceous,which coincides with the extension of the continental margin induced by subduction of the Pacific Plate beneath the Eurasian Plate.The formation of the ore deposit was proceeded by a series of magmatic and hydrothermal events,including melting of enriched juvenile crust,upwelling,the eruption and emplacement of the rhyolitic magma,the exsolution and accumulation of magmatic hydrothermal fluid,decompression,the cooling and immiscibility/boiling of the fluid,and mixing of the magmatic fluid with meteoric water,in association with water-rock interaction. | Yang Liu Jinggui Sun Jilong Han Liang Ren Alei Gu Keqiang Zhao Changshen Wang | 2019 | Geoscience Frontiers2019，10，5： | 3 |
| 2 | Hypoxia induces T-cell apoptosis by inhibiting chemokine C receptor 7 expression:the role of adenosine receptor A2显示文摘Hypoxia is a major characteristic of the tumor microenvironment,and its effects on immune cells are proposed to be important factors for the process of tumor immune escape.It has been reported that hypoxia affects the function of dendritic cells and the antitumor function of T cells.Here we discuss the effects of hypoxia on T-cell survival.Our results showed that hypoxia induced apoptosis of T cells.Adenosine and adenosine receptors(AR)are important to the hypoxia-related signaling pathway.Using AR agonists and antagonists,we demonstrated that hypoxia-induced apoptosis of T cells was mediated by A^(2a)and A^(2b)receptors.Furthermore,we are the first,to our knowledge,to report that hypoxia significantly inhibited the expression of chemokine C receptor 7(CCR7)of T cells via the A^(2)R signal pathway,perhaps representing a mechanism of hypoxia-induced apoptosis of T cells.Collectively,our research demonstrated that hypoxia induces T-cell apoptosis by the A^(2)R signaling pathway partly by suppressing CCR7.Blocking the A^(2)R signaling pathway and/or activation of CCR7 can increase the anti-apoptosis function of T cells and may become a new strategy to improve antitumor potential. | Jintang Sun Yan Zhang Meixiang Yang Yun Zhang Qi Xie Zewu Li Zhaogang Dong Yongmei Yang Biping Deng Alei Feng Weixu Hu Haiting Mao Xun Qu | 2010 | Cellular & Molecular Immunology2010，7，1： | 3 |
| 3 | Preparation and electrochemical property of CMC/MWCNT composite using ionic liquid as solvent显示文摘Carboxymethyl cellulose sodium(CMC)/multi-walled carbon nanotube(MWCNT) composite was prepared by dissolving CMC with ionic liquid as solvent.The microstructure and electrochemical properties of CMC/MWCNTs were studied using field emission scanning electron microscopy(FE-SEM),high-resolution transmission electron microscopy(HR-TEM),X-ray diffraction(XRD) system and electrochemical workstation.The experimental results indicated that the CMC dissolved with ionic liquid could be uniformly enwrapped on the surface of MWCNTs,and the coating thickness of CMC was about 5.4 nm.There are obvious oxidation peaks in the cyclic voltammograms curves of glassy carbon electrode coated with a CMC/MWCNT composite in H2O2 phosphate buffer solution.The MWCNT content and ultrasonic time strongly affected the dispersivity and electrochemical property of CMC/MWCNT composite.While the MWCNT content and ultrasonic processing time was 2 wt% and 2 h respectively,CMC/MWCNT composite exhibited excellent electrocatalytic activity. | ZHAO TingKai LIU LeHao LI GuangMing DU Li ZHAO Xing YAN Jin CHENG YouLiang DANG ALei LI TieHu | 2012 | Chinese Science Bulletin2012，57，14： | 3 |
| 4 | Osteopontin splice variants expressed by breast tumors regulate monocyte activation via MCP-1 and TGF-β1显示文摘Osteopontin (OPN ) ,多功能的 glycoprotein,有在 vitro 在肿瘤有不同角色的三个抄本。OPN 抄本是否在 vivo 在肿瘤进程有不同函数,是不清楚的。有免疫力的导出房间的 OPN 能支持肿瘤形成,这被报导了。我们建议导出肿瘤的 OPN 可以便于的一个假设由影响有免疫力的房间区别和功能的肿瘤免疫者逃跑。在这研究,我们构造了 OPN 抄本和 transfected 的 lentiviral 表示向量他们进 MCF-7 房间线。有 OPN 抄本的 MCF-7 房间 transfected 被注入裸体老鼠的腋窝,并且肿瘤生长被监视。结果证明所有 OPN 抄本支持了本地肿瘤形成,而是那在抄本之中没有重要差别。我们也调查了 coculturing 单核白血球肿瘤房间与肿瘤上层清液在单核白血球区别上表示的 OPN 的效果。我们与 OPN 相比发现 OPN-c upregulated CD163 层次 --and OPN-b;然而,任何一个都没抄本影响 HLA 医生和 CD206 层次。所有 OPN 抄本显著地禁止了 TNF-α并且由单核白血球提高了 IL-10 生产。而且,我们发现了 OPN 抄本的 overexpression 显著地 upregulated TGF-β 1 并且由肿瘤房间的 MCP-1 生产。用抵销抗体和 recombinant cytokines,我们发现由肿瘤房间的 OPN overexpressed 调整 TNF-α 的生产;并且由单核白血球的 IL-10 部分经由 MCP-1 和 TGF-β 1 分别地。一起,我们的结果证明 OPN 抄本没在 vivo 在乳癌形成有不同角色。我们也证明 OPN 经由 TGF-β 调整单核白血球的其他的激活; 1 并且 MCP-1,它可以为肿瘤代表另外的机制免疫者逃跑。 | Jintang Sun Alei Feng Songyu Chen Yun Zhang Qi Xie Meixiang Yang Qianqian Shao Jia Liu Qifeng Yang Beihua Kong Xun Qu | 2013 | Cellular & Molecular Immunology2013，10，2： | 2 |
| 5 | Combination of ARTP mutagenesis and color-mediated highthroughput screening to enhance 1-naphthol yield from microbial oxidation of naphthalene in aqueous system显示文摘Strain QCG of the aerobic bacteria Bacillus cereus is capable of producing l-naphthol from naphtha-lene,this strain was first isolated and characterized in this study.Strain QCG was mutagenized to enhance l-naphthol production,using atmospheric and room temperature plasma(ARTP)technology.Then,a microbial clone screening system was used to accelerate the operation.Meanwhile,a novel color-mediated high-throughput screening using 4-aminoantipyrine was performed to screen mutants.The optimal mutant strain QCG4 produced 19.58土0.34 mg·L-1-naphthol from naphthalene that was 47.32%higher than that of the original strain(13.29+0.28 mg·L-1).In addition,the optimal conditions for l-naphthol production via whole-cell catalysis of strain QCG4 were determined to be an OD600 of40,150 mg.L I naphthalene,and 7.5%dimethyl formamide as a co-solvent at pH 7.5 and 26℃ for 3 h,resulting in 41.18士0.12 mg·L-l-naphthol,i.e.,the mutant strain produces a 2.1-fold higher yield compared to the original strain. | Chenggang Qiu Alei Zhang Sha Tao Kang Li Kequan Chen Pingkai Ouyang | 2020 | Frontiers of Chemical Science and Engineering2020，14，5： | 2 |
| 6 | Culture media for Ral- stonia solanacearum isolation, identification and maintenance 显示文摘 | French E R Gutarra L Aley P | 1995 | Fitopatolgia1995，30，3： | 1 |
| 7 | An improved enrichment broth for the sensitive detection of Ralstonia solanacearum (biovars 1 and 2A)in soil using DAS-ELISA显示文摘 | Priou S Gutarra L Aley P | 2006 | Plant Pathology2006，55，1： | 1 |
| 8 | Disinfection of gram-negative and gram-positive bacteria using D yna J ets ? hydrodynamic cavitating jets显示文摘 | Gregory Loraine Georges Chahine Chao-Tsung Hsiao Jin-Keun Choi Patrick Aley | 2011 | Ultrasonics - Sonochemistry2011，，3： | 1 |
| 9 | Different peripheral mechanisms mediate en- hanced nociception in metabilic/toxic and traumatic painful periph- eral neuropathies in the rat 显示文摘 | Aley KC Levine JD | 2002 | Neuroscience2002，111，： | 1 |
| 10 | 显示文摘 | Aley O Levine JD | 2003 | Exp Brain Res2003，148，4： | 1 |
| 11 | Different peripheral mechanisms mediate en- hanced nociception in metabolic/toxic and traumatic painful pe- ripheral neuropathies in the rat显示文摘 | Aley K O Levine J D | 2002 | Neuroscience2002，111，2： | 1 |
| 12 | Adenoasociated and herpes simple virusas vector for gene transfer to the corneal endothelium显示文摘 | Hudde T Rayner SA Aleis MD Thrasher AJ Smith J Coffin RS | 2000 | Cornea2000，19，： | 1 |
| 13 | Killing of Giardia lamblia by cryptdins and cationic neutrophil peptides 显示文摘 | Aley SB Zimmerman M Hetsko M | 1994 | Infect Immun1994，62，12： | 1 |
| 14 | Noceptor sensitization by extracellular signal-regulated kinase显示文摘 | Aley K O Martin A McMahon T | 2001 | J Neurosci2001，21，17： | 1 |
| 15 | Different peripheral mechanisms mediate enhanced nociception in metabolic/toxic and traumatic painful peripheral neuropathies in the rat显示文摘 | Aley KO Levine JD | 2002 | Neuroscience2002，111，2： | 1 |
| 16 | Highly sensitive detection of Ralstonia solanacearurn in latterly infected potato tubers by post-enrichment enzyme-linked immunosorbent assay on nitrocellulose mernbrane显示文摘 | PRRIOU S GUTARRA L ALEY P | 1999 | Bulletin OEPP/EPPO Bulletin1999，29，： | 1 |
| 17 | To produce rapidly disintegrating Tenoxi- cam tablets via camphor sublimation显示文摘 | Aley AM Semreen M Qato MK | 2005 | Pharm TechM2005，3，2： | 1 |
| 18 | Petrology and chemistry of metasomatic blocks from Bawshir,northeastern Oman显示文摘 | Aley K El-Shazly Mohammed Al-Belushi | | 0，，： | 1 |
| 19 | Killing of Giardia lamblia by cryptdins and cationic neutrophil peptides显示文摘 | Aley SB Zimmerman M Hetsko M | 1994 | Infect Immun1994，62，12： | 1 |
| 20 | An improved enrichment broth for the sensitive detection of Ralstonia solanacearum (biovars 1 and 2A) in soil using DAS -ELISA 显示文摘 | Priou S Gutarra L Aley P | 2006 | Plant Pathology2006，55，1： | 1 |
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