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| 1 | Current scenario of traditional medicines in management of diabetic foot ulcers:A review显示文摘Diabetic foot infections and diabetic foot ulcers(DFU)cause significant suffering and are often recurring.DFU have three important pathogenic factors,namely,microangiopathy causing local tissue anoxia,neuropathy making the foot prone to injuries from trivial trauma,and local tissue hyperglycaemia favouring infection and delaying the wound healing.DFU have been the leading cause for non-traumatic amputations of part or whole of the limb.Western medicines focus mainly on euglycaemia,antimicrobials,debridement and wound cover with grafts,and off-loading techniques.Advances in euglycaemic control,foot care and footwear,systemic antimicrobial therapy,and overall health care access and delivery,have resulted in an overall decrease in amputations.However,the process of wound care after adequate debridement remains a major cost burden globally,especially in developing nations.This process revolves around two basic concerns regarding control/eradication of local infection and promotion of faster healing in a chronic DFU without recurrence.Wound modulation with various dressings and techniques are often a costly affair.Some aspects of the topical therapy with modern/Western medicines are frequently not addressed.Cost of and compliance to these therapies are important as both the wounds and their treatment are“chronic.”Naturally occurring agents/medications from traditional medicine systems have been used frequently in different cultures and nations,though without adequate clinical base/relevance.Traditional Chinese medicine involves restoring yin-yang balance,regulating the‘chi’,and promoting local blood circulation.Traditional medicines from India have been emphasizing on‘naturally’available products to control wound infection and promote all the aspects of wound healing.There is one more group of chemicals which are not pharmaceutical agents but can create acidic milieu in the wound to satisfy the above-mentioned basic concerns.Various natural and plant derived products(e.g.,honey,aloe vera,oils,and calendula)and maggots are also used for wound healing purposes.We believe that patients with a chronic wound are so tired physically,emotionally,and financially that they usually accept native traditional medicine which has the same cultural base,belief,and faith.Many of these products have never been tested in accordance to“evidence-based medicine.”There are usually case reports and experience-based reports about these products.Recently,there have been some trials(in vitro and in vivo)to verify the claims of usage of traditional medicines in management of DFU.Such studies show that these natural products enhance the healing process by controlling infection,stimulating granulation tissue,antimicrobial action,promoting fibroblastic activity and collagen deposition,etc.In this review,we attempt to study and analyse the available literature on results of topical traditional medicines,which are usually advocated in the management of DFU.An integrated and‘holistic’approach of both modern and traditional medicine may be more acceptable to the patient,cost effective,and easy to administer and monitor.This may also nevertheless lead to further improvement in quality of life and decrease in the rates of amputations for DFU. | Abhijit S Rayate Basavraj S Nagoba Sachin S Mumbre Hardi B Mavani Ajay M Gavkare Advait S Deshpande | 2023 | World Journal of Diabetes2023，14，1： | 3 |
| 2 | On calculation of fractal dimension of images 显示文摘 | AJAY K B JIBITESH M | 2001 | PatternRecognition Letters2001，22，67： | 1 |
| 3 | Duodental injuries: a review显示文摘 | Rao R I Ajai K M Mickel B A et aI | 2007 | Eur J Trauma Emerg Surg2007，3，2： | 1 |
| 4 | Flexible Ureteroscopy for Upper Ureteral Calculi in Chil dren显示文摘 | RAJENDRA B SHIVAGOUDA M AJAY K | 2011 | J Endourol2011，25，： | 1 |
| 5 | Thermal and catalytic upgrading of a biomass-derived oil in a dual reaction system显示文摘 | SRIMAT T S AJAY K D NARENDRA N B | 2000 | The Canadian Journal of Chemical Engineering2000，78，： | 1 |
| 6 | Oligopeptide-modified silicon nanowire arrays as multichannel metal ion sensors显示文摘 | Xin Y B Ajay A Yang K L | 2009 | Biosensors and Bioelectronics2009，24，11： | 1 |
| 7 | Effect of acute glycaemia index on clinical outcome after acute stroke显示文摘 | Ajay B Suki S Kate TR | 2002 | Cerebrolvascular Diseases2002，13，： | 1 |
| 8 | Effect of pant residues on the size of microbial biomass and nitrogen mineralization in soil incorporation of cowpea and wheat straw显示文摘 | Dharani D P Sukhpal C B Ajay M | 1992 | Soil Sci Plant Nutr1992，38，1： | 1 |
| 9 | Alteration of hemodynamics in aneurysm models by stenting: influence of stent porosity显示文摘 | BARUCH B ALFRED P AJAY K | 1997 | Annals of Biomedical Engineering1997，25，： | 1 |
| 10 | Specificinhibition of cyclooxygenase-2(COX2) expression by dietary curcumin in HT-29 human colon cancer cells 显示文摘 | Ajay C Richard B Dharam P C | 2001 | Cancer Lett2001，172，2： | 1 |
| 11 | 显示文摘 | Ajay P S Mrinal B | 2004 | Polym Eng Sci2004，44，10： | 1 |
| 12 | Synthesis of Gold, Silver and Their Alloy Nanoparticles Using Bovine Serum Albumin as Foaming and Stabilizing Agent显示文摘 | Ajay V S Bapurao M B Manasi K | 2005 | J Mater Chem2005，15，： | 1 |
| 13 | Deriving quantitative conclusions from microarray expression data显示文摘 | Olshen Adam B Jain Ajay N | 2002 | Bioinformaties2002，18，7： | 1 |
| 14 | Production of protein and cellulase by Aspergillus niger in solid state cul- ture显示文摘 | Ajay Singh Abidi A B Darmwal N S | 1989 | MIRCEN Journal1989，5，： | 1 |
| 15 | Inotropic contractilereserve and response to cardiac resynchronization therapy inpatients with markedly remodeled left ventricle 显示文摘 | FAROOQ A C AJAY S SRIPAL B | 2011 | J Am SocEchocardiogr2011，24，1： | 1 |
| 16 | Fournier Gangrene:Role of Imaging显示文摘 | Robin B Ajay K Robert A | 2009 | Radio Graphics2009，28，： | 1 |
| 17 | Flexible Ureteroseopy for Upper Ureteral Calculi in Children 显示文摘 | Nerli Rajendra B Patil Shivagouda M Guntaka Ajay Kumar | 2011 | Journal of Endourology2011，25，4： | 1 |
| 18 | Vegetation structure, niche width, niche overlap and types of competition in temperate grazingland of Garhwal Himalaya, India 显示文摘 | ANTHWAL S AJAY B BHATT A B | 2008 | Environmentalist2008，28，： | 1 |
| 19 | Preparation characterization and biodistribution of ultrafine chitosan nanoparticles显示文摘 | Tanina B Susmita M Ajay KS | 2002 | Int J Pharm2002，242，： | 1 |
| 20 | On calculation of fractal dimension of images显示文摘 | M Jibitesh | 2001 | Pattern Recognition Letters2001，22，： | 1 |
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