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| 1 | A PI3K/Akt/mTOR pathway mediates and PTEN antagonize tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1显示文摘 | Ozes O N Akca H Mayo L D | 2001 | PNAS2001，98，8： | 1 |
| 2 | Pilot-scale anaerobic treatment of domestic wastewater in upflow anaerobic sludge bed and anaerobic baffled reactors at ambient temperatures 显示文摘 | Ayaz S C Akca L Aktas O | 2011 | Desalination and Water Treatment2011，46，13： | 1 |
| 3 | Treatment of wastewater by natural sys- tems 显示文摘 | S C Ayaz L Akca | 2001 | Environ Int2001，，26： | 1 |
| 4 | Nitrogen removal during secondary treatment by aquatic system显示文摘 | NALBUR B AKCA L BAYHAN H | 2003 | Water Science and Technology2003，48，1112： | 1 |
| 5 | A phosphatidylinositol 3 - Kinase / Akt / mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-l显示文摘 | Oaes O N Akca H Nayo L D | 2001 | Proc Natl Acad Sci USA2001，10，： | 1 |
| 6 | A model for optimum design of activated sludge plants 显示文摘 | Akca L Kinaci C Karpuzcu M | 1993 | Water Research1993，27，9： | 1 |
| 7 | A model for optimum design ofactivated sludge plants显示文摘 | Akca L Kinaci C Karpuzcu M | 1993 | Water Res1993，27，9： | 1 |
| 8 | Performance of a pilot- scale, three-stage constructed wetland system for domestic wastewater treatment 显示文摘 | Tuncsiper B Ayaz S Akca L | 2009 | Environmental Technology2009，30，： | 1 |
| 9 | Appraisal and development of the Taq Taq field, Kurdistan region, Iraq显示文摘 | Garland C R Abalioglu I Akca L | 2010 | Petroleum Geology Conference series2010，7，： | 1 |
| 10 | Existence of solutions of a semilinear functional differential evolution nonlocal problem显示文摘 | Byszewski L Akca H | 1998 | Nonlinear Anal1998，34，： | 1 |
| 11 | Nitrogen Removal during Secondary Treatment by Aquatic System显示文摘 | NALBUR B AKCA L BAYHAN H | 2003 | Water Science and Technology2003，48，1112： | 1 |
| 12 | A model for optimum design of activated sludge plants显示文摘 | Akca L Kinaci C Karpuzcu M | 1993 | Water Res1993，27，： | 1 |
| 13 | A phosphatidylinositol 3- Kinase/ Akt/ roTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1 显示文摘 | Ozes O N Akca H Mayo L D | 2001 | Proc Natl Acad Sci USA2001，98，8： | 1 |
| 14 | Existence of solutions of a semilinear functional-differential evolution nonlocal prob-lem 显示文摘 | BYSZEWSKI L AKCA H | 1998 | Nonlinear Anal:Theor Meth Appl1998，34，1： | 1 |
| 15 | Nitrogen removal during secondary treatment by aquatic system 显示文摘 | Nalbur B Akca L Bayhan H | 2003 | Water Science and Technology2003，48，1112： | 1 |
| 16 | Antimicrobial activity against periodontopathogenic bacteria,antioxidant and cytotoxic effects of various extracts from endemic Thermopsis turcica显示文摘Objective:To investigate the in vitro antimicrobial potential of Thermopsis turcica Kit Tan,Vural&Kckdk against periodoutopathogenie bacteria,its antioxidant activity and cytotoxic effect on various cancer cell lines.Methods:In vitro antimicrobial activities of elhanol.methanol,ethyl acetate(ElAc,n-hexane and water extracts of Thermopsis turcica herb against periodontopathogenic bacteria,Aggregatibacter actinnmycelemconilans ATCC 29523 and Porphyromonas gingivalis ATCC 33277 were tested by agar well diffusion,minimum inhibitory concentration(MIC)and minimal bactericidal concentration(MBC),Antioxidant properties of the extracts were evaluatod by 1,1-diphenyl-2-picryl-hydrazyl radical scavenging activity and p-carotene bleaching methods.Amounts of phenolic contents of the extracts were also analysed by using the Folin-Ciocalteu reagent.Additionally,cytotoxic activity of the extracts on androgcn-insensilivc prostate cancer,androgen—sensitive prostate cancer,chronic myelogenous leukemia and acute promyelocytic leukemia bunian cancer cell lines were determined by 3-4,5-dimelhylthiazol-2-yh-2,5-diphenyltclrazolium bromide assay.Human gingival fibroblast cells were used as a control.Results:Our data showed that ELAc extract had the highest antimicrobial effect on Aggregatibacter actinomycetemitans(MIC:1.562 mg/ml_MHC:3.124 mg/ml.)and Porph yromonas gingiralis(MIC:0.781 mg/mL,MBC:1.562 mg/mL).In antioxidant assays.ElAc extract exhibited also the highest radical scavenging activity[IC_(50)=(30.0±0.3)μg/ml.]and the highest inhibition[(74.35±0.30)%]|against lineloic acide oxidation.The amount of phenolic content of it was also the highest[(l62.5±l.2)μg/mg gallic acid].In cytotoxic assay,only etbanol[IC_(50)=(80.00±1.21)μg/ml.]and EtAc extract[IC_(50)=(70.0±0.9)μg/ml]were toxic on acute promyeloeytic leukemia cells at 20—100μg/mL.P<0.05>.However,no toxic effect was observed on human gingival fibroblast cells.Cunclusions:According to our findings,owing to its antioxidant and cytotoxic potential,EtAc exlrael might include anticancer agents for acute promyelocytic leukemia. | Elif Burcu Bali Leyla Acik Glin Akca Meral Sarper Mualla Pinar Eli Ferit Avcu Mecit Vural | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，7： | 0 |
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