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| 1 | Alteration in the expression of microRNA-21 regulated target genes:Role in breast cancer显示文摘Breast cancer,also recognized as the principal cause of cancer-related deaths among women,is the second most familiar and prevalent form of cancer.New diagnostic and prognostic biomarkers that are highly specific are urgently needed for its early prognosis.MicroRNAs(miRNAs),a class of non-coding RNAs,are known to control the biological processes involving transcription,post-transcriptional and covalent modifications,splicing,translation,cell differentiation,proliferation,apoptosis,cancer progression,and invasion.Any dysregulation in miRNA expression,demonstrating their oncogenic and tumor-suppressive functions,contributes to cancer progression.MicroRNA-21(miR-21),an‘onco-miR’in breast cancer,is involved in tumor progression and metastasis by suppressing the activity of the target gene via its interaction with the 3’UTR of the target gene.The upregulation of miR-21 is observed in many instances of breast cancer.Our review aims to summarize the current understanding of miR-21 in the regulation of important cellular functions via regulation of its target genes.We discuss its biosynthesis,oncogenic function in breast cancer,and different methods used for its detection.This will increase the current understanding of the role of miR-21 in breast cancer tumorigenesis,which will offer a perception of using miR-21 as an early detection molecular prognostic and diagnostic biomarker and as a therapeutic target in breast cancer care. | PRIYANKA THAKUR REENA V.SAINI ANIL K.CHHILLAR NEERAJ K.SAINI VIJAY KUMAR THAKUR SAMARJEET SINGH SIWAL ADESH K.SAINI | 2022 | BIOCELL2022，46，2： | 1 |
| 2 | Hardware Chip Performance of CORDIC Based OFDM Transceiver for Wireless Communication显示文摘The fourth-generation(4G)and fifth-generation(5G)wireless communication systems use the orthogonal frequency division multiplexing(OFDM)modulation techniques and subcarrier allocations.The OFDM modulator and demodulator have inverse fast Fourier transform(IFFT)and fast Fourier transform(FFT)respectively.The biggest challenge in IFFT/FFT processor is the computation of imaginary and real values.CORDIC has been proved one of the best rotation algorithms for logarithmic,trigonometric,and complex calculations.The proposed work focuses on the OFDM transceiver hardware chip implementation,in which 8-point to 1024-point IFFT and FFT are used to compute the operations in transmitter and receiver respectively.The coordinate rotation digital computer(CORDIC)algorithm has read-only memory(ROM)-based architecture to store FFT twiddle factors and their angle generators.The address generation unit is required to fetch the data and write the results into the memory in the appropriate sequence.CORDIC provides low memory,delay,and optimized hardware on the field-programmable gate array(FPGA)in comparison to normal FFT architecture for the OFDM system.The comparative performance of the FFT and CORDICFFT based OFDM transceiver chip is estimated using FPGA parameters:slices,flip-flops,lookup table(LUTs),frequency,power,and delay.The design is developed using integrated synthesis environment(ISE)Xilinx version 14.7 software,synthesized using very-high-speed integrated circuit hardware description language(VHDL),and tested on Virtex-5 FPGA. | Amit Kumar Adesh Kumar Geetam Singh Tomar | 2022 | Computer Systems Science & Engineering2022，40，2： | 1 |
| 3 | Design and Simulation of Ring Network-on-Chip for Different Configured Nodes显示文摘The network-on-chip(NoC)technology is frequently referred to as a front-end solution to a back-end problem.The physical substructure that transfers data on the chip and ensures the quality of service begins to collapse when the size of semiconductor transistor dimensions shrinks and growing numbers of intellectual property(IP)blocks working together are integrated into a chip.The system on chip(SoC)architecture of today is so complex that not utilizing the crossbar and traditional hierarchical bus architecture.NoC connectivity reduces the amount of hardware required for routing and functions,allowing SoCs with NoC interconnect fabrics to operate at higher frequencies.Ring(Octagons)is a direct NoC that is specifically used to solve the scalability problem by expanding each node in the shape of an octagon.This paper discusses the ring NoC design concept and its simulation in Xilinx ISE 14.7,as well as the communication of functional nodes.For the field-programmable gate array(FPGA)synthesis,the performance of NoC is evaluated in terms of hardware and timing parameters.The design allows 64 to 256 node communication in a single chip with‘N’bit data transfer in the ring NoC.The performance of the NoC is evaluated with variable nodes from 2 to 256 in Digilent manufactured Virtex-5 FPGA hardware. | Arpit Jain Rakesh Kumar Dwivedi Hammam Alshazly Adesh Kumar Sami Bourouis Manjit Kaur | 2022 | Computers, Materials & Continua2022，，5： | 0 |
| 4 | Performance Analysis of AODV Routing forWireless Sensor Network in FPGA Hardware显示文摘Wireless sensor network(WSN)is a group of interconnected sensor nodes that work wirelessly to capture the information of surroundings.The routing of the network is a challenging task.The routing of WSN is classified as proactive,reactive,and hybrid.Adhoc on-demand distance vector(AODV)routing is an example of reactive routing based on the demand route formations among different nodes in the network.The research article emphasizes the design and simulation of the AODV routing hardware chip using very-high-speed integrated circuit hardware description language(VHDL)programming in Xilinx integrated synthesis environment(ISE)14.7 software.The performance of the chip is studied based on the field-programmable gate array(FPGA)hardware parameters such as slices,lookup table(LUTs),input/output block(IOB),flipflops,and memory for the different configurations of the network(N=10,20….100).The delay and frequency are also estimated on the Virtex-5 FPGA.The performance of the WSN with AODV routing is also analyzed based on the packet delivery ratio,throughput,delay,and control overhead.The simulation test cases verified the 8-bit,64-bit,and 128-bit data communication within the nodes. | Namit Gupta Kunwar Singh Vaisla Arpit Jain Adesh Kumar Rajeev Kumar | 2022 | Computer Systems Science & Engineering2022，40，3： | 0 |
| 5 | Applications of artificial intelligence in power systemoperation, control and planning: a review显示文摘As different artificial intelligence(AI)techniques continue to evolve,power systems are undergoing significant technological changes with the primary goal of reducing computational time,decreasing utility and consumer costs and ensuring the reliable operation of an electrical power system.AI techniques compute large amounts of data at a faster speed than numerical optimization methods with higher processing speeds.With these features,AI techniques can further automate and increase the performance of power sys-tems.This paper presents a comprehensive overview of diverse AI techniques that can be applied in power system operation,control and planning,aiming to facilitate their various applications.We explained how AI can be used to resolve system frequency changes,maintain the voltage profile to minimize transmission losses,reduce the fault rate and minimize reactive current in distributed sys-tems to increase the power factor and improve the voltage profile. | Utkarsh Pandey Anshumaan Pathak Adesh Kumar Surajit Mondal | 2023 | Clean Energy2023，7，6： | 0 |
| 6 | Assessment of colistin resistance in Gram negative bacteria from clinical samples in resource-limited settings显示文摘Objective:To find a proper method to assess colistin resistance in multidrug resistant Gram negative bacteria(MDR-GNB)on a routine basis in resource limited settings.Methods:Clinical samples were processed.MDR-GNB were identified and were examined for colistin resistance by colistin broth elution method,colistin agar method,and colistin disk elution screening method.Broth microdilution method was used the gold standard.Results:A total of 10235 clinical samples were processed,in which 857(8.4%)MDR-GNB were identified.The very significant errors,categorical agreement,major errors,positive predictive values,negative predictive values,specificity and sensitivity of all the phenotypic methods were 5.5%,0%,94.4%,100%,99.6%,100%and 94.4%,respectively for the detection of colistin resistance.The colistin elution screening method was cheap and easy to perform with similar results to broth microdilution method.Conclusions:All the evaluation methods for colistin resistance showed similar results.So the laboratories can choose any method for detection of colistin resistance.However,we recommend colistin disk elution screening method because,it is easy and cheap and can be performed in limited resources. | Shubham Chauhan Narinder Kaur Adesh K.Saini Jyoti Chauhan Harit Kumar | 2022 | Asian Pacific Journal of Tropical Medicine2022，15，8： | 0 |
| 7 | Antimicrobial Materials: New Strategies to Tackle Various Pandemics显示文摘Coronaviruses are responsible for a developing budgetary,human and fatality trouble,as the causative factor of infections,for example,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).It has been well recognized that SARS-CoV-2 may survive under severe atmosphere circumstances.Hence,efficient containment approaches,for example,sanitizing,are crucial.Commonly,living compounds contribute a substance of chemical heterogeneity,with antiviral movement,and therefore can have efficacy as therapeutic tools toward coronavirus diseases.Here,in this review article,we have described the antimicrobialbased materials,which can be used to inhibit the spreading of the COVID-19.We have categorized these materials in three sections;(i)antimicrobial wall paint,(ii)antimicrobial papers and(iii)antimicrobial materials surface coating to be utilized as the antimicrobial-based materials for controlling the COVID-19.In the last section,we have given the concluding remarks with prospects in this area. | Samarjeet Singh Siwal Qibo Zhang Adesh Kumar Saini Vijay Kumar Thakur | 2020 | Journal of Renewable Materials2020，8，12： | 0 |
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