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| 1 | Amphiphilic dendronized homopolymers显示文摘A series of second generation of amphiphilic dendronized homopolymers are efficiently synthesized,and their thermoresponsiveness in aqueous solutions and secondary structures in methanol solutions are described.These polymers are constructed in each repeat unit with various generations of hydrophobic 4-aminoproline and hydrophilic oligoethylene glycol (OEG)-based dendrons,and their over-all hydrophilicity is tuned by varying these dendron generations.Polymers with or without the first generation of proline dendron show good water solubility at room temperature,but exhibit typical thermoresponsive behaviors at elevated temperatures as characterized by turbidity measurements using UV-vis spectroscopy,while the polymer with the secondary generation of proline dendron is not soluble in water.All polymers show ordered secondary structures as evidenced by the optical rotation and circular dichroism experiments.Finally,assembly of these amphiphilic homopolymers into porous films via breath figure (BF) technique is described,and polymer structures are found to show significant influence on the morphology of porous film. | LI Wen 1 & ZHANG AFang 1,2 1 Institute of Polymers,Department of Materials,ETH Zurich,Wolfgang-Pauli-Str.10,8093 Zurich,Switzerland 2 Department of Polymer Materials,College of Materials Science and Engineering,Shanghai University,Shanghai 201800,China | 2010 | Science China Chemistry2010，53，12： | 2 |
| 2 | Thermoresponsive dendronized copolymers for protein recognitions based on biotin-avidin interaction显示文摘Thermoresponsive biotinylated dendronized copolymers carrying dendritic oligoethylene glycol(OEG)pendants were prepared via free radical polymerization,and their protein recognitions based on biotin-avidin interaction investigated.Both first(PG1) and second generation(PG2) dendronized copolymers were designed to examine possible thickness effects on the interaction between biotin and avidin.Inherited from the outstanding thermoresponsive properties from OEG dendrons,these biotinylated cylindrical copolymers show characteristic thermoresponsive behavior which provides an envelope to capture avidin through switching temperatures above or below their phase transition temperatures(T_(cp)s).Thus,the recognition of polymer-supported biotin with avidin was investigated with UV/vis spectroscopy and dynamic laser light scattering.In contrast to the case for PG1,the increased thickness for copolymer PG2 hinders partially and inhibits the recognition of biotin moieties with avidin either below or above its T_(cp).This demonstrates the significant architecture effects from dendronized polymers on the biotin moieties to shift onto periphery of the collapsed aggregates,which should be a prerequisite for protein recognition.These kinds of novel thermoresponsive copolymers may pave a way for the interesting biological applications in areas such as reversible activity control of enzyme or proteins,and for controlled delivery of drugs or genes. | Chunhua Zhou Mona A.Abdel-Rahman Wen Li Kun Liu Afang Zhang | 2017 | Chinese Chemical Letters2017，28，4： | 2 |
| 3 | Low toxic, thermoresponsive dendrimers based on oligoethylene glycols with sharp and fully reversible phase transitions 显示文摘 | Li Wen Zhang Afang Chen Yong | 2008 | Chem Commun (Camb)2008，45，： | 1 |
| 4 | Strict Size Specificity in Colorimetric Anion Detection Based on Poly (phenylacetylene) Receptor Bearing Second Generation LysineDendrons 显示文摘 | Ryosuke Sakai Naoya Sakai Toshifumi Satoh Wen Li Afang Zhang Toyoji Kakuchi | 2011 | Macromolecules2011，44，： | 1 |
| 5 | Synthesis of Helical Poly(phenylacetylene)s Carrying Dendritic Pendants with Varied Branching Densities Through Polymerization in Different Solvents显示文摘Helical poly(phenylacetylene)s(PPAs)have received extensive attention because of their features in dynamic chirality and promising applications.Therefore,understanding relationship among the polymer molecular structures,polymerization conditions and tunability of their chirality is of key scientific value.Recently,we developed a novel class of dendronized PPAs carrying 3-fold dendritic oligo(ethylene glycols)(OEGs)via alanine linkage,and found that these bulky polymers exhibited tunable helical conformations through thermally-mediated dehydration and aggregation.Herein,we report on synthesis of a homologous series of dendronized PPAs that carry 2-fold,3-fold or 6-fold dendritic OEG pendants,and focus on effects of molecular topological structures,peripheral units and polymerization solvents on the thermoresponsiveness and their conformation switching behaviors.Effects of branching density and peripheral units(ethoxyl or methoxyl)of the dendritic OEG pendants were examined,and found to play a decisive role on the helical conformation and thermoresponsiveness of these dendronized PPAs due to their different bulkiness and overall hydrophilicity.In addition,different polymerization solvents were checked for their possible influence on the polymerization,thermoresponsive behavior and the chirality of the resulting polymers.For polymerization in selective solvents like water or methanol,the obtained dendronized PPAs exhibited weak thermal transitions,while polymerization in non-selective solvent like THF furnished PPAs with characteristic thermoresponsive behavior,indicating that solvents were involved in the process of polymerization of the dendronized macromonomers.More interestingly,different chiralities of the PPAs through polymerization in various solvents were retained,irrelevant to the purification process and solvents treatments.This work suggests that the topological structures together with polymerization solvents can modulate the thermoresponsive behavior and helical conformation of the dendronized PPAs. | Zhen-Zhen Sun Yan-Ning Zhang Hao-Yu Qiu Xue-Ting Lu Liang-Xuan Ren Le-Fei Shen Wen Li Afang Zhang | 2023 | Chinese Journal of Polymer Science2023，41，10： | 0 |
| 6 | Thermoresponsive Nanogels from Dendronized Copolymers for Complexation,Protection and Release of Nucleic Acids显示文摘A series of thermoresponsive cationic dendronized copolymers and their corresponding nano gels containing den dritic oligoethylene glycol(OEG)units and guanidine groups were prepared,and their complexation,protect!on,and release of nucleic acids were investigated.The dendritic OEGs endow these copolymer materials with good biocompatibility and characteristic thermoresponsiveness,while cationic guanidine groups can efficiently bind with the nucleic acids.The dendritic topology also affords the copolymers specific shielding effect which plays an essential role in protecting the activity of nucleic acids.At room temperature,dendronized copolymers and the corresponding nanogels could efficiently capture and condense the nucleic acids,while above their cloud points(Tcps),more than 75%of siRNA could be released in 1 h triggered by ATP.More importantly,the copolymer showed protective capability to siRNA,while nano gels exhibit even better protection when compared to the copolymers due to the synergetic effect from the three-dimensional cross-linked network and high density of dendritic units in vicinity.This kind of smart dendr on ized copolymer nano gels form a no vel class of scaffolds as promisi ng materials for biomedical applicatio ns. | Yi Yao Jian-Hui Wu Shi-Jie Cao Bi-Yi Xu Jia-Tao Yan Di Wu Wen Li Afang Zhang | 2020 | Chinese Journal of Polymer Science2020，38，11： | 0 |
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