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| 1 | Malignant biliary obstruction:From palliation to treatment显示文摘Malignant obstruction of the bile duct from cholan-giocarcinoma,pancreatic adenocarcinoma,or other tumors is a common problem which may cause debilitating symptoms and increase the risk of subsequent surgery.The optimal treatment-including the decision whether to treat prior to resection-depends on the type of malignancy,as well as the stage of disease.Preoperative biliary drainage is generally discouraged due to the risk of infectious complications,though some situations may benefit.Patients who require neoadjuvant therapy will require decompression for the prolonged period until attempted surgical cure.For pancreatic cancer patients,self-expanding metallic stents are superior to plastic stents for achieving lasting decompression without stent occlusion.For cholangiocarcinoma patients,treatment with percutaneous methods or nasobiliary drainage may be superior to endoscopic stent placement,with less risk of infectious complications or failure.For patients of either malignancy who have advanced disease with palliative goals only,the choice of stent for endoscopic decompression depends on estimated survival,with plastic stents favored for survival of < 4 mo.New endoscopic techniques may actually extend stent patency and patient survival for these patients by achieving local control of the obstructing tumor.Both photodynamic therapy and radiofrequency ablation may play a role in extending survival of patients with malignant biliary obstruction. | Brian R Boulay Aleksandr Birg | 2016 | World Journal of Gastrointestinal Oncology2016，8，6： | 24 |
| 2 | 基于硫酸为电解液的超级电容器木基活性炭电极材料的制备(英文)显示文摘以NaOH为活化剂,采用两步热化学过程制备出木基活性炭。将所制活性炭用作以硫酸为电解液的超级电容器电极材料。探讨了合成条件对活性炭孔结构和电化学性能。结果表明,在微孔中形成双电层电容,介孔和大孔则实现离子运输。在高的活化温度或高碱炭比下,材料被过度活化,导致高的介孔、大孔孔容,这增加了电解液的吸收,从而降低质量比电容。最佳的活性炭合成条件为,活化温度:600℃,碱炭比:1.25。 | Aleksandrs Volperts Galina Dobele Aivars Zhurinsh Darya Vervikishko Evgeny Shkolnikov Jurijs Ozolinsh | 2017 | 新型炭材料2017，32，4： | 11 |
| 3 | Generalized equation for calculating rock cutting efficiency by pulsed water jets显示文摘One of the promising methods for rock cutting technology is the use of high-speed water jets.In order to improve the cutting capacity of water jets without increasing the hydraulic power of equipment,pulsed water jets are basically used to increase the rock cutting efficiency.However,there are no mature recommendations for selection of rational parameters,and the relationship between indicators of rock cutting efficiency and parameters of pulsed water jet is still not established.In this context,we aimed at developing a generalized equation for calculating rock cutting efficiency,in which all the major parameters in consideration of rock cutting process are included.Then,a calibration of the rational parameters of rock cutting by pulsed water jets was conducted.The results are likely helpful for increasing productivity and reducing energy consumption. | Andrey Polyakov Aleksandr Zhabin Eugene Averin Aleksey Polyakov | 2019 | Journal of Rock Mechanics and Geotechnical Engineering2019，11，4： | 6 |
| 4 | Choice of conodont Idiognathodus simulator (sensu stricto) as the event marker for the base of the global Gzhelian Stage (Upper Pennsylvanian Series, Carboniferous System)显示文摘 | Philip H. Heckel Aleksandr S. Alekseev James E. Barrick Darwin R. Boardman Natalya V. Goreva Tatiana N. Isakova Tamara I. Nemyrovska Katsumi Ueno Elisa Villa David M. Work | 2008 | Episodes2008，31，3： | 5 |
| 5 | Coronary revascularization in the elderly with stable angina显示文摘一个比例与冠的动脉疾病老很快正在成长。因此,他们有更多的严重冠的动脉疾病从 revascularization 导出更多的利益并且为它有更大的需要。老是一个异构的组,但是与更年轻的队相比,最佳的 revascularization 方法的选择在他们之中是更复杂的。在最近的十年,结果在外科和经皮的冠的干预(一种总线标准) 两个都戏剧性地改善了,甚至在很老的人。尽管有证据在的缺乏老,它是明显的,那根冠的动脉绕过外科(CABG ) 在更多的击的价格在长期的幸存上有更显著的效果,当一种总线标准当然是不太侵略的时。年龄本身不是为处理策略的选择的一个标准,但是老对生活和个人独立的质量经常更感兴趣而不是长寿。这件物品讨论影响 revascularization 方法的选择在的因素与稳定的咽峡炎和礼品老为做单个风险利益侧面的一个复杂算法。作为后果,在老病人的 CABG 和一种总线标准的特征被暴露。强调在脆弱和非医学的因素上被集中,包括 psychosocial,作为在做什么选择的策略的决定的必要部件。与病人的好通讯并且给他们不偏的信息被鼓励。 | Kirill Lenarovich Kozlov Aleksandr Andreevich Bogachev | 2015 | Journal of Geriatric Cardiology2015，12，5： | 5 |
| 6 | Nanoscale inhibition of polymorphic and ambidextrous lAPP amyloid aggregation with small molecules显示文摘 | Aleksandr Kakinen Jozef Adamcik Bo Wang Xinwei Ge Raffaele Mezzenga Thomas P. Davis Feng Ding Pu Chun Ke | 2018 | Nano Research2018，11，7： | 4 |
| 7 | 俄罗斯核能供热技术发展与现状分析显示文摘简要介绍了前苏联及俄罗斯的核能供热发展历程,划分为五个较明显的发展阶段。给出目前俄罗斯主要核能供热关键技术,包括前苏联AST-500反应堆的低温核能供热厂、核电站汽轮机抽汽供热以及目前世界先进的漂浮式核能热电站。分析了俄罗斯核电站供热的主要数据,说明俄罗斯目前核能供热的主要技术是核电站供热;给出了俄罗斯未来几年核能供热战略政策,指出俄罗斯与中国核能供热发展的相互积极作用。 | Solomykov Aleksandr 赵金玲 | 2019 | 区域供热2019，，5： | 4 |
| 8 | Galectin-3-centered paracrine network mediates cardiac inflammation and fibrosis upon β-adrenergic insult显示文摘Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been fully illustrated.The present study aimed to determine the mechanisms of cardiac inflammatory amplification following acute sympathetic activation.With bioinformatics analysis,galectin-3 was identified as a potential key downstream effector of β-AR and IL-18 activation.The serum level of galectin-3 was positively correlated with norepinephrine or IL-18 in patients with chest pain.In the heart of mice treated with β-AR agonist isoproterenol (ISO,5 mg kg^(-1)),galectin-3 expression was upregulated markedly later than IL-18 activation,and Nlrp3^(-/-)and Il18^(-/-)mice did not show ISO-induced galectin-3 upregulation.It was further revealed that cardiomyocyte-derived IL-18 induced galectin-3 expression in macrophages following ISO treatment.Moreover,galectin-3deficiency suppressed ISO-induced cardiac inflammation and fibrosis without blocking ISO-induced IL-18 increase.Treatment with a galectin-3 inhibitor,but not a β-blocker,one day after ISO treatment effectively attenuated cardiac inflammation and injury.In conclusion,galectin-3 is upregulated to exaggerate cardiac inflammation and injury following acute β-AR activation,a galectin-3 inhibitor effectively blocks cardiac injury one day after β-AR insult. | Guomin Hu Jimin Wu Huijun Gu Xiangning Deng Wenli Xu Shan Feng Shuaixing Wang Yao Song Zhengda Pang Xiuling Deng Aleksandr E.Vendrov Nageswara R.Madamanchi Marschall S.Runge Xinyu Wang Youyi Zhang Han Xiao Erdan Dong | 2023 | Science China(Life Sciences)2023，66，5： | 3 |
| 9 | Functionality of a bicistronic construction containing HEXA and HEXB genes encoding β-hexosaminidase A for cell-mediated therapy of GM2 gangliosidoses显示文摘Tay-Sachs disease and Sandhoff disease are severe hereditary neurodegenerative disorders caused by a deficiency ofβ-hexosaminidase A(HexA)enzyme,which results in the accumulation of GM2 gangliosides in the nervous system cells.In this work,we analyzed the efficacy and safety of cell-mediated gene therapy for Sandhoff disease and Sandhoff disease using a bicistronic lentiviral vector encoding cDNA of HexAα-andβ-subunit genes separated by the nucleotide sequence of a P2A peptide(HEXA-HEXB).The functionality of the bicistronic construct containing the HEXA-HEXB genetic cassette was analyzed in a culture of HEK293T cells and human umbilical cord blood mononuclear cells(hUCBMCs).Our results showed that the enzymatic activity of HexA in the conditioned medium harvested from genetically modified HEK293T-HEXA-HEXB and hUCBMCs-HEXA-HEXB was increased by 23 and 8 times,respectively,compared with the conditioned medium of native cells.Western blot analysis showed that hUCBMCs-HEXA-HEXB secreted both completely separated HEXA and HEXB proteins,and an uncleaved protein containing HEXA+HEXB linked by the P2A peptide.Intravenous injection of genetically modified hUCBMCs-HEXA-HEXB to laboratory Wistar rats was carried out,and the HexA enzymatic activity in the blood plasma of experimental animals,as well as the number of live cells of immune system organs(spleen,thymus,bone marrow,lymph nodes)were determined.A significant increase in the enzymatic activity of HexA in the blood plasma of laboratory rats on days 6 and 9(by 2.5 and 3 times,respectively)after the administration of hUCBMCsHEXA-HEXB was shown.At the same time,the number of live cells in the studied organs remained unchanged.Thus,the functionality of the bicistronic genetic construct encoding cDNA of the HEXA and HEXB genes separated by the nucleotide sequence of the P2A peptide was shown in vitro and in vivo.We hypothesize that due to the natural ability of hUCBMCs to overcome biological barriers,such a strategy can restore the activity of the missing enzyme in the central nervous system of patients with GM2 gangliosidoses.Based on the obtained data,it can be concluded that intravenous administration of hUCBMCs with HexA overexpression is a promising method of the therapy for GM2 gangliosidoses.The animal protocol was approved by the Animal Ethics Committee of the Kazan Federal University(No.23)on June 30,2020. | Alisa A.Shaimardanova Daria S.Chulpanova Valeriya V.Solovyeva Aleksandr M.Aimaletdinov Albert A.Rizvanov | 2022 | Neural Regeneration Research2022，17，1： | 3 |
| 10 | 丛式井平台设计及井丛分组优化显示文摘改进并测试了包含30多个钻井工程参数的技术-经济模型,通过新开发的计算机程序列出平台上的井丛分组方式并计算其技术经济效益。针对含24口初始产油量不同的井的平台,研究分析了7种钻井方案,得出了3种折现率和5种产油量递减率条件下净现值(NPV)最优的分组方式。研究表明,针对井丛井数不等的井平台,可能只需对现有设计进行轻微调整(改变几个井丛的布局)就能得到最大净现值;相对净现值增幅与净现值的绝对值成反比;相比常规项目中具有相等井数的井丛,采用井丛井数不等的分组方式可以使NPV增幅达到1%,页岩地层开发项目NPV增幅可达2%或更多,边际油田项目增幅高达45%。 | ABRAMOV Aleksandr | 2019 | 石油勘探与开发2019，46，3： | 3 |
| 11 | Endoscopic suturing closure of large mucosal defects after endoscopic submucosal dissection is technically feasible, fast, and eliminates the need for hospitalization (with videos)显示文摘 | Sergey V. Kantsevoy Marianne Bitner Aleksandr A. Mitrakov Paul J. Thuluvath | 2013 | Gastrointestinal Endoscopy2013，，： | 3 |
| 12 | 俄罗斯食用菌产业的现状与发展趋势显示文摘1食用菌的食用历史与中国一样,食用菌是俄罗斯非常传统的食物。大约在10世纪的时候,食用菌在俄罗斯变得非常流行。根据宗教的法规,人们每年应有200天保持斋戒,不能食荤。复活节前的斋戒时间最长,而且很严格,在这一段时间,包括鱼等海产品在内的荤腥食物是不能食用的。 | Aleksandr Khrenov | 2016 | 食药用菌2016，24，1： | 2 |
| 13 | Impact and Friction Sensitivity of Energetic Materials:Methodical Evaluation of Technological Safety Features显示文摘Key methods developed and used in the USSR and in the Russian Federation to determine the impact and friction sensitivity of energetic materials and explosives have been discussed.Experimental methodologies and instruments that underlie the assessment of their production and handling safety have been described.Studies of a large number of compounds have revealed relationships between their sensitivity parameters and structure of individual compounds and compositions.The range of change of physical and chemical characteristics for the compounds we examined covers the entire region of their existence.Theoretical methodology and equations have been formulated to estimate the impact and friction sensitivity parameters of energetic materials and to evaluate the technological safety in use.The developed methodology is characterized by high-accuracy calculations and prediction of sensitivity parameters. | Aleksandr Smirnov Oleg Voronko Boris Korsunsky Tatyana Pivina | 2015 | 火炸药学报2015，38，3： | 2 |
| 14 | Graphene quantum dots rescue protein dysregulation of pancreatic β-cells exposed to human islet amyloid polypeptide显示文摘The amyloid aggregation of peptides and proteins is a hallmark of neurological disorders and type 2 diabetes.Human islet amyloid polypeptide(IAPP),co-secreted with insulin by pancreaticβ-cells,plays dual roles in both glycemic control and the pathology of type 2 diabetes.While IAPP can activate the NLRP3 inflammasome and modulate cellular autophagy,apoptosis and extracellular matrix metabolism,no data is available concerning intracellular protein expression upon exposure to the polypeptide.More surprisingly,how intracellular protein expression is modulated by nanoparticle inhibitors of protein aggregation remains entirely unknown.In this study,we first examined the changing proteomes ofβTC6,a pancreaticβ-cell line,upon exposure to monomeric,oligomeric and fibrillar IAPP,and detailed cellular protein expression rescued by graphene quantum dots(GQDs),an IAPP inhibitor.We found that 29 proteins were significantly dysregulated by the IAPP species,while majority of these proteins were nucleotide-binding proteins.Collectively,our liquid chromatography tandem-mass spectrometry,fluorescence quenching,helium ion microscopy,cytotoxicity and discreet molecular dynamics simulations data revealed a remarkable capacity of GQDs in regulating aberrant protein expression through H-bonding and hydrophobic interactions,pointing to nanomedicine as a new frontier against human amyloid diseases. | Ava Faridi Yunxiang Sun Monika Mortimer Ritchlynn R.Aranha Aparna Nandakumar Yuhuan Li Ibrahim Javed Aleksandr Kakinen Qingqing Fan Anthony W.Purcell Thomas P.Davis Feng Ding Pouya Faridi Pu Chun Ke | 2019 | Nano Research2019，12，11： | 2 |
| 15 | Tailoring the LiNbO_(3)coating of Ni-rich cathode materials for stable and high-performance all-solid-state batteries显示文摘The research and development of advanced nanocoatings for high-capacity cathode materials is currently a hot topic in the field of solid-state batteries(SSBs).Protective surface coatings prevent direct contact between the cathode material and solid electrolyte,thereby inhibiting detrimental interfacial decomposition reactions.This is particularly important when using lithium thiophosphate superionic solid electrolytes,as these materials exhibit a narrow electrochemical stability window,and therefore,are prone to degradation during battery operation.Herein we show that the cycling performance of LiNbO_(3)-coated Ni-rich LiNi_(x)Co_(y)Mn_(z)O_(2)cathode materials is strongly dependent on the sample history and(coating)synthesis conditions.We demonstrate that post-treatment in a pure oxygen atmosphere at 350℃results in the formation of a surface layer with a unique microstructure,consisting of LiNbO_(3)nanoparticles distributed in a carbonate matrix.If tested at 45℃and C/5 rate in pellet-stack SSB full cells with Li_(4)Ti_(5)O_(12)and Li_(6)PS_(5)Cl as anode material and solid electrolyte,respectively,around 80%of the initial specific discharge capacity is retained after 200 cycles(~160 mAh·g^(−1),~1.7 mAh·cm^(−2)).Our results highlight the importance of tailoring the coating chemistry to the electrode material(s)for practical SSB applications. | Seyedhosein Payandeh Florian Strauss Andrey Mazilkin Aleksandr Kondrakov Torsten Brezesinski | 2022 | Nano Research Energy2022，1，3： | 2 |
| 16 | Size-dependent structural and magnetic properties of chemically synthesized Co-Ni-Ga nanoparticles显示文摘形状记忆材料的阶段转变和磁性能被调节成分材料的尺寸定制,例如 nanoparticles。由于为控制尺寸的 Heusler nanoparticles 的合适的合成方法的缺乏,然而,他们的性质和功能的尺寸依赖上没有报告。在这贡献,我们在场选择尺寸的 Co-Ni-Ga Heusler nanoparticles 的第一化学合成。我们也在 30-84 nm 的范围与尺寸报导 biphasic Co-Ni-Ga nanoparticles 的结构和磁性,由一条 SBA-15 nanoporous silicatemplated 途径准备了。粒子尺寸能被控制装载和先锋的集中乐意地调节。部分和 Co-Ni-Ga nanoparticles 的每个阶段的雏晶尺寸是仔细与他们的粒子尺寸有关。提高的磁化和减少的 coercivity 与增加粒子尺寸被观察。居里温度(T Co-Ni-Ga nanoparticles 的 c ) 也取决于他们的尺寸。84 个缩放 nm 的粒子展出最高的 T 在所有已知的 Heusler 之中的 c (1,174 K ) 加重。Co-Ni-Ga nanoparticles 的高级居里温度显示他们在高温度的形状记忆为申请答应候选人基于合金的设备。 | Changhai Wang Aleksandr A. Levin Julie Karel Simone Fabbrici Jinfeng Qian Carlos E. ViolBarbosa Siham Ouardi Franca Albertini Walter Schnelle Jan Rohlicek Gerhard H. Fecher Claudia Felser | 2017 | Nano Research2017，10，10： | 2 |
| 17 | 超宽带多注速调管的模拟研究显示文摘本文介绍了多注速调管的发展历史和现状,以及速调管模拟软件的发展情况。用1.5维软件Klystron -MSU和2.5维软件Arsenal-MSU对超宽带多注速调管进行了设计计算,并对计算结果进行分析,得到了比较好的 输出特性。计算结果表明可以实现该超宽带多注速调管,其带宽10-14%,增益40-50dB,效率40-50%。 | 沈斌 丁耀根 Aleksandr N.Sandalov Vladimir E.Rodjakin Aleksandra N.Chashurina | 2006 | 电子与信息学报2006，28，1： | 2 |
| 18 | Vascular Endothelial Dysfunction and Mortality Risk in Patients With Chronic Heart Failure显示文摘 | Stuart D. Katz Katarzyna Hryniewicz Ingrid Hriljac Kujtim Balidemaj Clarito Dimayuga Alhakam Hudaihed Aleksandr Yasskiy | 2005 | Circulation2005，，3： | 2 |
| 19 | Crystal structure and thermal expansion of perovskites containing uranium(VI) and rare-earth elements显示文摘By the method of high-temperature reactions in solid phase, compounds with the general formula MII(AⅢ2/3U1/3)O3(MII=Sr, AⅢ=Sc, In;MII=Ba, AⅢ=Sc, In, Y, Nd-Lu) were synthesized.Their structures(space groups Fm 3 m and Pnma) were refined by the Rietveld method and morphotropic transition in Ba(Ln2/3U1/3)O3 on the border of Gd-Tb was discovered.By means of high-temperature X-ray diffraction, phase transitions were studied and thermal expansion coefficients were determined. | Aleksandr Knyazev Anna Ershova Nikolai Chernorukov | 2009 | Journal of Rare Earths2009，27，1： | 2 |
| 20 | Variable retention forestry in European boreal forests in Russia显示文摘We explored whether,and to what extent,variable retention(VR)forestry has been applied in European boreal forests in northwestern Russia.Our survey revealed VR since 1910.Between 1910 and the 1960s,the statistics showing how much was retained are largely missing.However,for example,in the 1950s,on a large scale in the Republic of Karelia,up to 200-ha-sized harvesting areas,18–33%,were retention patches with a mean growing stock of 30–40m3 ha−1.In the fellings defined as“incomplete clear fellings,”which were the most common final felling type at that time,11–40%of the growing stock was left.Between the 1960s and the early 1990s,with more efficient harvesting and skidding techniques,conventional clear fellings with a much lower amount of retention were practiced.Concern about the regeneration of harvested areas gradually led to smaller(maximum 50 ha)harvesting areas and the increase of silvicultural activities.Until now,to ensure natural regeneration,patches of understory and 20–25 seed trees(i.e.,ca.15–25m3)per ha have been left permanently in harvesting areas.Landscape-scale retention for protecting ecosystem functions and biodiversity was legislated in 1978 by preserving key biotopes up to 1000 ha in size.Since 2001,promoted by forest certification,the key biotopes,such as paludified forest patches,buffers around water bodies,and habitats of red-listed species,have also been retained in harvesting areas,together with a dispersed retention of different elements.Quantitative estimates of the amount of key biotopes are largely missing.However,estimates of 1–13%in harvesting areas and 23%in whole managed landscapes have been given.VR applied during the last century has emulated natural disturbances and created diverse uneven-aged forest structures with high amounts of diverse coarse woody debris.We conclude that an analysis of past and current retention practices is essential for estimating the global role of Russian forestry.Further decisions on the general direction of Russian forestry and,specifically,retention practices are important to address the global challenges of biodiversity loss and climate change. | Ekaterina Shorohova Sergey Sinkevich Aleksandr Kryshen Ilkka Vanha-Majamaa | 2019 | Ecological Processes2019，8，1： | 1 |
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