2篇
您的检索式：作者名="Ademar Lopes"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 一氧化氮合成酶、环氧化酶-2、硝基酪氨酸及血管生成与软骨肉瘤预后的相关性研究显示文摘背景:免疫组织化学标记物有助于肿瘤诊断及预后评估。通过对硝基酪氨酸分析及采用一氧化氮合成酶1(NOS1)、一氧化氮合成酶2(NOS2)、一氧化氮合成酶3(NOS3)检测分析可了解一氧化氮(NO)与肿瘤的相关性。NO与超氧阴离子反应产生的过氧亚硝酸对基因有毒性作用,过氧亚硝酸传递一个硝基基团到酪氨酸的苯环上形成硝基酪氨酸。细胞内硝基酪氨酸的积累说明过氧亚硝酸持续生成。NO刺激所生成的环氧化酶-2(COX-2)与肿瘤内新生血管水平相关,研究表明新生血管影响肿瘤预后,免疫组化标记CD34可表示微血管生成,从而被用于预测肿瘤预后。本研究检测上述标记物在软骨肉瘤中的表达并分析与软骨肉瘤分级和预后的相关性。方法:101例软骨肉瘤患者肿瘤组织样本采用甲醛固定,组织样本采用免疫组织化学染色,指标为:NOS1、NOS2、NOS3、COX-2、硝基酪氨酸和CD34。5例正常软骨样本作为对照。研究分析患者特征、手术变量、肿瘤分级与这些指标的相关性。使用Kaplan—Meier多变量统计学方法分析生存曲线及生存率。结果:硝基酪氨酸、COX-2和CD34与组织学分级有明显相关性(p=0.022,p=0.014,p=0.028),但与总体预后无相关性(p=0.064,p=0.143,p=0.581)。NOS2阳性表达常预示较高的局部复发率(p=0.038)。NOS1、NOS2阳性表达预示较低的生存率(p=0.007,p〈0.001)。通过多变量分析处理,NOS2的表达被证实可作为局部复发率的独立预后判断因素;NOS1、NOS2的表达作为因变量,它们单独或复合阳性表达常与较低的总生存率有关(p=0.046,p=0.004)[危险率,3.17(95%置信区间,1.0-9.8)和5.58(95%置信区间,1.7-18.0)]。 | Suely Akiko Nakagawa Ademar Lopes Andre Lopes de Carvalho Benedito Mauro Rossi Isabela Werneck da Cunha Fernando Augusto Soares Wu Tu Chung Luciola Assuncao 刘沛宜(译) 张伟滨(译) | 2010 | 中华骨科杂志2010，30，12： | 0 |
| 2 | Performance of the Multiprofessional Team in Cytoreductive Surgeries with Intraperitoneal Hyperthermic Chemotherapy:Experience Reporting显示文摘Purpose:This study aims at reporting the experience of a cancer hospital’s multiprofessional team with surgery patients in performing cytoreductive surgeries associated with hyperthermic intraperitoneal chemotherapy.Methods:It is a reporting about the experience of the multiprofessional team at AC Camargo Cancer Center’s surgery center,which operates in cytoreductive surgeries with hyperthermic intraperitoneal chemotherapy,thus guaranteeing the surgery patient’s safety.Results:No safety report for the surgery patient subjected to intraperitoneal hypothermic chemotherapy was found in the literature.Therefore,the surgery center’s multiprofessional team’s practice was based on standards for manipulating chemotherapeutic agents and for safely administering medication.A checklist was elaborated for cytoreductive surgeries with hyperthermic intraperitoneal chemotherapy based on the surgery patient safety protocol and the institution’s multiprofessional team’s experience.Conclusions:From the multiprofessional team’s experiences in cytoreductive surgeries with hyperthermic intraperitoneal chemotherapy,the importance of elaborating a checklist to promote the quality of assistance and guarantee patient safety during the entire intraoperative phase became evident. | Cecília da Silva Angelo(RN) Ademar Lopes(PhD) Catharina Ferreira de Meira Pachioni(MSc) Eduardo Henrique Giroud Joaquim(MSc) Samuel Aguiar Junior(PhD) Gustavo Cardoso Guimaraes(PhD) Glauco Baiocchi Neto(PhD) Felipe JoséFernandez Coimbra(PhD) Isabel Miranda Bonfim(MSc) Rita de Cassia Burgos de Oliveira(PhD) Tailine Ligia Tadini(RN) | 2018 | Journal of Pharmacy and Pharmacology2018，6，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员