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| 1 | Constitutive androstane receptor agonist, TCPOBOP,attenuates steatohepatitis in the methionine choline-deficientdiet-fed mouse显示文摘AIM:To ascertain whether constitutive androstane receptor(CAR)activation by 1,4-bis-2-(3,5,-dichloropyridyloxy)benzene(TCPOBOP)modulates steatohepatitis in the methionine choline-deficient(MCD)diet-fed animal.METHODS:C57/BL6 wild-type mice were fed the MCD or standard diet for 2 wk and were treated with either the CAR agonist,TCPOBOP,or the CAR inverse agonist,androstanol.RESULTS:Expression of CYP2B10 and CYP3A11,known CAR target genes,increased 30-fold and 45-fold,respectively,in TCPOBOP-treated mice fed the MCD diet.TCPOBOP treatment reduced hepatic steatosis(44.6 ± 5.4% vs 30.4 ± 4.5%,P < 0.05)and serum triglyceride levels(48 ± 8 vs 20 ± 1 mg/dL,P < 0.05)in MCD diet-fed mice as compared with the standard diet-fed mice.This reduction in hepatic steatosis was accompanied by an increase in enzymes involved in fatty acid microsomal ω-oxidation and peroxisomal β-oxidation,namely CYP4A10,LPBE,and 3-ketoacyl-CoA thiolase.The reduction in steatosis was also accompanied by a reduction in liver cell apoptosis and inflammation.In contrast,androstanol was without effect on any of the above parameters.CONCLUSION:CAR activation stimulates induction of genes involved in fatty acid oxidation,and ameliorates hepatic steatosis,apoptosis and inflammation. | Edwina S Baskin-Bey Akira Anan Hajime Isomoto Steven F Bronk Gregory J Gores | 2007 | World Journal of Gastroenterology2007，13，42： | 3 |
| 2 | Tubular bacterial cellulose gel oriented fibrils on the curved surface显示文摘 | Ananda P Akira K Hidemitsu F | 2008 | Polymer2008，49，4： | 1 |
| 3 | Silicom Single- Electron Devices and Their Applications 显示文摘 | Yasuo T Akira F Yukinori O Katsumi M | 2000 | IEEE Trans Electron Device2000，13，： | 1 |
| 4 | Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8显示文摘 | Heil F Hemmi H Hochrein H Ampenberger F Kirschning C Akira S | 2004 | Science2004，303，： | 1 |
| 5 | Water repellent surface impregnation for extension of service life of reinforced concrete structmes in marine environments:the role of cracks显示文摘 | Dai J G Akira Y Wittmann F H | 2010 | Cement and Concrete Composites2010，32，2： | 1 |
| 6 | Water repellent surface impregnation for extending the service life of reinforced concrete structures in marine environments: The role of cracks 显示文摘 | Dai J G Akira Y Wittmann F H | 2010 | Cement and Concrete Composites2010，，32： | 1 |
| 7 | Cross-sectional imagingin Crohn's disease 显示文摘 | Akira F Takao S Michio Y | 2004 | Radiographics2004，24，： | 1 |
| 8 | 显示文摘 | KEN H MAMORU F AKIRA S | 2007 | J Phys Chem A2007，111，11： | 1 |
| 9 | Present state and future prospects of powder metallurgy parts for automotive applications 显示文摘 | AKIRA F | 2001 | Materials Chemistry and Physics2001，67，： | 1 |
| 10 | Titanium dioxide photocatalysis 显示文摘 | Akira F Tata N R Donald A T | 2000 | J Photochem Photobiology C: Photochem Rev2000，1，： | 1 |
| 11 | Photocatalysis on TiO2 surfaces principles,mechanisms and selected results显示文摘 | Tryk A Donald C Akira F | 2003 | Chemical Physics2003，95，2： | 1 |
| 12 | TiO2 photoeatalysis and related surface phenomena 显示文摘 | AKIRA F ZHANG Xin-tong DONALD A T | 2008 | Surface Science Reports2008，63，： | 1 |
| 13 | Oxidation kinetics of MgO-C refractory bricks显示文摘 | Mohammad A F S Akira Y | 2002 | Ceram Int2002，28，8： | 1 |
| 14 | Double-ballon enteroscopy inpatients with GI bleeding of obscure origin 显示文摘 | Noriaki M Shinji T Akira F | 2006 | Gastrointest Endose2006，64，1： | 1 |
| 15 | S-Nitrosylated pegylated hemoglobin reduces the size of cerebral infarction in rats显示文摘 | AKIRA T KUNIHIKO N K DAI F | 2009 | Artificial Organs2009，33，2： | 1 |
| 16 | Development of the ultra-low-fuel-consumption hybrid car-INSIGHT显示文摘 | Koichi F I Akira F Masaaki S | 2001 | JSAE Review2001，22，1： | 1 |
| 17 | Paracrine regulatin of angiogenesis and adipose differentiation during in vivo adipogenesis显示文摘 | Dai F Akira U Dan GD | 2003 | Circ Res2003，93，： | 1 |
| 18 | Inhibition of platelet aggregation by medermycin and it' s related isochromanequinone antibiotics 显示文摘 | Akira N Nobuko F Kohji Y J | 1987 | J Antibiotics1987，40，7： | 1 |
| 19 | Titanium dioxide photocatalysis 显示文摘 | Akira F Tara N R Donald A T | 2000 | Journal of Photochemistry and Photobiology C: Photochemistry Reviews2000，1，： | 1 |
| 20 | Diffuse panbronchiolitis: evaluation with high-resolution CT显示文摘 | Akira M Kitatani F Lee YS | 1988 | Radiology1988，168，2： | 1 |
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