|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 2 | Space-time surface reconstruction using incompressible flow 显示文摘 | SHARF A ALCANTARA D A LEWINER T | 2008 | ACM Transactions on Graphics2008，27，5： | 1 |
| 3 | Role of roots and shoots in the regulation of the Fe efficiency responses in sunflower and cucumber显示文摘 | ROMERA F J ALCANTARA E DELA GUARDIA M D | 1992 | Plant Physiol1992，85，： | 1 |
| 4 | DOTS-Plus for Multidrug-Resistant Tuberculosis in the Philippines: Global Assistance Urgently Needed显示文摘 | Tupasi TE Quelapio MI Orillaza RB Alcantara C Mira NR Abeleda MR Belen VT Arnisto NM Rivera AB Grimaldo ER Derilo JO Dimarucut W Arabit M Urboda D | 2003 | Tuberculosis (Edinb)2003，83，13： | 1 |
| 5 | Community- Based Therapy for Multidrug-Resistant Tuberculosis in Lima, Peru显示文摘 | Mitnick C Bayona J Palacios E Shin S Furin J Alcantara F Sdnchez E Sarria M Becerra M Fawzi MC Kapiga S Neuberg D Maguire JH Kim JY Farmer P | 2003 | N EnglJ Med2003，348，2： | 1 |
| 6 | Anxi- ety sensitivity and medication nonadherence in patients with uncontrolled hypertension 显示文摘 | ALCANTARA C EDMONDSON D MOISE N | 2014 | J Psychiosom Res2014，77，4： | 1 |
| 7 | Organogenesis and transient genetic transformation of the hybrid Eucalyptus grandis×Eucalyptus urophylla显示文摘 | Alcantara G B D Bespalhok Filho J C Quoirin M | 2011 | Scientia Agricola2011，68，： | 1 |
| 8 | Bicarbonate and low iron level increase root to total plant weight ratio in olive and peach rootstock 显示文摘 | GUARDIA M D ALCANTARA E | 2002 | Plant Nutr2002，25，5： | 1 |
| 9 | Development of an Iron- Based Hardfacing Material Reinforced with Fe - (TiW) C Composite Powder 显示文摘 | Correa E O Alcantara N G Tecco D G | 2007 | Metall Mater Trans A2007，38，： | 1 |
| 10 | IMC-like analytical H∞ design with S/SP mixed sensitivity consideration: Utility in PID tuning guidance 显示文摘 | Alcantara S Zhang W D Pedret C | 2011 | Journal of Process Control2011，21，6： | 1 |
| 11 | Nipple- sparing mastectomy for breast cancer and risk-reducing surgery: the Memorial Sloan-Kettering cancer center ex- perience显示文摘 | de Alcantara Filho P Capko D Barry JM | 2011 | Ann Surg Oncol2011，18，11： | 1 |
| 12 | The relationship between the microstructure and abrasive resistance of a hardfacing alloy in the Fe-Cr-C-Nb-V system显示文摘 | CORREA E O ALCANTARA N G TECCO D G | 2007 | Metallur- gical and Materials Transactions A2007，38，： | 1 |
| 13 | Effect of bicarbonate phosphate and high pH on the reducing capacity of Fe deficient sunflower and cucumber plant显示文摘 | Romera F J Alcantara E Guardia M D | 1992 | Plant Nutri1992，15，： | 1 |
| 14 | Role of roots and shoots in the regulation of the Fe efficiency responses in sunflower and cucmber显示文摘 | ROMERA F J ALCANTARA E GUARDIA M D | 1992 | Physiologia Plantarum1992，85，： | 1 |
| 15 | Real-time parallel hashing on the gpu显示文摘 | ALCANTARA D A SHARF A ABBASINEJAD F | 2009 | ACM Trans Graph2009，28，5： | 1 |
| 16 | Nipple- sparing mastectomy for breast cancer and risk-reducing surgery: the Memorial Sloan-Kettering Cancer Center experience 显示文摘 | de Alcantara Filho P Capko D Barry JM | 2011 | Ann Surg Oncol2011，18，11： | 1 |
| 17 | Anxiety sensitivity and medication nonadherence in patients with uncontrolled hyperten- sion显示文摘 | Alcantara C Edmondson D Moise N | 2014 | J Psychosom Res2014，77，4： | 1 |
| 18 | The relationship between the microstructure and abrasive resistance of a hardfacing alloy in the Fe-Cr-C-Nb-V system 显示文摘 | CORREA E O ALCANTARA NG TECCO D G | 2007 | Metallurgical and Materials Transactions A2007，38，8： | 1 |
| 19 | Mesenchymal stem cells with rhBMP-2 inhibits the growth of canine osteosarcoma cells显示文摘 | Rici RE Alcantara D Fratini P | 2012 | BMC Vet Res2012，8，： | 1 |
| 20 | Development of an iron- based hardfacing material reinforced with Fe-(TiW) C composite powder显示文摘 | Correa E O Alcantara N G Tecco D G | 2007 | Metallurgical and Materials Transactions A: Physical Metallurgy and materials Science2007，38，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员