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| 1 | Insulin plus incretin:A glucose-lowering strategy for type 2-diabetes显示文摘There are many advantages of combining incretin therapy[glucagon-like peptide-1(GLP-1)receptor agonists and dipeptidyl peptidase-4(DPP-4)inhibitors]with insulin therapy as a glucose-lowering strategy in type2 diabetes.One important advantage is the complementary mode of the mechanistic action of incretin and insulin therapy.Another advantage is the reduction in risk of hypoglycemia and weight gain when adding incretin therapy to insulin.Several clinical trials have studied the addition of GLP-1 receptor agonists[exenatide BID(twice daily),lixisenatide,albiglutide]or DPP-4inhibitors(vildagliptin,sitagliptin,saxagliptin,alogliptin,linagliptin)to ongoing insulin therapy or adding insulin to ongoing therapy with a GLP-1 receptor agonist(liraglutide).These studies show improved glycemia in the presence of limited risk for hypoglycemia and weight gain with the combination of incretin therapy with insulin.This article reviews the background and clinical studies on this combination. | Bo Ahrén | 2014 | World Journal of Diabetes2014，5，1： | 5 |
| 2 | Vildagliptin Enhances Islet Responsiveness to Both Hyper- and Hypoglycemia in Patients with Type 2 Diabetes显示文摘 | Bo Ahrén Anja Schweizer Sylvie Dejager Beth E. Dunning Peter M. Nilsson Margaretha Persson James E. Foley | 2009 | The Journal of Clinical Endocrinology & Metabolism2009，，4： | 3 |
| 3 | Inhibition of Dipeptidyl Peptidase-4 Reduces Glycemia, Sustains Insulin Levels, and Reduces Glucagon Levels in Type 2 Diabetes显示文摘 | Bo Ahrén Mona Landin-Olsson Per-Anders Jansson Maria Svensson David Holmes Anja Schweizer | 2004 | The Journal of Clinical Endocrinology & Metabolism2004，，5： | 2 |
| 4 | 甲状腺内的调节肽显示文摘甲状腺滤泡细胞合成和分泌甲状腺激素(T_4和 T_3),这些细胞分泌活动的主要调节者是促甲状腺激素(TSH)。另外,甲状腺激素的分泌还受甲状腺内肽的影响。这些肽可能在甲状腺内肽能神经、腺泡旁 C 细胞内或在腺泡细胞内产生。 | Ahre'n B 王启发 周健秋 | 1992 | 国外医学(内分泌学分册)1992，12，1： | 2 |
| 5 | A Mathematical Model for Dynamic Simulation of Anaerobic Digestion of Complex Substrates: Focusing on Ammonia Inhibition显示文摘 | ANGELIDAKI I ELLEGAARD L AHRING B K | 1993 | Biotechnology and Bioengineering1993，42，2： | 1 |
| 6 | Characterization of degradation products from alkaline wet oxidation of wheat straw显示文摘 | Klinke H B Ahring B K Schmidt A S | 2002 | Bioresource Technology2002，82，1： | 1 |
| 7 | Leptin is associated with increased risk of myocardial infarction 显示文摘 | Serberg S Ahr B Jansson JH | 1999 | J Interm Med1999，246，4： | 1 |
| 8 | Inhibition of dipeptidyl peptidase-4 augments insulin secretion in response to exogenously administered glucagon-like peptide-1, glucose-dependent insulinotropie polypeptide, pituitary adenylate eyelase-activating polypeptide, and gastrin-releasing peptide in mice显示文摘 | Ahrén B Hughes TE | 2005 | Endocrinology2005，146，4： | 1 |
| 9 | Quantification of syntrophic fatty acid-beta-oxidizing bacteria in a mesophilic biogas reactor by oligonucleotide probe hybridization 显示文摘 | Hansen KH Ahring BK Raskin L | 1999 | Appl Environ Microbiol1999，65，11： | 1 |
| 10 | Pharmacokinetics of nisoldipine in renal dysfunction显示文摘 | Valcke Y Dammekens H De Vriese G Ahr G Schurgers M | 1988 | Eur J Clin Pharmacol1988，34，2： | 1 |
| 11 | Anaerobic digestion of swine manure:inhibition by ammonia显示文摘 | Hansen K H Angelidaki I Ahring B K | 1998 | Water Research1998，32，1： | 1 |
| 12 | Anaerobic granular sludge and biofilm reactors显示文摘 | Skiadas I V Gavala H N Schmidt J E Ahring B K | 2003 | Advances in Biochemical Engineering/ Biotechnology2003，82，： | 1 |
| 13 | pH dependency and desensitization kinetics of heterologously expressed combinations of acid-sensing ion channel subunits显示文摘 | Hesselager M Timmermann D B Ahring P K | 2004 | J Biol Chem2004，279，11： | 1 |
| 14 | Anaerobic digestion of the organic fraction of municipal solid waste: Influence of co- digestion with manure 显示文摘 | Hartmann H Ahring BK | 2005 | Water Research2005，39，8： | 1 |
| 15 | Rat cortical neuron cultures: an in vitro model for differentiating mechanisms of chemically induced neurotoxicity显示文摘 | Schmuck G Ahr I-IJ Schluter G | 2000 | In Vitr Mol Toxieol2000，13，： | 1 |
| 16 | Anaerobic digestion of swine manure: inhibition by ammonia 显示文摘 | Hansen K H Angelidaki I Ahring B K | 1998 | Water Res1998，32，： | 1 |
| 17 | Toxicity of di-(2-ethylhexyl) phthalate on the anaerobic digestion of wastewater sludge显示文摘 | IRANPOUR R AHRING B K | 2003 | Water Research2003，37，： | 1 |
| 18 | Granular slaudge Formation in upflow anaerobic sludge blanket(UA SB)reactors显示文摘 | Schmidt J E Ahring B R | 1996 | Biotechnology and Bioengiheering1996，，49： | 1 |
| 19 | Role of the intracellular domains of CXCR4 in SDF-l-mediated signaling 显示文摘 | Roland J Murphy BJ Ahr B | 2003 | Blood2003，101，2： | 1 |
| 20 | Separation efficiency and particle size distribution in relation to manure type and storage conditions 显示文摘 | Moller H B Sommer S G Ahring B K | 2002 | Bioresource Technology2002，85，： | 1 |
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