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您的检索式：作者名="Alexandra Babanova"
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| 1 | Patients with functional bowel disorder have disaccharidase deficiency:A single-center study from Russia显示文摘BACKGROUND Functional bowel disorder(FBD)may be caused by a decrease in disaccharidase activity.Thus,the timely diagnosis of disaccharidase deficiency could lead to a better prognosis in patients with this condition.AIM To determine the potential value of intestinal disaccharidases glucoamylase,maltase,sucrase,and lactase in understanding the etiology and pathogenesis of FBD.METHODS A total of 82 FBD patients were examined.According to the Rome IV criteria(2016),23 patients had diarrhea-predominant irritable bowel syndrome(IBS),33 had functional diarrhea,10 had constipation-predominant IBS,4 had functional constipation,and 12 had mixed IBS.The Dahlqvist method was used to measure disaccharidase activity in the brush-border membrane of mature enterocytes of the small intestine,in duodenal biopsies obtained during esophagogastroduodenoscopy.RESULTS Lactase deficiency was detected in 86.5%of patients,maltase deficiency in 48.7%,sucrase deficiency in 50%,and glucoamylase deficiency in 84.1%.The activities of all enzymes were reduced in 31.7%of patients,and carbohydrase deficiency was detected in 63.5%of patients.The low activity of enzymes involved in membrane digestion in the small intestine was found in 95.2%of patients.CONCLUSION In 78 of the 82 patients with FBD,gastrointestinal symptoms were associated with disaccharidase deficiency. | Saria Dbar Olga Akhmadullina Elena Sabelnikova Nikolai Belostotskiy Asfold Parfenov Svetlana Bykova Sergey Bakharev Elena Baulo Alexandra Babanova Lilia Indeykina Tatyana Kuzmina Tatiana Kosacheva Aleksey Spasenov Alina Makarova | 2021 | World Journal of Clinical Cases2021，9，17： | 1 |
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