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| 1 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 2 | Transvenous to arterial Onyx embolization显示文摘 | Albuquerque FC Ducruet AF Crowley RW | 2014 | J Neurointerv Surg2014，6，4： | 1 |
| 3 | Cardiovascular actions of adi- ponectin: Pathophysiologic implications 显示文摘 | Maia - Fernandes T Roncon - Albuquerque R Leite Moreira AF | 2008 | Rev Port Cardiol2008，27，11： | 1 |
| 4 | Endothelin ETA receptors and endothelium partially rnediate the positive inotropic and lusitropic effects of angiotensin Ⅱ显示文摘 | Castro-Chaves P Roneon Albuquerque R Jr Leite-Moreira AF | 2006 | Euro J Pharmacol2006，544，13： | 1 |
| 5 | Effect of green propolis on oral epithelial dysplasia in rats显示文摘 | Cavalcante DR Oliveira PS Gis SM Soares AF Cardoso JC Padilha FF Albuquerque Jr RL | 2011 | Braz J Otorhinolaryngol2011，77，3： | 1 |
| 6 | Technical considerations in the endovaseular management of aneury- sms of the posterior inferior cerebellar artery 显示文摘 | Crowley RW Albuquerque FC Ducruet AF | 2012 | Neurosur- gery2012，71，： | 1 |
| 7 | Severe maxillofacial renal osteodystrophy in two patients with chronic kidney disease 显示文摘 | Lopes ML Albuquerque AF Germano AR | 2015 | J Oral Maxillofac Surg2015，19，3： | 1 |
| 8 | Bile duct confluence: anatomic variations and its classification 显示文摘 | Chaib E Kanas AF Galvo FH D'Albuquerque LA | 2014 | Surg Radiol Anat2014，36，2： | 1 |
| 9 | The evolution of endovascular treatment of carotid cavernous fistulas: a single- center experience显示文摘 | Ducruet AF Albuquerque FC Crowley RW | 2013 | World Neurosurg2013，80，： | 1 |
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