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| 1 | Hepatoprotective potential of ethanolic extract of Ziziphus oenoplia(L.)Mill roots against antitubercular drugs induced hepatotoxicity in experimental models显示文摘Objective:To evaluate the hepatoprotective potential of ethanolic(50%) extract of Ziziphus oenoplia(L.) Mill(Z.oenoplia) root against isoniazid(INH) and rifampicin(RIF) induced liver damage in animal models.Methods:Five groups of six rats each were selected for the study.Ethanolic extract at a dose of 150 and 300 mg/kg as well as silymarin(100 mg/kg) were administered orally once daily for 21 d in INH + RIF treated groups.The serum levels of glutamic oxaloacetic transaminase(SGOT),glutamate pyruvate transaminase(SGPT),alkaline phosphatase (SALP),and bilirubin were estimated along with activities of superoxide dismutase,catalase, glutathione S-transferase,glutathione peroxidase,and hepatic melondialdehyde formation. Histopathological analysis was carried out to assess injury to the liver.Result:The considerably elevated serum enzymatic activities of glutamic oxaloacetic transaminase,glutamate pyruvate transaminase,alkaline phosphatase and bilirubin due to INH + RIF treatment were restored towards norma) in a dose dependent manner after the treatment with ethanolic extract of Z.oenoplia roots.Meanwhile,the decreased activities of superoxide dismutase,catalase, glutathione S-transferase and glutathione peroxidase were also restored towards normal dose dependency.In addition,ethanolic extract also significantly prevented the elevation of hepatic melondialdehyde formation in the liver of INH + RIF intoxicated rats in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections.Conclusions:The results of this study slrongly indicate that ethanolic extract of Z.oenoplia has a potent hepatoprotective action against INH + RIF induced hepatic damage in rats. | Ch V Rao AKS Rawat Anil P Singh Arpita Singh Neeraj Verma | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 6 |
| 2 | Deficiency of the complex I of the mitochondrial respiratory chain but improved adenylate control over succinate-dependent respiration are human gastric cancer-specific phenomena显示文摘 | Marju Puurand Nade?da Peet Andres Piirsoo Margot Peetsalu Jaan Soplepmann Meeli Sirotkina Ants Peetsalu Akseli Hemminki Enn Seppet | 2012 | Molecular and Cellular Biochemistry2012，，1： | 2 |
| 3 | Nasal NK-and Tcell lymphomas share the same type of Epstein-Barr latency as nasopharyngeal carcinoma and Hodgkin' s disease显示文摘 | Chiang AKS Tao Q Srivastava G | 1996 | Int J Cancer1996，68，： | 1 |
| 4 | Generalised bone loss in patients with early rheumatoid arthritis 显示文摘 | Gough AKS Lilley J Eyre S | 1994 | Lancet1994，344，： | 1 |
| 5 | Bile acid signaling in fetal tissues:implications for intrahepatic cholestasis of pregnancy显示文摘 | Williamson C Miragoli M Sheikh AKS | | 0，，01： | 1 |
| 6 | Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations 显示文摘 | Angshu BH Terence AKS Rajmone JS | 2000 | Thorax2000，55，2： | 1 |
| 7 | Differences T-cell-receptor gene rearrangement and transcription in nasal lymphomas natural killer and T-cell type显示文摘 | Chiang AKS Srivastava G Lau PWF | 1996 | Hum Pathol1996，27，7： | 1 |
| 8 | Physical and quality attributes of salted cod as affected by the state of rigor and freezing prior to salting显示文摘 | LAURITZSEN K AKSE L JOHANSEN A | 2004 | Food Research International2004，37，7： | 1 |
| 9 | The thyroid andparathyroid glands CT and MR imaging and correlationwith pathology and clinical findings显示文摘 | Weber AL Randolph G Aks oy FG | 2000 | Radiol Clin NorthAM2000，38，5： | 1 |
| 10 | Inorganic mercury and methyl mercury in placentaof Swedish Women 显示文摘 | AKS K AKESSON A BERGLUND M | 2002 | Env Health Perspect2002，110，： | 1 |
| 11 | Comparative pharmacognostic studies of three Phyllanthus species 显示文摘 | Khatoon S Rai V Rawat AKS | 2006 | J Ethnopharmacol2006，104，12： | 1 |
| 12 | Modeling and simulation of compact strength due to particle bonding using a hybrid discretecontinuum approach显示文摘 | KOYNOV A AKSELI I CUITINO A M | | 0，，02： | 1 |
| 13 | Bile acid-induced arrhythmia is mediated by muscarinic M2 receptors in neonatal rat cardiomyocytes显示文摘 | Sheikh AKS Miragoli M Abu-Hayyeh S | | 0，，03： | 1 |
| 14 | Large-scale in vitro expansion of polyclonal C1M^+ CD25b^+isht regulatory T cells human显示文摘 | Hoffmann P Ruediger E Leoni AKS | 2004 | Blood2004，104，： | 1 |
| 15 | Detoxification and energy recovery by wet air oxidation of waste strenms显示文摘 | Akse H N Senden M M G Tels M | | 0，，： | 1 |
| 16 | Qualityassessment of Atlantic cod (Gadus morhua) caught by longlining and trawling at the same and location显示文摘 | ROTABAKKB T SKIPNES D AKSE L | 2011 | Fisheries Research2011，112，12： | 1 |
| 17 | Socialization tactics: longitudinal effects on newcomer adjustment 显示文摘 | ASHFORTIt B E $AKS A M | 1996 | Academy of Man- agement Jottmal1996，39，： | 1 |
| 18 | Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations显示文摘 | Angshu BH Terence AKS Rajmone JS | 2001 | Thorax2001，，2： | 1 |
| 19 | Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations 显示文摘 | Angshu BH Terence AKS Rajmone JS | 2000 | Thorax2000，55，2： | 1 |
| 20 | Case files of the Toxikon Consortium in Chicago:survival after intentional ingestion of hydrofluoric acid显示文摘 | Whiteley PM Aks SE | 2010 | J Med Toxicol2010，6，3： | 1 |
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