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| 1 | 国产香烟主流烟雾中多环芳烃的含量显示文摘目的检测20种主要国产品牌香烟主流烟雾中多环芳烃与焦油含量,并分析其是否有相关关系。方法按ISO国际标准吸取香烟主流烟雾中颗粒物,提取颗粒物中的多环芳烃,高效液相法测定荧蒽(FLUO),芘(pyrene熏PY),苯并(g熏h熏j)(BGP),苯并(a)蒽眼B穴a雪A演,(CRY)熏苯并(a)芘眼B穴a雪P演,苯并(b)荧蒽眼B(b)F演,苯并(k)荧蒽眼B(k)F演,二苯并(a熏h)蒽(DBA)9种多环芳烃含量,并检测烟雾中焦油、尼古丁含量。结果20种主要品牌香烟主流烟雾中多环芳烃主要成分含量均值从高到低依次为芘,荧蒽,CRY,苯并(a)蒽,二苯并(a熏h)蒽,苯并(a)芘,苯并(g熏h熏j),苯并(b)荧蒽熏苯并(k)荧蒽。总PAHs平均含量为714.8ng/支,其中芘、荧蒽等非致癌性组分占总PAHs的93%;致癌性多环芳烃平均含量为89.4ng/支,以苯并(a)芘和二苯并(a熏h)蒽为主要成分。总PAHs、致癌性PAHs含量与焦油含量的相关系数和P值分别为0.647,0.002,0.554,0.011。结论国产香烟主流烟雾中均可检出9种多环芳烃,总PAHs、致癌性PAHs含量与焦油含量呈正相关,提示焦油可作为估计烟雾中致癌多环芳烃含量、评价健康危害的指标。 | 黄曙海 葛宪民 汤俊豪 AKPAN Victor LODOVICI Maura DOLARA Piero | 2006 | 环境与健康杂志2006，23，1： | 12 |
| 2 | 臭腹腺蝗(直翅目:锥头蝗科)胃盲囊的异速生长和功能特性(英文)显示文摘通过对臭腹腺蝗Zonocerusvariegatus (直翅目 :锥头蝗科 ) 6个若虫期及成虫期主消化道和胃盲囊分段进行解剖和测量 ,对其胃盲囊的异速生长和功能特性进行了研究。结果表明 ,胃盲囊和主消化道的生长是不同速的。胃盲囊前段较后段生长速率更高 ,但两者生长速率显著相关。消化道和胃盲囊的平均长度亦显著相关。随年龄增长 ,消化道的生长速率降低 ,而胃盲囊的生长速率上升。与胃盲囊前段功能相同 ,胃盲囊后段亦具有消化和吸收功能 。 | Bassey E. AKPAN Tony G. OKORIE | 2003 | 昆虫学报2003，46，5： | 4 |
| 3 | Comparison of antioxidant activity of insulin, Ocimum gratissimum L., and Vernonia amygdalina L. in type 1 diabetic rat model显示文摘OBJECTIVE: Diabetes mellitus(DM) is known to be associated with increase of oxidative stress products. The direction of effect of any treatment on these products could therefore be a reliable measure of its efficacy on DM. So the aim of this study was to investigate the activity of insulin, Ocimum gratissimum L.(OG) and Vernonia amygdalina L.(VA) on oxidative stress products.METHODS: Thirty-six female Wistar rats weighing 150–200 g were randomly divided into six groups of six rats each. Thirty rats were induced for type 1 DM(DM1) with a single intraperitoneal administration of 65 mg/kg body weight of streptozotocin. Group 1 was normal control and was administered distilled water while Group 2 served as DM1 control group; Groups 3, 4, 5 and 6 were diabetic rats treated with 208 mg/kg OG(DM1 + OG), 52 mg/kg VA(DM1 + VA), 208 mg/kg OG + 52 mg/kg VA(DM1+OG +VA) and 0.16 IU insulin(DM1 + insulin) respectively. Determination of methemoglobin and sulfhemoglobin was achieved by the absorption spectrum principle. Red blood cell(RBC) catalase was assayed by continuous spectrophotometric method.RESULTS: The RBC catalase concentration was significantly decreased in the DM1 and DM1+VA groups when compared with the normal control. DM1 + OG significantly increased RBC-catalase when compared to DM1. The methemoglobin concentration was significantly reduced in the DM1, DM1 + VA, DM1 + OG + VA and DM1 + insulin groups when compared to the normal control group. The sulfhemoglobin concentration was significantly increased in the diabetic control and the diabetic treated groups when compared to the normal control. DM1 + OG reduced the sulfhemoglobin concentration when compared to DM1. The blood glucose concentration of all the diabetic groups was significantly raised compared to normal control. OG, VA and insulin significantly reduced the blood glucose concentration with the efficacy of OG and VA higher than insulin.CONCLUSION: Adverse alteration of oxidative indices were observed in type 1 DM model. Treatment with OG and insulin showed potent antioxidant activity, while the hypoglycemic efficacy of OG and VA were higher than insulin. | Uduak Akpan Okon Idorenyin Udo Umoren | 2017 | Journal of Integrative Medicine2017，15，4： | 3 |
| 4 | Ethnopharmacology,phytochemistry,and biological activities of Cymbopogon citratus(DC.) Stapf extracts显示文摘Cymbopogon citratus is a widely distributed perennial herb belonging to the Poaceae family and has been extensively consumed for its medicinal,cosmetic,and nutritional effects for centuries.A large number of reports have been published describing the pharmacological,biological,and therapeutic actions of this herb.In this review,we summarized the literatures on related studies(up to January,2014) that highlighted the pharmacologic and biological effects of the major phytochemicals isolated from C.citratus extracts and its essential oil.The components of the essential oils found in C.citratus have a similar pharmacokinetic properties,including absorption,distribution,metabolism,and excretion.They are quickly absorbed following oral,pulmonary,and dermal administration.Based on the published reports,it can also be inferred that,after absorption from the small intestine,some phytochemicals in C.citratus can undergo oxidation,glucuronidation,sulfation,and/or O-methylation.Excretion is through urine,feces and/or expired volatiles.The biotransformation reactions of C.citratus bioactive constituents are essential for its relatively safe consumption and therapeutic applications.The data available so far warrant further studies evaluating C.citratus pharmacokinetics.Reliable pharmacokinetic data in humans would be critical for a better understanding of the the systemic handling of C.citratus. | Christopher E Ekpenyong Ernest Akpan Azah Nyoh | 2015 | Chinese Journal of Natural Medicines2015，13，5： | 3 |
| 5 | Antiplasmodial and antipyretic studies on root extracts of Anthocleista djalonensis against Plasmodium berghei显示文摘 | Enomfon J Akpan Jude E Okokon Idongesit C Etuk | 2012 | Asian Pacific Journal of Tropical Disease2012，，1： | 2 |
| 6 | Antimalarial potency of the leaf extract of Aspilia africana(Pers.) C.D.Adams显示文摘Objective:To investigate the antimalarial activity of ethanol extract of Aspilin africana (A.africana) leaf.Methods:The ethanol extract of A.africana leaf(100-400 mg/kg) was screened for blood schizonticidal effect against chloroquine-sensitive Plasmodium berghei(P. berghei) in mice both in early and established models of antimalarial studies.Results:The leaf extract exhibited significant(P<0.05) antiplasmodial activity in 4-day early infection and in established infection tests with a considerable mean survival time comparable to that of standard drug,chloroquine(10 mg/kg).Conclusions:The findings show thai ethanol extract of A.africana leaf possesses potent antiplasmodial activity which justify the use in ethnomedicine and can be developed in malaria therapy. | Akuodor Godwin Christian Amos Grace Mfon Essien Augustine Dick Essien David-Oku Akpan Joseph Linus Ezeokpo Basil Chukwuma | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，2： | 2 |
| 7 | Sensitivity of a mobite manipulator response to system parameters显示文摘 | Akpan U O Kujath M R | 1998 | ASME Journal of Vibration and Acoustics1998，120，： | 1 |
| 8 | Hydrolysis of raw tuber starches by amylase of Aspergillus niger AM07 isolated from the soil 显示文摘 | OMEMU A AKPAN I BANKOLE M | 2005 | Afr J Biotechnol2005，4，1： | 1 |
| 9 | Parameters affecting the photocatalytic degradation of dyes using Ti02-based photocatalysts显示文摘 | Akpan U G Hameed B H | 2009 | Journal of Hazardous Materials2009，170，23： | 1 |
| 10 | Astrovirus infection in children in lagos,Nigeria显示文摘 | Ayolabi C Ojo D Akpan I | 2012 | Afr J Infect Dis2012，6，1： | 1 |
| 11 | An Assessment of the Prevalence of Elder A-buse and Neglect in Akwa Ibom State,Nigeria显示文摘 | Akpan ID Umobong ME | 2013 | Devel Count Stud2013，3，5： | 1 |
| 12 | Clinical pharmacologic investigations with carvedilot,a new P-blocher with direct vasodilator activity显示文摘 | Von Moellendorff E Abshagen V Akpan W | 1986 | Clic Pharmacol Ther1986，39，： | 1 |
| 13 | Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/ neuron loss and improves neurological function after stroke显示文摘 | Akpan N Serrano-Saiz E Zacharia BE | 2011 | J Neurosci2011，31，24： | 1 |
| 14 | Hydrolysis of raw tuber starches by amylase of Aspergillus niger AM07 isolated from the soil显示文摘 | Omenu AM Akpan l Bankole MO | 2005 | African Journal of Biotechnology2005，4，1： | 1 |
| 15 | Parameters affecting the photo - catalytic degradation of dyes using TiO2 -based photocata- lysts:A review 显示文摘 | Akpan U G Hameed B H | 2009 | Journal of Hazardous Materials2009，170，23： | 1 |
| 16 | Hydrolysis of law tuber starches by amylase of Aspergillus niger AM07 isolated from the soil显示文摘 | Omenu A M Akpan I Bankole M O | 2005 | African Journal of Biotechnology2005，4，1： | 1 |
| 17 | Heavy metal trends in the Calabar River, Nigeria显示文摘 | AKPAN E EKPE U J IBOK U J | 2002 | Environmental Geology2002，42，1： | 1 |
| 18 | Parameters affecting the photocatalyfic degradation of dyes using TiO2-basrd photocatalysts : A review 显示文摘 | Akpan U G Hameed B H | 2009 | J Hazard Mater2009，170，1： | 1 |
| 19 | Hydrolysis of raw tuber starches by amylase of Aspergillus niger AM07 isolated from the soil显示文摘 | Omemu AM Akpan I Bankole MO | 2005 | African Journal of Biotechnoiogy2005，4，1： | 1 |
| 20 | Mould temperature and mechanical properties of cast aluminum-silicon carbide composite 显示文摘 | ADEOSUN S O AKPAN E I ABIODUN D | 2013 | International Journal of Materials and Chemistry2013，3，4： | 1 |
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