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| 1 | Prognostic roles of preoperative α-fetoprotein and des-γ-carboxy prothrombin in hepatocellular carcinoma patients显示文摘AIM:To clarify the utility of using des-γ-carboxy prothrombin(DCP)andα-fetoprotein(AFP)levels to predict the prognosis of hepatocellular carcinoma(HCC)in patients with hepatitis B virus(HBV)and the hepatitis C virus(HCV)infections.METHODS:A total of 205 patients with HCC(105patients with HBV infection 100 patients with HCV infection)who underwent primary hepatectomy between January 2004 and May 2012 were enrolled retrospectively.Preoperative AFP and DCP levels were used to create interactive dot diagrams to predict recurrence within 2 years after hepatectomy,and cutoff levels were calculated.Patients in the HBV and HCV groups were classified into three groups:a group with low AFP and DCP levels(LL group),a group in which one of the two parameters was high and the other was low(HL group),and a group with high AFP and DCP levels(HH group).Liver function parameters,the postoperative recurrence-free survival rate,and postoperative overall survival were compared between groups.The survival curves were compared by logrank test using the Kaplan-Meier method.Multivariate analysis using a Cox forward stepwise logistic regression model was conducted for a prognosis.RESULTS:The preoperative AFP cutoff levels for recurrence within 2 years after hepatectomy in the HBV and HCV groups were 529.8 ng/m L and 60 m AU/m L,respectively;for preoperative DCP levels,the cutoff levels were 21.0 ng/m L in the HBV group and 67 m AU/m L in the HCV group.The HBV group was significantly different from the other groups in terms of vascular invasion,major hepatectomy,volume of intraoperative blood loss,and surgical duration.Significant differences were found between the LL group,the HL group,and the HH group in terms of both mean disease-free survival time(MDFST)and mean overall survival time(MOST):64.81±7.47 vs 36.63±7.62 vs 18.98±6.17mo(P=0.001)and 85.30±6.55 vs 59.44±7.87 vs46.57±11.20 mo(P=0.018).In contrast,the HCV group exhibited a significant difference in tumor size,vascular invasion,volume of intraoperative blood loss,and surgical duration;however,no significant difference was observed between the three groups in liver function parameters except for albumin levels.In the LL group,the HL group,and the HH group,the MDFST was 50.09±5.90,31.01±7.21,and 14.81±3.08 mo(log-rank test,P<0.001),respectively,and the MOST was 79.45±8.30,58.82±7.56,and 32.87±6.31 mo(log-rank test,P<0.001),respectively.CONCLUSION:In the HBV group,the prognosis was poor when either AFP or DCP levels were high.In the HCV group,the prognosis was good when either or both levels were low;however,the prognosis was poor when both levels were high.High levels of both AFP and DCP were an independent risk factor associated with tumor recurrence in the HBV and HCV groups.The relationship between tumor marker levels and prognosis was characteristic to the type of viral hepatitis. | Makoto Meguro Toru Mizuguchi Toshihiko Nishidate Kenji Okita Masayuki Ishii Shigenori Ota Tomomi Ueki Emi Akizuki Koichi Hirata | 2015 | World Journal of Gastroenterology2015，21，16： | 16 |
| 2 | Transport of cephalexin to the cerebrospinal fluid directly from the nasal cavity 显示文摘 | Sakane T Akizuki M Yoshida M | 1991 | J Pharm Pharmacol1991，43，6： | 1 |
| 3 | Harvest of sural nerve grafts using the endoscope 显示文摘 | KOBAYASHI S AKIZUKI T SAKAI Y | 1995 | Ann Plast Surg1995，35，： | 1 |
| 4 | Course of psychologicaldistress and its predictors in advanced non -small cell lung cancerpatients显示文摘 | Akechi T Okuyama T Akizuki N | 2006 | Psychooncology2006，15，6： | 1 |
| 5 | Histological evelation of alveolar ridge augmentation using injectable calcium phosphate bone cement in dogs 显示文摘 | SATO I AKIZUKI T ODA S | 2009 | Journal of Oral Rehabilitation2009，36，10： | 1 |
| 6 | Reconstruction of the coracoclavicular ligaments with tendon grafts: a comparative biomechanical study显示文摘 | Lee S J Nicholas S J Akizuki K H | 2003 | Am J Sports Med2003，31，5： | 1 |
| 7 | The longterm outcome of high tibial osteotomy:a ten-to 20-year follow-up显示文摘 | Akizuki S Shibakawa A Takizawa T | 2008 | J Bone Joint Surg(Br)2008，90，5： | 1 |
| 8 | Foreign body goni- tis caused by a broken poly -L -lactic acid screw显示文摘 | Takizawa T Akizuki S Horiuchi H | 1998 | Ar- throscopy1998，14，3： | 1 |
| 9 | Diminution of the number of gamma delta T lymphoeytes in hepatocellular earcinoma patients treated with transeatheter arterial embolization显示文摘 | Akizuki S Magara T Tanaka T | 1998 | Nihon-Meneki-Gakkai-Kaishi1998，21，3： | 1 |
| 10 | Blockade of T-type voltage-dependent Ca2+ channels by benidipine A dihydropyridine calcium chan- nel blocker,inhibits aldosterone production in human adrenocortical cell line NCI-H295 R 显示文摘 | Akizuki O lnayoshi A Kitayama T | 2008 | Eur J Pharmacol2008，584，： | 1 |
| 11 | 显示文摘 | Okamura K Akizuki T | 1995 | J Mater Science1995，30，13： | 1 |
| 12 | Intracellular calcium affects neutrophil chemoattractant expression by macrophages in rats with cerulein-induced pancreatitis显示文摘 | Yamaguchi Y Akizuki E Matsumura F | 1998 | Dig Dis Sci1998，43，4： | 1 |
| 13 | Long noncoding RNA NEATl-dependent SFPQ relocation from promoter region to pa- raspeckle mediates IL8 expression upon immune stimuli 显示文摘 | Imamura K Imamachi N Akizuki G | 2014 | Mol Cell2014，53，3： | 1 |
| 14 | Long noneod- ing RNA NEATl-dependent SFPQ relocation from promot- er region to paraspeekle mediates IL8 expression upon im- mune stimuli显示文摘 | Imamum K Imamachi N Akizuki G | 2014 | Mol Cell2014，53，： | 1 |
| 15 | Effect of COD/NO3-N ratio and seed sludge on simultaneous methanogenesis and denitrification in intermittent organic solid waste treatment显示文摘 | S Akizuki K Izumi N Nagao | 2013 | Intemational Biodeterioratien & Biodegradation2013，84，： | 1 |
| 16 | Blockade of T-type voltage-dependent Ca2 + channels by benidipine,a dihydropyridine calcium channel blocker,inhibits aldosterone production in human adrenocortical cell line NCI-H295R显示文摘 | Akizuki O Inayoshi A Kitayama T | | 0，，2： | 1 |
| 17 | Fixation of the NexGen HA-TCP-coated cementless,screwless total knee arthroplasty:comparison with conventional cementless total knee arthroplasty of the same type显示文摘 | Gejo R Akizuki S Takizawa T | | 0，，04： | 1 |
| 18 | Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from Patients with polymyositis scleroderma overlap显示文摘 | Mimori T Akizuki M Yamagata H | 1981 | Clin Invest1981，68，3： | 1 |
| 19 | Prospective nonrandomized comparison between pylorus-preservingand subtotal stomach--preserving pancreaticoduodenectomy from the perspectives of DGE occurrence andpostoperative digestive functions显示文摘 | Akizuki E Kimura Y Nobuoka T | 2008 | J Gastrointnst Surg2008，12，7： | 1 |
| 20 | Direct drug transport from the nasal cavity to the cerebrospinal fluid: the relation to the lipophilicity of the drug 显示文摘 | ] SAKANE T AKIZUKI M YAMASHITA S et a1 | 1991 | Chem Pharm Bull1991，39，9： | 1 |
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