2篇
您的检索式：作者名="Adrian T.TING"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | B细胞成熟抗原BCMA在细胞内诱导NF-κB的活化显示文摘目的 :研究细胞表面B细胞成熟抗原 (B cellmatu rationantigen ,BCMA)在B细胞激活因子刺激下 ,对转录因子NF κB是否具有激活作用 .方法 :采用电转移基因转染和卤化钙基因转染方法 ,将BCMA和C末端缺失 80个氨基酸残基的BCMA基因 (BCMAΔC80 )分别转染 3T8细胞及kbgfp细胞 ,观察与NF κB启动子下游的报告基因表达水平的变化 .结果 :BCMA在 3T8细胞中经BAFF激活后可上调报告质粒中CD14基因的表达 ,而C末端缺失 80个氨基酸残基的突变BCMA(BCMAΔC80 )则不具备此功能 .同时在另一报告细胞系kbgfp中亦观察到类似作用 .结论 :细胞表面的BCMA在被B细胞激活因子刺激后 ,可引起NF κB的活化 ,这一作用依赖于BCMA的C末端的 80个氨基酸残基 . | 杨敏 刘娜 Adrian T.TING | 2003 | 第四军医大学学报2003，24，19： | 1 |
| 2 | IFN-γ^(+) cytotoxic CD4^(+) T lymphocytes are involved in thepathogenesis of colitis induced by IL-23 and the foodcolorant Red 40显示文摘The food colorant Red 40 is an environmental risk factor for colitis development in mice with increased expression of interleukin(IL)-23.This immune response is mediated by CD4^(+)T cells,but mechanistic insights into how these CD4^(+)T cells trigger andperpetuate colitis have remained elusive.Here,using single-cell transcriptomic analysis,we found that several CD4^(+)T-cell subsetsare present in the intestines of colitic mice,including an interferon(IFN)-γ-producing subset.In vivo challenge of primed mice withRed 40 promoted rapid activation of CD4^(+)T cells and caused marked intestinal epithelial cell(IEC)apoptosis that was attenuated bydepletion of CD4^(+)cells and blockade of IFN-γ.Ex vivo experiments showed that intestinal CD4^(+)T cells from colitic mice directlypromoted apoptosis of IECs and intestinal enteroids.CD4^(+)T cell-mediated cytotoxicity was contact-dependent and required FasL,which promoted caspase-dependent cell death in target IECs.Genetic ablation of IFN-γconstrained IL-23-and Red 40-inducedcolitis development,and blockade of IFN-γinhibited epithelial cell death in vivo.These results advance the understanding of themechanisms regulating colitis development caused by IL-23 and food colorants and identify IFN-γ^(+)cytotoxic CD4^(+)T cells as a newpotential therapeutic target for colitis. | Lili Chen Zhengxiang He Bernardo S.Reis Jesse D.Gelles Jerry Edward Chipuk Adrian T.Ting Julie A.Spicer Joseph A.Trapani Glaucia C.Furtado Sergio A.Lira | 2022 | Cellular & Molecular Immunology2022，19，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员