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1新媒体联盟地平线报告:2017高等教育版显示文摘《新媒体联盟地平线报告:2017高等教育版》由美国新媒体联盟与美国高校教育信息化协会学习促进会协作完成。来自5大洲22个国家的78位不同角色的专家选择了最有可能影响今后五年(2017—2021)技术规划和决策制定的六项主要趋势、六个关键挑战和六种重要技术,详细阐释了共18个主题的内容。本年度报告将18个主题内容分为六个元分类,并对每个内容进行元分类标注。从2017年的报告当中,我们既能够见到'混合式学习'、'自适应性学习'、'移动学习'等熟悉的主题,又能够看到'人工智能'、'自然用户界面'等新兴技术的最新进展。本报告对于指导各国政府和高等院校推进教育信息化工作具有宏观指导价值。S·亚当斯贝克尔 M·卡明斯 A·戴维斯 A·弗里曼 C·霍尔给辛格 V·安娜塔娜额亚婻 殷丙山(译) 高茜(译) 任直(译) 刘鑫驰(译) 曹红岩(译) 王济军(译) 赵广元(译) 邵恒(译) 2017开放学习研究2017,22,2:81
2Portal vein thrombosis:Insight into physiopathology,diagnosis,and treatment显示文摘Portal vein thrombosis (PVT) is a relatively common complication in patients with liver cirrhosis, but might also occur in absence of an overt liver disease. Several causes, either local or systemic, might play an important role in PVT pathogenesis. Frequently, more than one risk factor could be identified; however, occasionally no single factor is discernable. Clinical examination, laboratory investigations, and imaging are helpful to provide a quick diagnosis, as prompt treatment might greatly affect a patient's outcome. In this review, we analyze the physiopathological mechanisms of PVT development, together with the hemodynamic and functional alterations related to this condition. Moreover, we describe the principal factors most frequently involved in PVT development and the recent knowledge concerning diagnostic and therapeutic procedures. Finally, we analyze the implications of PVT in the setting of liver transplantation and its possible influence on patients' future prognoses.Francesca R Ponziani Maria A Zocco Chiara Campanale Emanuele Rinninella Annalisa Tortora Luca Di Maurizio Giuseppe Bombardieri Raimondo De Cristofaro Anna M De Gaetano Raffaele Landolfi Antonio Gasbarrini 2010World Journal of Gastroenterology2010,16,2:75
3晚新生代岷江下蚀速率及其对青藏高原东缘山脉隆升机制和形成时限的定量约束显示文摘青藏高原东缘具有青藏高原地貌、龙门山高山地貌和山前冲积平原三个一级地貌单元 ,本文以岷江作为切入点 ,研究了该地区河流下蚀速率与山脉的隆升作用之间的相互关系。在建立岷江阶地序列的基础上 ,利用阶地高程和热释光年代学测年资料分别定量计算了岷江在川西高原、龙门山和成都盆地的下蚀速率 ,结果表明岷江各河段的下蚀速率明显不同 ,分别为 1.0 7~ 1.6 1mm / a、1.81m m/ a和 0 .5 9mm / a;在龙门山地区岷江的下蚀速率最高 ,约为川西高原地区的 1.5倍 ,约为成都平原地区的 3倍 ;而同一河段不同时期岷江的下蚀速率基本是连续的 ,具有很好的线性关系 ,可作为该河段整个河谷的下蚀速率。基于龙门山的表面隆升速率 (0 .3~ 0 .4 mm / a) ,在约束局部侵蚀基准面和气候变化对阶地形成的控制作用的基础上 ,本文建立了青藏高原东缘岷江下蚀速率与龙门山表面隆升速率之间的线性关系 ,结果表明河流下蚀速率约为山脉表面隆升速率的 5倍。根据龙门山表面在隆升速率和下切速率等方面均大于川西高原 ,并结合龙门山活动构造以走滑作用为主 ,笔者认为青藏高原东缘的边缘山脉以剥蚀隆升为主 ,兼有构造隆升作用。最后 ,根据岷江最大切割深度所需的时间 (3.4 8Ma)和成都盆地最古老的岷江冲积扇大邑砾岩的时间 (3.6李勇 曹叔尤 周荣军 AL DENSMORE M A ELLIS 2005地质学报2005,79,1:70
4青藏高原东缘龙门山晚新生代走滑挤压作用的沉积响应显示文摘成都盆地位于青藏高原东缘,夹于龙门山与龙泉山之间,盆地的长轴方向平行于龙门山,呈现为北东—南西向展布的线性盆地。盆地中充填了3.6Ma以来的半固结—松散堆积物,最大厚度为541m,在垂向上由下部的大邑砾岩、中部的雅安砾石层和上部的上更新统至全新统砾石层组成,其与下覆地层均为不整合接触,显示该盆地是一个单独的成盆期,并非是在中生代前陆盆地基础上形成的继承性盆地。在垂直于龙门山造山带方向上,成都盆地具不对称的楔形结构,沉积基底面整体向西呈阶梯状倾斜,盆地中充填的碎屑物质均来源于盆地西侧的龙门山,具横向水系和单向充填的特征;而且盆地的沉降中心具有逐渐向远离造山带方向迁移的特征,显示盆地的挤压方向垂直于龙门山主断裂,造成了成都盆地在垂直于造山带方向上的构造缩短。在平行于龙门山造山带方向上,成都盆地具有一系列的北东向延伸的次级凸起和凹陷,凹陷和凸起相间分布,且在空间上呈斜列形式展布于盆地的底部,其中次级凹陷(沉降中心)和冲积扇具有向平行龙门山造山带方向迁移的特征,表明成都盆地西缘的龙门山断裂具有右旋走滑的特征。鉴于以上特征,认为成都盆地是在龙门山造山带晚新生代走滑与逆冲的联合作用下形成的走滑挤压盆地。李勇 周荣军 Densmore A L Ellis M A 黎兵 2006沉积学报2006,24,2:65
5BCLC策略:预后预测和治疗推荐2022版更新显示文摘2018版BCLC预后和治疗推荐策略发布后,肝细胞癌(简称HCC)的研究又取得了重大进展。本次更新基于肝癌各领域的研究进展结果。重点关注影响策略的重要研究进展。虽然近年的研究结果成绩斐然,但将其引入为临床医生和研究者提供行动依据的循证模型指南来说证据效力依然不够确切。本文对该问题进行分析,阐述了为HCC患者制定个体化治疗临床决策所需的批判性思维和专业知识。Reig M Forner A Rimola J Ferrer-Fabrega J Burrel M Garcia-Criado A Kelley RK Galle PR Mazzaferro V Salem R Sangro B Singal AG Vogel A Fuster J Ayuso C Bruix J 刘永凡(摘译) 崔笑(摘译) 耿小平(审校) 2022肝胆外科杂志2022,30,5:80
6前庭性偏头痛:诊断标准——Barany学会及国际头痛学会共识文件显示文摘本文提供了前庭性偏头痛的诊断标准,由Barany学会前庭疾患分类委员会及国际头痛学会(IHS)偏头痛分类分委员会共同制定。分类包括前庭性偏头痛及很可能的前庭性偏头痛。与IHS的常规程序相同,前庭性偏头痛作为一种新分类,将首先出现在第3版国际头痛分类(ICHD-3)的附录中。若积累了进一步的证据,很可能的前庭性偏头痛也许会纳入更晚的ICHD版本中。前庭性偏头痛的诊断建立在反复发作的前庭症状、具有偏头痛病史、前庭症状与偏头痛症状间存在时间上的相关性,并排除其他可导致前庭症状的病因。符合前庭性偏头痛诊断的症状包括不同类型的眩晕及头部活动诱发的头晕伴恶心。症状的严重程度必须为中重度。急性发作的持续时间限于5 min^72 h的时间窗内。华驾略 李焰生 Lempert T Olesen J Furman J Waterston J Seemungal B Carey J Bisdorff A Versino M Evers S Newman-Toker D 2013神经病学与神经康复学杂志2013,10,3:60
7温度对美拉德反应的研究(英文)显示文摘本文报道了反应温度对以d-葡萄糖和l-甘氨酸水溶液模式体系美拉德反应的影响。研究了在不同反应温度(80、100、120℃)和不同反应时间下,体系中糖和氨基酸的降解程度,反应中间体:阿利德诺和有机酸的累积程度,类黑素的形成及pH变化程度。研究结果表明:随着反应温度和反应时间的增加,反应速率加快。吴少雄 M A J S van Boeke S I F S Martins 郭祀远 李琳 2005食品科学2005,26,7:54
8Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F 2005中国神经肿瘤杂志2005,3,3:53
9口服西地那非疗法治疗严重肺动脉高压的效果研究显示文摘Singh TP Rohit M Grover A 菅鑫妍 2006中国处方药2006,,8:49
10STAT6免疫组化染色有助于孤立性纤维性肿瘤的诊断显示文摘孤立性纤维性肿瘤(SFT)发生部位非常广泛,多数为良性,约10%的病例表现为侵袭性。根据组织学特征和CD34表达能够对大多数SYT病例做出准确诊断,但SFT组织学的多样性、偶尔出现意外的免疫表型可能对诊断造成困难。分子分析发现大多数良恶性SFTs均存在特异性NAB2-STAT6融合基因。但基因检测需要专门的设备,花费较高,无法常规应用。Yoshida A Tsuta K Ohno M 李慧明(摘译) 余英豪(审校) 2014临床与实验病理学杂志2014,30,5:41
11弥漫性中线胶质瘤,组蛋白H3-K27M突变型:47例形态学变异谱系及相关遗传学改变分析显示文摘最近发现在儿童和年轻人丘脑、桥脑和脊髓的高级别胶质瘤中存在编码组蛋白H3的亚型H3.3和H3.1的H3F3A和HIST1H3B基因体细胞突变。然而,关于发生这些肿瘤的患者和部位具体范围,以及形态学谱系和相关遗传学改变仍然不确定。本文检测47例伴组蛋白H3-K27M突变的弥漫性中线胶质瘤,包括25例男性和22例女性患者,年龄2~65岁(中位年龄14岁)。肿瘤中心位置除了位于桥脑(17例)、丘脑(15例)和脊髓(9例),还可见于第三脑室(3例)、下丘脑(1例)、松果体区(1例)和小脑(1例)。Solomon D A Wood M D Tihan T 李晓玲 王行富 2016临床与实验病理学杂志2016,32,9:49
12患者肠道微生物群失调与肠上皮屏障功能障碍显示文摘最近的证据表明,在动物模型中,肠道病理学和微生物组与高血压之间存在联系。然而,这种关联在人类中是否存在尚不清楚。因此,该研究的目的是检验高血压患者具有明显特异的肠道微生物组以及肠上皮屏障功能标记物和微生物组组成可以预测收缩压变化的假设。研究者通过鸟枪法宏基因组学分析粪便样本显示微生物分类和功能变化,结果显示高血压患者和对照受试者之间丁酸盐产生存在差异。Kim S Goel R Kumar A Qi Y Lobaton G Hosaka K Mohammed M Handberg EM Richards EM Pepine CJ Raizada MK 刘青 叶鹏 2018中华高血压杂志2018,26,9:45
13Acute-on-chronic liver failure:Pathogenesis,prognostic factors and management显示文摘Acute-on-chronic liver failure(ACLF) is increasingly recognized as a complex syndrome that is reversiblein many cases. It is characterized by an acute deterioration of liver function in the background of a pre-existing chronic liver disease often associated with a high short-term mortality rate. Organ failure(OF) is always associated, and plays a key role in determining the course, and the outcome of the disease. The definition of ACLF remains controversial due to its overall ambiguity, with several disparate criteria among various associations dedicated to the study of liver diseases. Although the precise pathogenesis needs to be clarified, it appears that an altered host response to injury might be a contributing factor caused by immune dysfunction, ultimately leading to a pro-inflammatory status, and eventually to OF. The PIRO concept(Predisposition, Insult, Response and Organ Failure) has been proposed to better approach the underlying mechanisms. It is accepted that ACLF is a different and specific form of liver failure, where a precipitating event is always involved, even though it cannot always be ascertained. According to several studies, infections and active alcoholism often trigger ACLF. Viral hepatitis, gastrointestinal haemorrhage, or drug induced liver injury, which can also provoke the syndrome. This review mainly focuses on the physiopathology and prognostic aspects. We believe these features are essential to further understanding and providing the rationale for improveddisease management strategies.Sara Blasco-Algora José Masegosa-Ataz María Luisa Gutiérrez-García Sonia Alonso-López Conrado M Fernández-Rodríguez 2015World Journal of Gastroenterology2015,21,42:45
14青藏高原东缘晚新生代成都盆地物源分析与水系演化显示文摘成都盆地位于青藏高原东缘,夹于龙门山与龙泉山之间,盆地中充填了3.6M a以来的大邑砾岩、雅安砾石层和晚更新世—全新世砾石层,其物源均来源于盆地西侧的龙门山,具横向水系和单向充填的特征。本次以物源区分析作为切入点,以岷江和青衣江水系为重点,采用砾岩成分分析、砂岩岩屑成分分析、重矿物分析和砾石的地球化学分析等基本方法,开展青藏高原东缘晚新生代以来的古水系重建工作,研究结果表明,成都盆地主要有两个物源区,其中成都盆地北部的都江堰街子场、崇州白塔山、大邑白岩沟、大邑氮肥厂、彭州丁家湾、彭州葛仙山等剖面中的砾石层在碎屑成分、重矿物和花岗岩砾石的地球化学成分等方面相似,应为古岷江的产物,而其与现代岷江在砾岩成分和重矿物特征等方面的差异性则表明古岷江可能存在改道的现象;成都盆地南部的庙坡剖面和熊坡东剖面中的砾石层在碎屑成分、重矿物和花岗岩砾石的地球化学成分等方面相似,应为古青衣江的产物,但其流向却与现代青衣江的流向不同,表明熊坡背斜是在大邑砾岩沉积之后隆起的,它的隆起迫使古青衣江改道。李勇 黎兵 Steffen D DensmoreAL RichardsonNJ 周荣军 Ellis M A 张毅 2006沉积学报2006,24,3:38
15MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells显示文摘Godlewski J Nowicki MO Bronisz A Nuovo G Palatini J De Lay M Van Brocklyn J Ostrowskl MC Chlocca EA Lawler SE. 2010中国神经肿瘤杂志2010,8,1:37
16AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) 2016实用药物与临床2016,19,10:37
17Roux-en-Y versus BillrothⅠreconstruction after distal gastrectomy for gastric cancer:A meta-analysis显示文摘AIM:To conduct a meta-analysis to compare Rouxen-Y(R-Y) gastrojejunostomy with gastroduodenal Billroth Ⅰ(B-Ⅰ) anastomosis after distal gastrectomy(DG) for gastric cancer.METHODS:A literature search was performed to identify studies comparing R-Y with B-Ⅰ after DG for gastric cancer from January 1990 to November 2012 in Medline,Embase,Science Citation Index Expanded and the Cochrane Central Register of Controlled Trials in The Cochrane Library.Pooled odds ratios(OR) or weighted mean differences(WMD) with 95%CI were calculated using either fixed or random effects model.Operative outcomes such as operation time,intraoperative blood loss and postoperative outcomes such as anastomotic leakage and stricture,bile reflux,remnant gastritis,reflux esophagitis,dumping symptoms,delayed gastric emptying and hospital stay were the main outcomes assessed.Meta-analyses were performed using RevMan 5.0 software(Cochrane library).RESULTS:Four randomized controlled trials(RCTs) and 9 non-randomized observational clinical studies(OCS) involving 478 and 1402 patients respectively were included.Meta-analysis of RCTs revealed that R-Y reconstruction was associated with a reduced bile reflux(OR 0.04,95%CI:0.01,0.14;P < 0.00 001) and remnant gastritis(OR 0.43,95%CI:0.28,0.66;P = 0.0001),however needing a longer operation time(WMD 40.02,95%CI:13.93,66.11;P = 0.003).Metaanalysis of OCS also revealed R-Y reconstruction had a lower incidence of bile reflux(OR 0.21,95%CI:0.08,0.54;P = 0.001),remnant gastritis(OR 0.18,95%CI:0.11,0.29;P < 0.00 001) and reflux esophagitis(OR 0.48,95%CI:0.26,0.89;P = 0.02).However,this reconstruction method was found to be associated with a longer operation time(WMD 31.30,95%CI:12.99,49.60;P = 0.0008).CONCLUSION:This systematic review point towards some clinical advantages that are rendered by R-Y compared to B-Ⅰ reconstruction post DG.However there is a need for further adequately powered,welldesigned RCTs comparing the same.Jun-Jie Xiong Kiran Altaf Muhammad A Javed Quentin M Nunes Wei Huang Gang Mai Chun-Lu Tan Rajarshi Mukherjee Robert Sutton Wei-Ming Hu Xu-Bao Liu 2013World Journal of Gastroenterology2013,19,7:33
18龙门山断裂带走滑方向的反转及其沉积与地貌标志显示文摘根据龙门山前陆盆地西缘沉降中心、冲积扇侧向迁移、活动构造地貌和古地磁等标志及龙门山在中生代以来的走滑作用和走滑方向的标定研究,结果表明:龙门山断裂带具有走滑性质,走滑方向曾发生过反转,在反转之前以左行走滑作用为特征,在反转之后以右行走滑作用为特征。根据地层记录和古地磁证据,认为龙门山走滑方向反转的时间应介于43 M a^3.6 M a之间,即由中生代至早新生代时期的左行走滑作用反转为晚新生代时期的右行走滑作用。然对龙门山断裂带走滑方向反转的成因初步分析认为晚新生代龙门山右行走滑作用是印-亚碰撞后构造作用的产物,晚三叠世至早新生代左行走滑作用是青藏高原自晚三叠世以来大陆碰撞作用导致松潘-甘孜褶皱带北东-南西向缩短的产物。李勇 周荣军 A L Densmore M A Ellis 2006矿物岩石2006,26,4:32
19Measurement of circulating levels of VEGF-A,-C,and -D and their receptors,VEGFR-1 and -2 in gastric adenocarcinoma显示文摘AIM: To analyze the serum levels and prognostic significance of vascular endothelial growth factor (VEGF) -A,-C,and -D,and their receptors,VEGFR-1 and -2 in gastric adenocarcinomas. METHODS: The serum levels of VEGF family members were measured in 76 control subjects and 76 patients with gastric adenocarcinoma using an enzyme-linked immunosorbent assay (ELISA). These measurements were correlated with clinco-pathological features and survival rates. RESULTS: The serum levels of VEGF-A and its receptor,VEGFR-1,were signifi cantly higher in patients with gastric cancer than in healthy donors (t = 2.3,P = 0.02 and t = 4.2,P < 0.0001,respectively). In contrast,the serum levels of VEGF-D were signif icantly higher in control subjects than in patients (t = 2.9,P = 0.004). There was no significant difference in serum levels of VEGF-C and VEGFR-2 between patients and controls. VEGF-C was associated with advanced tumor stage and presence of metastasis. VEGFR-1 was associated with metastasis,advanced overall stage,tumor differentiation and survival. VEGFR-2 levels were associated with poor tumor differentiation. There was no significant prognostic value for any of the VEGF family members or their receptors except for VEGFR-1 where high levels were associated with a poor overall survival. CONCLUSION: Serum VEGF levels vary significantly in the same cohort of patients with variable clinico-pathological features and prognostic values. The simultaneous measurement of VEGF receptors levels in sera may overcome the limitations of a single biomarker assay.Mansour S Al-Moundhri A Al-Shukaili M Al-Nabhani B Al-Bahrani IA Burney A Rizivi SS Ganguly 2008World Journal of Gastroenterology2008,14,24:32
20新媒体联盟地平线报告:2017图书馆版显示文摘地平线报告系列展示了5年内创新实践和技术对全球学术与研究型图书馆的影响。报告涉及6大关键趋势,6种重要挑战和6项技术发展,它们影响着图书馆战略、运营和服务,包括学习、创意调查、研究和信息管理。其中专家们认为大数据、数字学术技术、图书馆服务平台、网络身份、人工智能、物联网等技术具有促进学术和研究型图书馆发生真正改变的潜力。本报告为图书馆领导者、图书馆工作人员、政策制定者和技术人员提供参考和技术规划指南。S·亚当斯·贝克尔 M·卡明斯 A·戴维斯 A·弗里曼 C·霍尔·盖辛格 V·安娜塔娜额亚娟 K·兰利 N·沃尔夫森 高茜(译) 曹红岩(译) 徐路(译) 周晖(译) 谢艳秋(译) 洪长勇(译) 王丽媛(译) 鄂丽君(译) 2017开放学习研究2017,22,5:33
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