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| 1 | Role of calcium in polycystic kidney disease:From signaling to pathology显示文摘Autosomal dominant polycystic kidney disease(ADPKD) is the most common inherited monogenic kidney disease. Characterized by the development and growth of cysts that cause progressive kidney enlargement, it ultimately leads to end-stage renal disease. Approximately 85% of ADPKD cases are caused by mutations in the PKD1 gene, while mutations in the PKD2 gene account for the remaining 15% of cases. The PKD1 gene encodes for polycystin-1(PC1), a large multi-functional membrane receptor protein able to regulate ion channel complexes, whereas polycystin-2(PC2), encoded by the PKD2 gene, is an integral membrane protein that functions as a calcium-permeable cation channel, located mainly in the endoplasmic reticulum(ER). In the primary cilia of the epithelial cells, PC1 interacts with PC2 to form a polycystin complex that acts as a mechanosensor, regulating signaling pathways involved in the differentiation of kidney tubular epithelial cells. Despite progress in understanding the function of these proteins, the molecular mechanisms associated with the pathogenesis of ADPKD remain unclear. In this review we discuss how an imbalance between functional PC1 and PC2 proteins may disrupt calcium channel activities in the cilium, plasma membrane and ER, thereby altering intracellular calcium signaling and leading to the aberrant cell proliferation and apoptosis associated with the development and growth of renal cysts. Research in this field could lead to the discovery of new molecules able to rebalance intracellular calcium, thereby normalizing cell proliferation and reducing kidney cyst progression. | Alessandra Mangolini Lucia de Stephanis Gianluca Aguiari | 2016 | World Journal of Nephrology2016，5，1： | 5 |
| 2 | High glucose induces adipogenic differentiation of muscle-derived stem cells显示文摘 | Aguiari P Leo S Zavan B | 2008 | Proc Natl Acad Sci2008，105，4： | 1 |
| 3 | Polycystin-1 regu- lates amphiregulin expression through CREB and AP1 sig- nalling: implications in ADPKD cell proliferation 显示文摘 | Aguiari G Bizzarri F Bonon A | 2012 | J Mol Med2012，90，： | 1 |
| 4 | High glucose induc- es adipogenic differentiation of muscle-derived stem cells显示文摘 | AGUIARI P LEO S ZAVAN B | 2008 | Proc Natl Acad Sci USA2008，105，4： | 1 |
| 5 | Effects of a hydroxyapatite-based biomaterial on gene expression in osteoblast-like cells显示文摘 | Sibilla P Sereni A Aguiari G | 2006 | J Dent Res2006，85，4： | 1 |
| 6 | Identification of Meat Species显示文摘 | AGUIARI D PARISI E | 1984 | Elsevier Apple Sci Publ London P1984，，： | 1 |
| 7 | Dinucleotide repeat Polymorphismin the human estrogen(ESR) gene 显示文摘 | Del Senno L Aguiari GL Piva R | 1992 | J Hum MoI Genet1992，1，： | 1 |
| 8 | High glucose induces adipogenic differentiation of muscle-derived stem cells显示文摘 | Aguiari P Leo S Zavan B | 2008 | PNAS2008，105，： | 1 |
| 9 | Effects of a hyd- roxyapatite-based biomaterlal on gene expression in osteo- blast-like cells显示文摘 | SibiUa P Sereni A Aguiari G | 2006 | J Dent Res2006，85，： | 1 |
| 10 | Effects of a hydroxyapatite-based biomaterial on gene expression in osteoblast-like cells显示文摘 | Sibilla P Sereni A Aguiari G Banzi M Manzati E Mischiati C Trombelli L del Senno L | | 0，，： | 1 |
| 11 | The cytoplasmic C-terminus of polycystin-1 increases cell proliferation in kidney epithelial cells through serum-activated and Ca (2 +)-dependent pathway(s)显示文摘 | Manzati E Aguiari G Banzi M | 2005 | Exp Cell Res2005，304，2： | 1 |
| 12 | Effects of a hydroxyapa- rite-based biomaterial on gene expression in osteoblast-like cells显示文摘 | Sibilla P Sereni A Aguiari G | 2006 | J Dent Res2006，85，4： | 1 |
| 13 | Effects of a hydroxyapatitebased biomaterial on gene expression in osteoblast-like cells显示文摘 | Sibilla P Sereni A Aguiari G | 2006 | J Dent Res2006，85，4： | 1 |
| 14 | High glucose induces adipogenic differentiation of muscle-derived stem cells 显示文摘 | Aguiari P Leo S Zavan B | 2008 | Proc Natl Acad Sci2008，105，： | 1 |
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