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| 1 | Metastatic type 1 gastric carcinoid:A real threat or just a myth?显示文摘AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1(GCA1).METHODS:Information on clinical,biochemical,radiological,histopathological findings,the extent of the disease,as well as the use of different therapeutic modalities and the long-term outcome were recorded.Patients’data were assessed at presentation,and thereafter at 6 to 12 monthly intervals both clinically and biochemically,but also endoscopically and histopathologically.Patients were evaluated for the presence of specific symptoms;the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also recorded.The evaluation of response to treatment was defined using established WHO criteria.RESULTS:We studied twenty consecutive patients with a mean age of 55.1 years.The mean follow-up period was 83 mo.Twelve patients had regional lymph node metastases and 8 patients had liver metastases.The primary tumor mean diameter was 20.13±10.83mm(mean±SD).The mean Ki-67 index was 6.8%±11.2%.All but one patient underwent endoscopic or surgical excision of the tumor.The disease was stable in all but 3 patients who had progressive liver disease.All patients remained alive during the follow-up period.CONCLUSION:Metastatic GCA1 carries a good overall prognosis,being related to a tumor size of≥1 cm,an elevated Ki-67 index and high serum gastrin levels. | Simona Grozinsky-Glasberg Dimitrios Thomas Jonathan R Strosberg Ulrich-Frank Pape Stephan Felder Apostolos V Tsolakis Krystallenia I Alexandraki Merav Fraenkel Leonard Saiegh Petachia Reissman Gregory Kaltsas David J Gross | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 2 | Small bowel ulcerative lesions are common in elderly NSAIDs users with peptic ulcer bleeding显示文摘AIM: To determine the frequency of small bowel ulcerative lesions in patients with peptic ulcer and define the significance of those lesions. METHODS: In our prospective study, 60 consecutive elderly patients with upper gastrointestinal bleeding from a peptic ulceration(cases) and 60 matched patients with a non-bleeding peptic ulcer(controls) underwent small bowel capsule endoscopy, after a negative colonoscopy(compulsory in our institution). Controls were evaluated for non-bleeding indications. Known or suspected chronic inflammatory conditions and medication that could harm the gut were excluded. During capsule endoscopy, small bowel ulcerative lesions were counted thoroughly and classified according to Graham classification. Other small bowellesions were also recorded. Peptic ulcer bleeding was controlled endoscopically, when adequate, proton pump inhibitors were started in both cases and controls, and Helicobacter pylori eradicated whenever present. Both cases and controls were followed up for a year. In case of bleeding recurrence upper gastrointestinal endoscopy was repeated and whenever it remained unexplained it was followed by repeat colonoscopy and capsule endoscopy.RESULTS: Forty(67%) cases and 18(30%) controls presented small bowel erosions(P = 0.0001), while 22(37%) cases and 4(8%) controls presented small bowel ulcers(P < 0.0001). Among non-steroidal antiinflammatory drug(NSAID) consumers, 39(95%) cases and 17(33%) controls presented small bowel erosions(P < 0.0001), while 22(55%) cases and 4(10%) controls presented small bowel ulcers(P < 0.0001). Small bowel ulcerative lesions were infrequent among patients not consuming NSAIDs. Mean entry hemoglobin was 9.3(SD = 1.4) g/d L in cases with small bowel ulcerative lesions and 10.5(SD = 1.3) g/dL in those without(P = 0.002). Cases with small bowel ulcers necessitate more units of packed red blood cells. During their hospitalization, 6(27%) cases with small bowel ulcers presented bleeding recurrence most possibly attributed to small bowel ulcers, nevertheless 30-d mortality was zero. Presence of chronic obstructive lung disease and diabetes was related with unexplained recurrence of hemorrhage in logistic regression analysis, while absence of small bowel ulcers was protective(relative risk 0.13, P = 0.05).CONCLUSION: Among NSAID consumers, more bleeders than non-bleeders with peptic ulcers present small bowel ulcers; lesions related to more severe bleeding and unexplained episodes of bleeding recurrence. | Panagiotis Tsibouris Chissostomos Kalantzis Periklis Apostolopoulos Antonios Zalonis Peter Edward Thomas Isaacs Mark Hendrickse Georgios Alexandrakis | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，12： | 6 |
| 3 | Evaluation of capsule endoscopy in active, mild-to-moderate, overt, obscure GI bleeding <ce:link locator='fx1'/>显示文摘 | Periklis Apostolopoulos Christos Liatsos Ian M. Gralnek Chrissostomos Kalantzis Eleftheria Giannakoulopoulou Georgios Alexandrakis Panagiotis Tsibouris Evagelos Kalafatis Nikolaos Kalantzis | 2007 | Gastrointestinal Endoscopy2007，，6： | 3 |
| 4 | The clinical and prognostic significance of erythrocyte sedimentation rate(ESR),serum interleukin-6 (IL-6) and acute phase protein levels in multiple myeloma显示文摘 | Alexandrakis MG Passam FH Ganotakis ES | 2003 | Clin Lab Haematol2003，25，1： | 1 |
| 5 | The clinical significance of serum and bronchoalveolar lavage inflammatory cytokines in patients at risk for acute respiratory distress syndrome 显示文摘 | Bouros D Alexandrakis MG Antoniou KM | 2004 | BMC Pulm Med2004，4，： | 1 |
| 6 | Pleural effusions in hematologic malignancies 显示文摘 | Alexandrakis MG Passam FH Kyriakou DS | 2004 | Chest2004，125，4： | 1 |
| 7 | Theclinical and prognostic significance of erythrocyte sedimentationrate(ESR),serum interleukin-6(IL-6)and acute phaseprotein levels in multiple myeloma显示文摘 | Alexandrakis MG Passam FH Ganotakis ES | 2003 | Clin Lab Haematol2003，25，1： | 1 |
| 8 | Indices of low-grade chronic inflammation in polyeystic ovary syndrome and the beneficial effect of mefformin显示文摘 | Diamanti-Kandarakis E Paterakis T Alexandraki K | 2006 | Hum Reprod2006，21，6： | 1 |
| 9 | Serum interleukin-17 and its relationship to angiogenic factors in multiple myeloma显示文摘 | Alexandrakis MG Pappa CA Miyakis S | 2006 | Eur J Intern Med2006，17，6： | 1 |
| 10 | Inflammatory process in type 2 diabetes:the role of cytokines显示文摘 | Alexandraki K Piperi C Kalofoutis C | 2006 | Ann NY Acad Sci2006，1084，： | 1 |
| 11 | Relationship between circulating serum soluble interleukin-6 receptor and the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in multiple myeloma显示文摘 | Alexandrakis MG Passam FH Boula A | 2003 | Ann Hematol2003，82，1： | 1 |
| 12 | Serum proinflammatory cytokines and its relationship to clinical parameters in lung cancer patients with reactive thrombocytosis显示文摘 | Alexandrakis MG Passam FH Perisinakis K | 2002 | Respir Med2002，96，8： | 1 |
| 13 | Pleuraleffusions in hematologic malignancies 显示文摘 | Alexandrakis MG Passam FH Kyriakou I)S el al | 2004 | Chest2004，125，： | 1 |
| 14 | Different angiogenie activity in pulmonary sarcoidosis and idiopathic pulmonary fibrosis显示文摘 | Antoniou KM Tzouvelekis A Alexandrakis MG | 2006 | Chest2006，130，： | 1 |
| 15 | Association between increased levels of IL-2 and IL-15 and outcome in patients with early acute respiratory distress syndrome 显示文摘 | Agouridakis P Kyriakou D Alexandrakis MG | 2002 | Eur J Clin Invest2002，32，11： | 1 |
| 16 | Rela-tionship between serum levels of vascular endothelialgrowth factor,hepatocyte growth factor and matrixmetalloproteinase-9 with biochemical markers of bonedisease in multiple myeloma显示文摘 | Alexandrakis MG Sfiridaki A Miyakis S | 2007 | Clin Chim Acta2007，379，2： | 1 |
| 17 | Serum evaluation of angiogenic cytokine basic fibroblast growth factor, hepatocyte growth factor and TNF-alpha in patients with myelodysplastic syndromes: correlation with hone marrow microvascular density 显示文摘 | Alexandrakis MG Passam FH Pappa CA | 2005 | Int J Immunopathol Pharmacol2005，18，2： | 1 |
| 18 | Combined pars plana vitrectomy and glaucoma drainage implant placement for refractory glaucoma显示文摘 | Scott IU Alexandrakis G Flynn HW Jr | 2000 | Am J Ophthamol2000，129，： | 1 |
| 19 | Recurent orbital solitary fibrous tumor in a 14-year-old girl显示文摘 | Alexandrakis G Johnson TE | 2000 | Am J Ophthalmol2000，130，3： | 1 |
| 20 | Thl cytokine pattern (IL-12 and IL-18) in bronchoalveolar lavage fluid (BALF) be- fore and after treatment with interferon gamma-lb (IFN--lb) or eolchi-eine in patient with idiopathic pulmonary fibrosis (IPF/ UIP) 显示文摘 | Antoniou KM Alexandrakis MG Sfiridaki K | 2004 | Sarcoidosis Vasc Diffuse Lung Dis2004，21，2： | 1 |
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