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| 1 | Factors affecting breastfeeding duration in Greece:What is important?显示文摘AIM:To investigate factors associated with breastfeeding duration(BD) in a sample of mothers living in Greece.METHODS:Four hundred and twenty-eight mothers(438 infants) were initially recruited in a tertiary University Hospital.Monthly telephone interviews(1665in total) using a structured questionnaire(one for each infant) were conducted until the sixth postpartum month.Cox regression analysis was used to assess factors influencing any BD.RESULTS:Any breastfeeding rates in the first,third,and sixth month of the infant's life reached 87.5%,57.0%and 38.75%,respectively.In the multivariate analysis,maternal smoking in the lactation period[hazard-ratio(HR) = 4.20]and psychological status(HR = 1.72),and the introduction of a pacifier(HR =2.08),were inversely associated,while higher maternal education(HR_(university/college vs primary/high school) = 0.53,HR_(master's vs primary/high school) = 0.20),and being an immigrant(HR = 0.35) were positively associated with BD.CONCLUSION:Public health interventions should focus on campaigns against smoking during lactation,target women of lower educational status,and endorse the delayed introduction of pacifiers. | Evangelia-Filothei Tavoulari Vassiliki Benetou Petros V Vlastarakos Theodora Psaltopoulou George Chrousos George Kreatsas Alexandras Gryparis Athena Linos | 2016 | World Journal of Clinical Pediatrics2016，5，3： | 12 |
| 2 | Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma显示文摘AIM To analyze colorectal carcinogenesis and age-related DNA methylation alterations of gene sequences associated with epigenetic clock CpG sites. METHODS In silico DNA methylation analysis of 353 epigenetic clock Cp G sites published by Steve Horvath was performed using methylation array data for a set of 123 colonic tissue samples [64 colorectal cancer(CRC), 42 adenoma, 17 normal; GEO accession number: GSE48684]. Among the differentially methylated agerelated genes, secreted frizzled related protein 1(SFRP1) promoter methylation was further investigated in colonic tissue from 8 healthy adults, 19 normal children, 20 adenoma and 8 CRC patients using bisulfite-specific PCR followed by methylation-specific high resolution melting(MS-HRM) analysis. m RNA expression of age-related 'epigenetic clock' genes was studied using Affymetrix HGU133 Plus2.0 whole transcriptome data of 153 colonic biopsy samples(49 healthy adult, 49 adenoma, 49 CRC, 6 healthy children)(GEO accession numbers: GSE37364, GSE10714, GSE4183, GSE37267). Whole promoter methylation analysis of genes showing inverse DNA methylationgene expression data was performed on 30 colonic samples using methyl capture sequencing.RESULTS Fifty-seven age-related Cp G sites including hypermethylated PPP1R16 B, SFRP1, SYNE1 and hypomethylated MGP, PIPOX were differentially methylated between CRC and normal tissues(P < 0.05, ?β≥ 10%). In the adenoma vs normal comparison, 70 CpG sites differed significantly, including hypermethylated DKK3, SDC2, SFRP1, SYNE1 and hypomethylated CEMIP, SPATA18(P < 0.05, ?β≥ 10%). In MS-HRM analysis, the SFRP1 promoter region was significantly hypermethylated in CRC(55.0% ± 8.4 %) and adenoma tissue samples(49.9% ± 18.1%) compared to normal adult(5.2% ± 2.7%) and young(2.2% ± 0.7%) colonic tissue(P < 0.0001). DNA methylation of SFRP1 promoter was slightly, but significantly increased in healthy adults compared to normal young samples(P < 0.02). This correlated with significantly increased SFRP1 m RNA levels in children compared to normal adult samples(P < 0.05). In CRC tissue the mR NA expression of 117 agerelated genes were changed, while in adenoma samples 102 genes showed differential expression compared with normal colonic tissue(P < 0.05, logF C > 0.5). The change of expression for several genes including SYNE1, CLEC3 B, LTBP3 and SFRP1, followed the same pattern in aging and carcinogenesis, though not for all genes(e.g., MGP). CONCLUSION Several age-related DNA methylation alterations can be observed during CRC development and progression affecting the m RNA expression of certain CRC- and adenoma-related key control genes. | Orsolya Galamb Alexandra Kalmár Barbara Kinga Barták árpád V Patai Katalin Leiszter Bálint Péterfia Barnabás Wichmann Gábor Valcz Gábor Veres Zsolt Tulassay Béla Molnár | 2016 | World Journal of Gastroenterology2016，22，47： | 7 |
| 3 | Current progress in the treatment of chronic hepatitis C显示文摘Over the last decade,the standard of care for the treatment of chronic hepatitis C has been the combination of pegylated-interferon-alfa(PEG-IFN) and ribavirin(RBV) which results in sustained virological response(SVR) rates of 75%-85% in patients with genotypes 2 or 3 but only of 40%-50% in patients with genotype 1.Currently,there are rapid and continuous developments of numerous new agents against hepatitis C virus(HCV),which are the focus of this review.Boceprevir and telaprevir,two first-generation NS3/4A HCV protease inhibitors,have been recently licensed in several countries around the world to be used in combination with PEGIFN and RBV for the treatment of genotype 1 patients.Boceprevir or telaprevir based triple regimens,compared with the PEG-IFN/RBV combination,improve the SVR rates by 25%-31% in treatment-na ve genotype 1 patients,by 40%-64% in prior relapsers,by 33%-45% in prior partial responders and by 24%-28% in prior null responders.At the same time,the application of response-guided treatment algorithms according to the on-treatment virological response results in shortening of the total therapy duration to only 24 wk in 45%-55% of treatment-na ve patients.There are,however,several challenges with the use of the new triple combinations in genotype 1 patients,such as the need for immediate results of HCV RNA testing using sensitive quantitative assays,new and more frequent adverse events(anemia and dysgeusia for boceprevir;pruritus,rash and anemia for telaprevir),new drug interactions and increasing difficulties in compliance.Moreover,the SVR rates are still poor in very difficult to treat subgroups of genotype 1 patients,such as null responders with cirrhosis,while there is no benefit for patients who cannot tolerate PEGIFN/RBV or who are infected with non-1 HCV genotype.Many newer anti-HCV agents of different classes and numerous combinations are currently under evaluation with encouraging results.Preliminary data suggest that the treatment of chronic HCV patients with well tolerated combinations of oral agents without PEG-IFN is feasible and may lead to a universal HCV cure over the next 5-10 years. | Alexandra Alexopoulou George V Papatheodoridis | 2012 | World Journal of Gastroenterology2012，18，42： | 6 |
| 4 | Aquaculture potential of the common octopus (Octopus vulgaris Cuvier, 1797): a review显示文摘 | Paulo V P Pedro S Alexandra B | 2004 | Aquaculture2004，238，： | 1 |
| 5 | Late Glacial temperature and precipitation changes in tile lowland Neotropics by tandem measurement of lSO in biogenic carbonate and gypsum hydration water显示文摘 | DAVID A H ALEXANDRA V T CAMILLA J W | 2012 | Geochimica et Cosmochimica Acta2012，77，： | 1 |
| 6 | Clinical end points in coronary stent trials:a case for standardized definitions显示文摘 | Serruys V Eugene M Alexandra L | | 0，，17： | 1 |
| 7 | Elevation of intracellular calcium levels contributes to the inhibition of nitric oxide production by artial natriuretic peptide 显示文摘 | ALEXANDRA K K ANGELIKA M V | 2001 | Immunology and Cell Biology2001，79，： | 1 |
| 8 | Redundancy of myostatin and growth/differentiation factor 11function显示文摘 | Alexandra C Mcpherron Thanh V Huynh Se - Jln Lee | 2009 | BMC2009，，： | 1 |
| 9 | Chemical routes for the transformation of biomass into chemicals 显示文摘 | Avelino C Sara I Alexandra V | 2007 | Chem Rev2007，107，6： | 1 |
| 10 | Chemical routes for the transformation of biomass into chemicals 显示文摘 | AVELINO C SARA I ALEXANDRA V | 2007 | ChemRev2007，46，38： | 1 |
| 11 | Advantages of enteral nutrition over parenteral nutrition显示文摘 | David S S Monika V Alexandra G | 2013 | Therap Adv Gastroenterol2013，6，2： | 1 |
| 12 | Chemical routes for the transformation of biomass into chemicals显示文摘 | Avelino C Sara I Alexandra V | 2007 | Chem Rev2007，107，： | 1 |
| 13 | Evolution of plant-like crystalline storage polysaccharide in the protozoan parasite Toxoplasma gondii argues for a red alga ancestry 显示文摘 | Alexandra C Jean-Stephane V Luc L | 2005 | Molecular Evolution2005，60，： | 1 |
| 14 | Pilot plant tests on phosphate removal proeess显示文摘 | Glbert V Levin George J Topol Alexandra G Tarnay | 1972 | Journal WPCF1972，44，10： | 1 |
| 15 | Overgrowth of bacteria implicated in IBS显示文摘 | Cathel K Alexandra V | 2001 | Trends in Microbiology2001，9，2： | 1 |
| 16 | Assessment of the load and transcriptional dynamics of Chlamydia trachomatis plasmid according to strains’ tissue tropism显示文摘 | Rita Ferreira Vítor Borges Alexandra Nunes Maria José Borrego Jo?o Paulo Gomes | 2013 | Microbiological Research2013，，6： | 1 |
| 17 | Chemical routes for the transformation of biomass into chemicals显示文摘 | Avelino C Sara I Alexandra V | 2007 | Chem Rev2007，107，： | 1 |
| 18 | Purification, characterization and activities of two hemolytic and antibacterial proteins from coelomic fluid of the annelid Eisenia fetida andrei显示文摘 | ALEXANDRA M MARGUERITE L PIERRE V | 1997 | Biochimica et Biophysica Acta1997，1337，： | 1 |
| 19 | Molecular breeding of polymerases for amplification of ancient DNA显示文摘 | Marcd A Michael H Alexandra V | 2007 | Nat Biotechnol2007，25，： | 1 |
| 20 | Preparation and characterization of glycerol-based cleavable surfactants and derived vesicles 显示文摘 | Maria J C Avelino C Alexandra V | 1989 | J Am Chem Soc1989，111，： | 1 |
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