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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Environment,tourism and land use planning-Riachinho Basin,Brazil显示文摘 | Maria G P Leila N M V Alexandre U | 2001 | Environmental Management and Health2001，12，1： | 1 |
| 3 | 3D reconstruction of cultural heritages:challenges and advances on precise mesh integration显示文摘 | Jurandir de O S J Alexandre V Olga R P B | 2012 | Computer Vision and Image Understanding2012，116，12： | 1 |
| 4 | Hot start PCR with heat-activatable primers: a novel approach for improved PCR performance显示文摘 | Alexandre V Natasha p Joyclyn Y | 2008 | Nucleic Acids Research2008，36，20： | 1 |
| 5 | Dynamic DNA methyla- tion programs persistent adverse effects of early-life stess 显示文摘 | Chris M Alexandre V P Yonghe W | 2009 | Nat Neurosei2009，12，12： | 1 |
| 6 | Crypto- genic organizing pneumonia mimicking malignacy in a pa tient with rheumatoid arthritis显示文摘 | Konsta M Bournia V K Alexandrou P | 2011 | J Rheumatol2011，38，9： | 1 |
| 7 | Improved interfacial mechanical properties of Al2O3-13wt%TiO2plasma sprayed coatingsderived from nanocrystalline powders显示文摘 | Pavitra B Nitin P P Alexandre V | 2003 | Acta Materialia2003，51，29： | 1 |
| 8 | Interference mitigation in a repeater and pseudolite indoor positioning system 显示文摘 | ALEXANDRE V P NEL S | 2009 | IEEE Journal of Selected Topics in Signal Processing2009，3，5： | 1 |
| 9 | Automatic image segmentation by tree pruning 显示文摘 | Felipe P G Bergo Alexandre X Fal cao Paulo A V Miranda | 2007 | Journal of Mathematical Imaging and Vision2007，29，23： | 1 |
| 10 | 3D porosity prediction from seismic inversion and neural networks显示文摘 | Emilson P L ALexandre C V | 2011 | Computers & Geosciences2011，37，8： | 1 |
| 11 | Monitoring immune dysfunctions in the septic patient:a new skin for the old ceremony显示文摘 | Guillaume M Fabienne V Alexandre P | 2008 | I Mol Med2008，14，12： | 1 |
| 12 | The interface between titanium and carbon nanotubes显示文摘 | ALEXANDRE F IRENE S M XIAOXING K GUSTAAF V T JACQUES G JEAN J P WOLGANG D CARLA B CHRISTOPHER P | 2009 | A European Journal of Chemical Physics and Physical Chemistry2009，10，： | 1 |
| 13 | Test selection based on communicating nondeterministic finite-state machines using a generalized WP-method 显示文摘 | Luo G Bochmann G V Alexandre P | 1994 | IEEE Trans on Software Engineering1994，20，2： | 1 |
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