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| 1 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 2 | Phenolic composition of skins from four Carmenet grape varieties ( Vitis vinifera L.) during ripening显示文摘 | Elías Obreque-Slier álvaro Pe?a-Neira Remigio López-Solís Alejandro Cáceres-Mella Héctor Toledo-Araya Américo López-Rivera | 2013 | LWT - Food Science and Technology2013，，： | 1 |
| 3 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs 显示文摘 | Ahschul SF Thomas LM Alejandro AS | 1997 | Nucleic Acids Res1997，25，17： | 1 |
| 4 | Phylogeography and population genetic structure of the Talas tuco-tuco (Ctenomys talarum): integrating demographic and habitat histories显示文摘 | Mora Mat?as S Cutrera Ana P Lessa Enrique P Vassallo Aldo I D’Anatro Alejandro Mapelli Fernando J | 2013 | Journal of Mammalogy2013，，2： | 1 |
| 5 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs显示文摘 | Altschul SF Thomas LM Alejandro AS | 1997 | Nucleic Acids Res1997，25，： | 1 |
| 6 | Immunomodulatory oligonucleotide IMT504:Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy显示文摘The immune responses of humans and animals to insults(i.e., infections, traumas, tumoral transformation and radiation) are based on an intricate network of cells and chemical messengers. Abnormally high inflammation immediately after insult or abnormally prolonged proinflammatory stimuli bringing about chronic inflammation can lead to life-threatening or severely debilitating diseases. Mesenchymal stem cell(MSC) transplant has proved to be an effective therapy in preclinical studies which evaluated a vast diversity of inflammatory conditions. MSCs lead to resolution of inflammation, preparation for regeneration and actual regeneration, and then ultimate return to normal baseline or homeostasis. However, in clinical trials of transplanted MSCs, the expectations of great medical benefit have not yet been fulfilled. As a practical alternative to MSC transplant, a synthetic drug with the capacity to boost endogenous MSC expansion and/or activation may also be effective. Regarding this, IMT504, the prototype of a major class of immunomodulatory oligonucleotides, induces in vivo expansion of MSCs, resulting in a marked improvement in preclinical models of neuropathic pain, osteoporosis, diabetes and sepsis. IMT504 is easily manufactured and has an excellent preclinical safety record. In the small number of patients studied thus far, IMT504 has been well-tolerated, even at very high dosage. Further clinical investigation is necessary to demonstrate the utility of IMT504 for resolution of inflammation and regeneration in a broad array of human diseases that would likely benefit from an immunoprotective/immunoregenerative therapy. | Jorge Zorzopulos Steven M Opal Andrés Hernando-Insúa Juan M Rodriguez Fernanda Elías Juan Fló Ricardo A López Norma A Chasseing Victoria A Lux-Lantos Maria F Coronel Raul Franco Alejandro D Montaner David L Horn | 2017 | World Journal of Stem Cells2017，9，3： | 1 |
| 7 | No Longer The Pristine Confines of the World Ocean: A Survey of Exotic Marine Species in the Southwestern Atlantic显示文摘 | Jose Maria (Lobo) Orensanz Evangelina Schwindt Guido Pastorino Alejandro Bortolus Graciela Casas Gustavo Darrigran Rodolfo Elías Juan J. López Gappa Sandra Obenat Marcela Pascual Pablo Penchaszadeh María Luz Piriz Fabrizio Scarabino Eduardo D. Spivak Edua | 2002 | Biological Invasions (-)2002，，1： | 1 |
| 8 | Dietary carbohydrate-to-protein ratio influences growth performance,hepatic health and dynamic of gut microbiota in atlantic salmon(Salmo salar)显示文摘Atlantic salmon(Salmo salar)fed a carbohydrate-rich diet exhibit suboptimal growth performance,along with other metabolic disturbances.It is well known that gut microbes play a pivotal role in influencing metabolism of the host,and these microbes can be modified by the diet.The main goal of the present study was to determine the effect of feeding graded levels of digestible carbohydrates to Atlantic salmon on the distal intestine digesta microbiota at 3 sampling times(i.e.,weeks 4,8 and 12),during a 12-week trial.A low carbohydrate-to-high protein diet(LC/HP,0%wheat starch),a medium carbohydrate-tomedium protein diet(MC/MP,15%wheat starch)or a high carbohydrate-to-low protein diet(HC/LP,30%wheat starch)was fed to triplicate fish tanks(27 to 28 fish per tank).We performed an in-depth characterization of the distal intestine digesta microbiota.Further,growth parameters,liver histology and the expression of genes involved in hepatic neolipogenesis in fish were measured.Fish fed a HC/LP diet showed greater hepatosomatic and viscerosomatic indexes(P=0.026 and P=0.018,respectively),lower final weight(P=0.005),weight gain(P=0.003),feed efficiency(P=0.033)and growth rate(P=0.003)compared with fish fed the LC/HP diet.Further,feeding salmon a high digestible carbohydrate diet caused greater lipid vacuolization,steatosis index(P=0.007)and expression of fatty acid synthase(fas)and delta-6 fatty acyl desaturase(d6fad)(P=0.001 and P=0.001,respectively)in the liver compared with fish fed the LC/HP diet.Although,the major impact of feeding a carbohydrate-rich diet to Atlantic salmon in beta diversity of distal intestine digesta microbiota was observed at week 4(HC/LP vs MC/MP and HC/LP vs LC/HP;P=0.007 and P=0.008,respectively)and week 8(HC/LP vs MC/MP;P=0.04),no differences between experimental groups were detected after 12 weeks of feeding.Finally,at the end of the trial,there was a negative correlation between lactic acid bacteria(LAB)members,including Leuconostoc and Lactobacillus,with hepatic steatosis level,the hepatosomatic and viscerosomatic indexes as well as the expression of fas and d6fad.Weissella showed negative correlation with hepatic steatosis level and the hepatosomatic index.Finally,further research to explore the potential use of LAB as probiotics to improve liver health in carnivorous fish fed fatty liver-induced diet is warranted. | Alejandro Villasante Carolina Ramírez Hector Rodríguez Patricio Dantagnan Adrian Hernandez Elías Figueroa Jaime Romero | 2022 | Animal Nutrition2022，，3： | 1 |
| 9 | Lactic acid bacteria from raw milk as potentially beneficial strains to prevent bovine mastitis显示文摘 | M. Carolina Espeche Matías Pellegrino Ignacio Frola Alejandro Larriestra Cristina Bogni M.E. Fátima Nader-Macías | 2012 | Anaerobe2012，，1： | 1 |
| 10 | CARB-9 a carbenicillinase encoded in the VCR region of Vibrio cholerae Non-01,Non-0139 belongs to a family of cassette-encoded β-lactamases显示文摘 | Alejandro P Roberto GM Hector AS | 2004 | Antimicrob Agents Chemother2004，48，10： | 1 |
| 11 | 森林里的二重奏显示文摘本案位于墨西哥的哈利斯科,其业主是两兄弟,因此整个项目包含了两座独立的楼房(A栋与B栋)。由于该项目的占地面积较为庞大,所以给Elias Rizo Arquitectos的设计团队带来了不小的挑战。设计团队在设计之初与业主们进行了详尽的沟通,并了解到两位业主的需求较为相似,他们并不介意两座房子的设计风格类似,甚至希望将相同的设计语言运用于两座房屋之中,在此基础上,每栋房子还要保留自己的特色。两座房子的所处地形本身就较为复杂,所以房屋的空间结构也因此富有了多变性和层次感。应业主需求,设计团队在两座房屋采用统一设计风格的前提下。 | Elías Rizo Suárez Alejandro Rizo Suarez Kárima Dipp Marcos García 范嘉苑 | 2015 | 现代装饰(家居)2015，0，2： | 0 |
| 12 | Implementation of a virtual multicenter gastrointestinal tumor board to reduce cancer disparities in Argentina显示文摘Given the increasing complexity of cancer care,multidisciplinary tumor boards have become essential in daily clinical oncology practice.The Project Extension for Community Healthcare Outcomes(ECHO)initiative developed an innovative telementoring model using a'hub and spoke'design consisting of a team of experts(hub)that offers a full service to multiple participants(the spokes)during regularly scheduled sessions discussing patients'clinical cases.The Alexander Fleming Cancer Institute in Buenos Aires was the first hub in Latin America to implement Project ECHO for gastrointestinal tumors.In our 3-year experience,80 patients from 37 centers were evaluated within Project ECHO and a range of three to five cases were discussed in each meeting.From our perspective,the impact of this novel approach was a remarkable strategy to reduce care disparities by equalizing access to high-quality medical knowledge in a multidisciplinary environment for medical discussions.Additionally,it was shown to have a cost-effective impact directly on the patients and the local health system,since relevant costs were saved after unnecessary treatments,studies and travel expenses were avoided. | Federico Esteso Natalia Soledad Tissera Juan Manuel O'Connor Romina Luca Eduardo Huertas Fernando Sánchez Loria Ivana Pedraza Alejandro Pairola Fernando Brancato Lisandro Paganini Mariana Kucharczyk Mora Amat Maria Teresa Pombo Mariana Galli Luisina Bruno Luis Caro Andrés Rodriguez Diego Enrico Federico Waisberg Matías Chacón | 2022 | World Journal of Clinical Oncology2022，13，6： | 0 |
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