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| 1 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 2 | Early postoperative erythromycin breath test correlates with hepatic cytochrome P4503A activity in liver transplant recipients 显示文摘 | Schmidt LE Olsen AK Stentoft K | 2001 | Clin Pharmacol Ther2001，70，5： | 2 |
| 3 | CTLA- 4 Gene Polymorphism confers susceptibility to primary biliary cirrhosis 显示文摘 | Agawal k Jones DE Daly AK | 2000 | J Hepatol2000，32，： | 2 |
| 4 | Anatomic restoration technique of continence mechanism and preservation of puboprostatic collar:a novel modification to achieve early urinary continence in men undergoing robotic prostatectomy显示文摘 | Tewari AK Bigelow K Rao S | 2007 | Urology2007，，04： | 2 |
| 5 | 高度近视伴色觉缺失的家系分析(英文)显示文摘目的:评估高度近视伴色觉缺失患者的遗传学特征和临床表现方法:就同一家族4代42个成员中有8位患者给予了详细的眼科检查,Ishihara盘和FM100H试验检测患者有无红绿色觉缺失,全视野视网膜电图评价其视网膜功能。结果:患者8位均因高度近视视力下降,其中6例有红绿色觉缺失,眼底检查显示以弥漫性视网膜脉络膜萎缩为特征的近视改变。2例患者ERG检查出现视杆细胞的暗适应异常和视锥细胞的反应消失,根据家系,红绿色觉缺失属X连锁的隐性遗传。结论:在这个家族成员中,同时发生的高度近视和色觉缺失可能有共同的遗传学基础。 | Nimet nay Gündogan Ay■e Gül Koak Altinta■ Nezih Durmazlar Koray Gümüs Zerrin Yilmaz Kemal Ksemehmetoglu | 2007 | 国际眼科杂志2007，7，3： | 2 |
| 6 | A composite tissue-engineered trachea using sheep nasalchondrocyte and epithelial cells 显示文摘 | Kojima K Bonassar LJ Roy AK | 2003 | FASEB J2003，17，8： | 1 |
| 7 | Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies显示文摘 | Haug K Warnstedt M Alekov AK | 2003 | Nat Genet2003，33，4： | 1 |
| 8 | Soluble thrombomodulin activity and soluble thrombomodulin antigen in plasma 显示文摘 | Ohlin AK Larsson K Hansson M | 2005 | J Thromb Haemost2005，3，5： | 1 |
| 9 | Risk of respiratory morbidity in term infants delivered by elective caesarean section:Cohort study显示文摘 | Hansen AK Wisborg K Uldbjerg N | 2008 | BMJ2008，336，7635： | 1 |
| 10 | Cryptococcal cell morphology affects host cell interactions and pathogenicity显示文摘 | Okagaki LH Strain AK Nielsen JN Charlier C Baltes NJ Chr6tien F Heitman J Dromer F Nielsen K | 2010 | PLoS Pathog2010，6，10： | 1 |
| 11 | Studies on antidiarrhoeal activity granatum seed extract in rasts显示文摘 | Das AK Mandal SC Banenjee S K | 1999 | Ethnopharmacology1999，68，8： | 1 |
| 12 | The influence of micropores on the dynamic-mechanical properties on reinforced epoxy foams 显示文摘 | Bledzki AK Kurek K Gassan J | 1998 | Mater Sci1998，33，： | 1 |
| 13 | Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies 显示文摘 | Haug K Warnstedt M Alekov AK | 2003 | Nat Genet2003，33，4： | 1 |
| 14 | Changes in stiffness of demineralized dentin following application of col- lagen crosslinkers 显示文摘 | Bedran-Russo AK Pashley DH Agee K | 2008 | J Biomed Mater Res B Appl Bio- mater2008，86，2： | 1 |
| 15 | Sorafenib and its tosylate salt:a multikinase inhibitor for treating cancer显示文摘 | Ravikumar K Sridhar B Bhujanga Rao AK | 2011 | Acta Crystallogr C2011，67，1： | 1 |
| 16 | The cagA status of Helicobacter pylori isolates from dyspeptic children in Turkey显示文摘 | ?nci Nur Salt?k Hülya Demir Doruk Engin ?zge Darka Ertun? Yakut Aky?n Nurten Ko?ak | 2003 | FEMS Immunology and Medical Microbiology2003，，3： | 1 |
| 17 | The effect of topical negative pressure on wound biofilms using an in vitro wound model显示文摘 | Ngo QD Vickery K Deva AK | | 0，，： | 1 |
| 18 | Cognitive a- bility and decline after early life stress exposure显示文摘 | Pesonen AK Eriksson JG Heinonen K | 2013 | Neurobiol Aging2013，34，6： | 1 |
| 19 | Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and aging 显示文摘 | Phadwal K Watson AS Simon AK | 2013 | Cell Mol Life Sci2013，70，1： | 1 |
| 20 | Patient satisfaction with the bone-anchored hearing aid: a 14-year experience 显示文摘 | Badran K Bunstone D Arya AK | 2006 | Otology & Neurotology2006，27，： | 1 |
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