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| 1 | Effect of adipose-derived mesenchymal stem cells on hepatocellular carcinoma: In vitro inhibition of carcinogenesis显示文摘AIM To investigate the effect of adipose-derived mesenchymal stem cells(ADMSCs)and their conditioned media(CM) on hepatocellular carcinoma(HCC) cell tumorigenesis.METHODS The proliferation rate of HepG2 and PLC-PRF-5 HCC cancer cells was measured using the trypan blue exclusion method and confirmed using the cell-counting kit8(commonly known as CCK-8) assay. Apoptosis was detected by flow cytometry using annexin V-FITC. Protein and mRNA expression was quantified by ELISA and real time PCR, respectively. Migration and invasion rates were performed by Transwell migration and invasion assays. Wound healing was examined to confirm the data obtained from the migration assays.RESULTS Our data demonstrated that when co-culturing HCC cell lines with ADMSCs or treating them with ADMSC CM, the HCC cell proliferation rate was significantly inhibited and the apoptosis rate increased. The decreased proliferation rate was accompanied by an upregulation of P53 and Retinoblastoma mRNA and a downregulation of c-Myc and hTERT mRNA levels. More notably, ADMSCs and their CM suppressed the expression of the two important markers of HCC carcinogenicity, alpha-fetoprotein and Des-gamma-carboxyprothrombin. In addition, the migration and invasion levels of HepG2 and PLC-PRF-5 cells significantly decreased, potentially through increased expression of the tissue inhibitor metalloproteinases TIMP-1, TIMP-2 and TIMP-3.CONCLUSION These findings shed new light on a protective and therapeutic role for ADMSCs and their CM in controlling HCC invasiveness and carcinogenesis. | Rim Serhal Nagib Saliba George Hilal Mayssam Moussa Ghada S Hassan Oula El Atat Nada Alaaeddine | 2019 | World Journal of Gastroenterology2019，25，5： | 6 |
| 2 | Real-time reverse transcription-polymerase chain reaction quantification of tumor necrosis factor alpha messenger in human leukocytes显示文摘 | Alaaeddine N De Montigny C Sadouk M | | 0，，9： | 1 |
| 3 | Inhibition of tumor necrosis factor alpha-induced prostaglandin E2 produc tion by the antiinflammatory cytokines interleukin-4,interleukin-10,and interleukin-13 in osteoarthritic synovial fibroblasts:distinct targeting in the signaling pathways显示文摘 | Alaaeddine N Di Battista JA Pelletier JP | 1999 | Arthritis Rheum1999，42，： | 1 |
| 4 | Real-time reverse tran- scription-polymerase chain reaction quantification of tumor necrosis fac- tor alpha messenger in human leukocytes 显示文摘 | Alaaeddine N De-Montigny C Sadouk M | 2011 | Clin Lab2011，57，910： | 1 |
| 5 | Cytokines andtheir role in the pathophysiology of osteoarthritis显示文摘 | Martel-Pelletier J Alaaeddine N Pelletier J-P | 1999 | Front Biosci1999，4，： | 1 |
| 6 | Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation显示文摘 | Alaaeddine N Olee T Hashimoto S | 2001 | Arthritis Rheum2001，44，7： | 1 |
| 7 | Differential effects of IL-8, LIF (Pro-inflammatory) and IL-11 (anti-inflammatory) on TNF-alpha-induced PGE (2) release and on signaling pathways in human OA synovial fibroblasts显示文摘 | Alaaeddine N Di Battista JA Pelletier JP | 1999 | Cytokine1999，11，12： | 1 |
| 8 | Inhibition of rumor necrosis factor alpha-induced prostaglandin E2 production by the antiinflammatory cytokines interleukin-4, interleukin-10,and interleukin-13 in osteoarthritic synovial fibroblasts: distinct targeting in the signaling pathways显示文摘 | Di Battista JA Pelletier JP | 1999 | Arthritis Rheum1999，42，： | 1 |
| 9 | Effect of IL-13 on cytokines, cytokine receptors and inhibitora on human osteoarthritic synovium and synovial fibroblasts 显示文摘 | Pelletier JP Alaaeddine N | 1998 | Osteoarthritis Cart1998，6，： | 1 |
| 10 | Inhibition of tumor necrosis factor alpha-induced prostaglandin E2 production by the antiinflammatory cytokines interleukin-4, interleukin 10, and interleukin13 in osterarthritic synovial fibroblasts:distinct targeting in the siganaling pathways显示文摘 | Alaaeddine N Di Battista J A Pelletier J P | 1999 | Arthritis Rheum1999，42，： | 1 |
| 11 | TNF-et messenger ribonueleic acid(mRNA)in patients with nonalcoholic steatohepatitis显示文摘 | Alaaeddine N Sidaoui J Hilal G | 2012 | Eur Cytokine Netw2012，23，3： | 1 |
| 12 | Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation显示文摘 | OLEE T HASHIMOTO S | 2001 | Arthritis Rheum2001，44，7： | 1 |
| 13 | Real-time reverse tran- scription-polymerase chain reaction quantification of tumor necrosis factor alpha messenger in human leukocytes显示文摘 | Alaaeddine N De Montigny C Sadouk M | 2011 | Clin Lab2011，57，910： | 1 |
| 14 | CD154: an immuneinflammatory mediator in systemic lupus erythematosus and rheumatoid arthritis显示文摘 | Alaaeddine N Hassan GS Yacoub D et aI | 2012 | Clin Dev Immunol2012，2012，49： | 1 |
| 15 | Inhibition of tumor necrosis factor alpha-induced prostaglandin E2 production by the anti-inflammatory cytokines interleukin-4,interleukin-10,and interleukin-13 in osteoarthritic synov ial fibroblasts:distinct targeting in the signaling pathways显示文摘 | Alaaeddine N DI Battista JA Pelletier JP | 1999 | Arthritis Rheum1999，42，： | 1 |
| 16 | Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation显示文摘 | Alaaeddine N Olee T Hashimoto S | 2001 | Arthritis Rheum2001，44，7： | 1 |
| 17 | Early growth response factor-1 mediates prostaglandin E2-dependent transcriptional suppression of cytokine-induced tumor necrosis factor-alpha gene expression in human macrophages and rheumatoid arthritis-affected synovial fibroblasts显示文摘 | Faour WH Alaaeddine N Mancini A | 2005 | J Biol Chem2005，280，10： | 1 |
| 18 | Differential effects of IL - 8, LIF ( pre - inflammatory ) and IL - 11 ( anti - inflammatory) onTNF- alphainduced PGE(2 ) release and onsignalling pathways in hu- man OA synovial fibroblasts 显示文摘 | Alaaeddine N Di BattistaJA Pelletier JP | 1999 | Cytokine1999，11，12： | 1 |
| 19 | Early growth response factor-1 mediates prostaglandin E2-dependent transcriptional suppression of cytokine-indueed tumor necrosis factor-a|pha gene expression in human macrophagcs and rheumatoid arthrltis-affected synovial fibroblasts 显示文摘 | Faour WH Alaaeddine N Mancini A | 2005 | J Biol Chem2005，280，11： | 1 |
| 20 | Design of novel circular lattice photonic crystal fiber suitable for transporting 48 OAM modes显示文摘In this paper,we propose and numerically investigate a novel circular lattice photonic crystal fiber(CL-PCF)using controllable GeO_(2) doped silica,suitable for modes carrying quantized orbital angular momentum(OAM).Large effective index separations between 25 supported vector modes(≥10^(-4))are confirmed over large bandwidth(C+L bands)leading to 48 OAM modes bearing information.The simulations show that the modes in the proposed CLPCF have good features including low and flat dispersion(within 51.82 ps/km/nm),low confinement loss(lower than 0.002 d B/m),high effective mode area(88.5μm^(2))and low nonlinearity(1.22 W^(-1)·km^(-1)).These promising results show that the proposed CL-PCF could be an arguably candidate in fiber-based OAM multiplexing or other applications using OAM states. | Alaaeddine Rjeb Habib Fathallah Saleh Chebaane Mohsen Machhout | 2021 | Optoelectronics Letters2021，17，8： | 1 |
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