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| 1 | Veno occlusive disease: Update on clinical management显示文摘Hepatic veno-occlusive disease is a clinical syndrome characterized by hepatomegaly, ascites, weight gain and jaundice, due to sinusoidal congestion which can be caused by alkaloid ingestion, but the most frequent cause is haematopoietic stem cell transplantation (STC) and is also seen after solid organ transplantation. The incidence of veno occlusive disease (VOD) after STC ranges from 0 to 70%, but is decreasing. Survival is good when VOD is a mild form, but when it is severe and associated with an increase of hepatic venous pressure gradient > 20 mmHg, and mortality is about 90%. Prevention remains the best therapeutic strategy, by using non-myeloablative conditioning regimens before STC. Prophylactic administration of ursodeoxycholic acid, being an antioxidant and antiapoptotic agent, can have some benefit in reducing overall mortality. Defibrotide, which has pro-fibrinolytic and antithrombotic properties, is the most effective therapy; decompression of the sinusoids by a transjugular intrahepatic portosystemic shunt (TIPS) can be tried, especially to treat VOD after liver transplantation and when multiorgan failure (MOF) is not present. Liver transplantation can be the last option, but can not be considered a standard rescue therapy, because usually the concomitant presence of multiorgan failure contraindicates this procedure. | M Senzolo G Germani E Cholongitas P Burra AK Burroughs | 2007 | World Journal of Gastroenterology2007，13，29： | 19 |
| 2 | Oxidative stress and nitric oxide in rats with alcohol-induced acute pancreatitis显示文摘AIM: Oxygen free radical mediated tissue damage is well established in pathogenesis of acute pancreatitis (AP).Whether nitric oxide (NO) plays a deleterious or a protective role is unknown. In alcohol-induced AP, we studied NO, lipooxidative damage and glutathione in pancreas, lung and circulation.METHODS: AP was induced in rats (n = 25) by injection of ethyl alcohol into the common biliary duct. A sham laparatomy was performed in controls (n = 15). After 24 h the animals were killed, blood and tissue sampling were done.RESULTS: Histopathologic evidence confirmed the development of AP. Marked changes were observed in the pulmonary tissue. Compared with controls, the AP group displayed higher values for NO metabolites in pancreas and lungs, and thiobarbituric acid reactive substances in circulation. Glutathione was lower in pancreas and in circulation. Glutathione and NO were positively correlated in pancreas and lungs of controls but negatively correlated in circulation of experimental group. In the experimental group, plasma thiobarbituric acid reactive substances were negatively correlated with pancreas thiobarbituric acid reactive substances but positively correlated with pancreas NO.CONCLUSION: NO increases in both pancreas and lungs in AP and NO contributes to the pathogenesis of AP under oxidative stress. | Gülnur Andican Remisa Gelisgen Ethem Unal Osman Baran Tortum Sergülen Dervisoglu Tayfun Karahasanoglu Gülden Bur(?)ak | 2005 | World Journal of Gastroenterology2005，11，15： | 18 |
| 3 | 中心和外周动脉脉搏波传导速度测量的重复性:社区动脉粥样硬化风险研究显示文摘通过脉搏波传导速度(pulsewavevelocity,PwV)检测动脉硬化程度是当前对高血压和心血管病风险评估和分层所日渐常用的方式。颈股动脉脉搏波传导速度(catroidfemoralarteryPWV,cfPWV)是一项公认的测定中心动脉硬化程度的方式。 | Meyer ML Tanaka H Palta P Patel MD Camplain R Couper D Cheng S Al Qunaibet A Poon AK Heiss G 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，5： | 6 |
| 4 | Production and characterization of ZnO nanoparticles and porous particles by ultrasonic spray pyrolysis using a zinc nitrate precursor显示文摘ZnO nanoparticles and porous particles were produced by an ultrasonic spray pyrolysis method using a zinc nitrate precursor at various temperatures under air atmosphere. The effects of reaction temperature on the size and morphology of ZnO particles were investi-gated. The samples were characterized by energy dispersive spectroscopy, X-ray diffraction, transmission electron microscopy, and scanning electron microscopy. ZnO particles were obtained in a hexagonal crystal structure and the crystallite shapes changed from spherical to hex-agonal by elevating the reaction temperature. The crystallite size grew by increasing the temperature, in spite of reducing the residence time in the heated zone. ZnO nanoparticles were obtained at the lowest reaction temperature and ZnO porous particles, formed by aggregation of ZnO nanoparticles due to effective sintering, were prepared at higher temperatures. The results showed that the properties of ZnO particles can be controlled by changing the reaction temperature in the ultrasonic spray pyrolysis method. | Burak Ebin Elif Arτg Burak zkal Sebahattin Gürmen | 2012 | International Journal of Minerals,Metallurgy and Materials2012，19，7： | 2 |
| 5 | 高度近视伴色觉缺失的家系分析(英文)显示文摘目的:评估高度近视伴色觉缺失患者的遗传学特征和临床表现方法:就同一家族4代42个成员中有8位患者给予了详细的眼科检查,Ishihara盘和FM100H试验检测患者有无红绿色觉缺失,全视野视网膜电图评价其视网膜功能。结果:患者8位均因高度近视视力下降,其中6例有红绿色觉缺失,眼底检查显示以弥漫性视网膜脉络膜萎缩为特征的近视改变。2例患者ERG检查出现视杆细胞的暗适应异常和视锥细胞的反应消失,根据家系,红绿色觉缺失属X连锁的隐性遗传。结论:在这个家族成员中,同时发生的高度近视和色觉缺失可能有共同的遗传学基础。 | Nimet nay Gündogan Ay■e Gül Koak Altinta■ Nezih Durmazlar Koray Gümüs Zerrin Yilmaz Kemal Ksemehmetoglu | 2007 | 国际眼科杂志2007，7，3： | 2 |
| 6 | Antioxidant and radical scavenging properties of curcumin显示文摘 | Tuba Ak ?lhami Gül?in | 2008 | Chemico-Biological Interactions2008，，1： | 2 |
| 7 | Viral hepatitis during prcgnancy 显示文摘 | Jaiswal SP Jain AK Naik G | 2001 | Int J Gynecol Obstet2001，72，2： | 1 |
| 8 | Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL Ⅻ/ECOG E2993 显示文摘 | Rowe JM Buck G Burnett AK | 2005 | Blood2005，106，： | 1 |
| 9 | The relation between plasma endothelin-1 levels and metabolic control,risk factors,treatment modalities,and diabetic microangiopathy in patients with Type 2 diabetes mellitus显示文摘 | Ak G Buyukberber S Sevinc A | 2001 | Diabetes Complications2001，15，3： | 1 |
| 10 | Seasonal variations in clinical and laboratory variables among chronic hemodialysis patients显示文摘 | Cheung AK Yan G Greene T | 2002 | J Am Soc Nephrol2002，13，： | 1 |
| 11 | O2-induced Na^+ channel expression is associated with NF-кB activation and blocked by superoxide scavenger 显示文摘 | Rafii B Tanswell AK Otulakowski G | 1998 | Am J Physio11998，275，41： | 1 |
| 12 | Stenting and sec ondary coiling of intracranial internal carotid artery aneurysm:technical case report 显示文摘 | Mericle RA Lanzino G Wakhloo AK | 1998 | Neurosurgery1998，43，5： | 1 |
| 13 | Bile acid abnormalities in cholestatic liver diseases显示文摘 | Salen G Batta AK | 1999 | Gastroenterol Clin North Am1999，28，2： | 1 |
| 14 | Insulin-like growth factor-1 induces phosphorylation of PI3K-Akt/PKB to potentiate proliferation of smooth muscle cells in human saphenous vein显示文摘 | Jia G Mitra AK Gangahar DM | 2010 | Experimental and Molecular Pathology2010，89，1： | 1 |
| 15 | Atherosclerotic cardiovascular disease risks in chronic hemodialysis patients显示文摘 | Cheung AK Samak M J Yah G | 2000 | Kidney Int2000，58，1： | 1 |
| 16 | Thioredoxin reductase 1 is upregulated in atherosclerotic plagues: specific induction of the promoter in human macrophages by oxidized low-density lipoproteins显示文摘 | Furman C Rundl6f AK Larigauderie G | 2004 | Free Radic Bilo Med2004，37，1： | 1 |
| 17 | Status of Vi gene, its expression and Salmonella pathogenicity island (SPI-7) in Salmonella typhi in India显示文摘 | Maurya P Gulati AK Nath G | 2010 | Southeast Asian J Trop Med Public Health2010，41，4： | 1 |
| 18 | Stereoselective synthesis of Jaspine B andits C2 epimer from gamer aldehyde 显示文摘 | JANA AK PANDA G | 2013 | Rsc Adv y2013，3，16： | 1 |
| 19 | Mechanisms and therapeutic applications of immune sumulatory CpG DNA显示文摘 | Kneg AM Yi AK Hartmann G | 1999 | Pharmacol Ther1999，84，2： | 1 |
| 20 | Randomised controlled trials of ursodeoxycholic - acid therapy for primary biliary cirrhosis : a meta-analysis 显示文摘 | GOULIS J LEANDRO G BURROUGHS AK | 1999 | Lancet1999，354，： | 1 |
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