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| 1 | Relationship between sonographically measured median nerve cross-sectional area and presence of peripheral neuropathy in diabetic subjects显示文摘BACKGROUND Neuropathy is a common complication of diabetes mellitus resulting from direct damage by hyperglycemia to the nerves and/or ischemia by microvascular injury to the endoneurial vessels which supply the nerves. Median nerve is one of the peripheral nerves commonly affected in diabetic neuropathy. The median nerve size has been studied in non-Nigerian diabetic populations. In attempt to contribute to existing literature, a study in a Nigerian population is needed.AIM To evaluate the cross-sectional area(CSA) of the median nerve using B-mode ultrasonography(USS) and the presence of peripheral neuropathy(PN) in a cohort of adult diabetic Nigerians.METHODS Demographic and anthropometric data of 85 adult diabetes mellitus(DM) and 85 age-and sex-matched apparently healthy control(HC) subjects were taken. A complete physical examination was performed on all study subjects to determine the presence of PN and modified Michigan Neuropathy Screening Instrument(MNSI) was used to grade its severity. Venous blood was taken from the study subjects for fasting lipid profile(FLP), fasting blood glucose(FBG) and glycated haemoglobin(HbA1 c) while their MN CSA was evaluated at a point 5 cm proximal to(5 cmCATL) and at the carpal tunnel(CATL) by high-resolution Bmode USS. Data was analysed using SPSS version 22.RESULTS The mean MN CSA was significantly thicker in DM subjects compared to the HC at 5 cmCATL(P < 0.01) and at the CATL(P < 0.01) on both sides. The presence of diabetic peripheral neuropathy(DPN) further increased the MN CSA at the CATL(P < 0.05) but not at 5 cmCATL(P > 0.05). However, the severity of DPN had no additional effect on MN CSA 5 cm proximal to and at the CATL. There was no significant association between MN CSA and duration of DM and glycemic control.CONCLUSION Thickening of the MN CSA at 5 cmCATL and CATL is seen in DM. Presence of DPN is associated with worse thickening of the MN CSA at the CATL but not at5 cmCATL. Severity of DPN, duration of DM, and glycemic control had no additional effect on the MN CSA. | Fredrick ANDrew Attah Christianah Mopelola Asaleye Adeleye Dorcas Omisore Babatope Ayodeji Kolawole Adeniyi Sunday Aderibigbe Mathew Alo | 2019 | World Journal of Diabetes2019，10，1： | 8 |
| 2 | Burden of diabetic foot ulcer in Nigeria: Current evidence from the multicenter evaluation of diabetic foot ulcer in Nigeria显示文摘BACKGROUND Nigeria bears the greatest burden of diabetes prevalence in Sub-Saharan Africa. Diabetic foot ulcer (DFU) is a serious and potentially life-threatening complication of diabetes. Significant improvements in diabetic foot incidence and outcomes have been recorded in many Western countries in the past decade. However, the current burden of DFU in Nigeria is largely unknown. AIM To evaluate the patients’ profile, ulcer characteristics, associated co-morbidities and outcome of patients with DFU in Nigeria. METHODS Multicenter evaluation of diabetic foot ulcer in Nigeria was a one year multicenter observational study of patients hospitalized for DFU in six tertiary health institutions in Nigeria from March 2016 to March 2017. Demographic and diabetes information, ulcer characteristics and associated co-morbidities were assessed. Relevant laboratory and imaging studies were performed. All patients received appropriate multi-disciplinary care and were followed up until discharge or death. Outcome variables of interest were ulcer healing, lower extremity amputation (LEA), duration of hospitalization and mortality. RESULTS A total of 336 patients (55.1% male) with mean age of 55.9 ± 12.5 years were enrolled into this study. Majority (96.1%) had type 2 diabetes. Only 25.9% of the subjects had prior foot care knowledge. Most of the subjects presented late to the hospital and median (IQR) duration of ulcer at presentation was 39 (28-54) d. Ulcers were already advanced (Wagner grades ≥ 3) in 79.2% of the subjects while 76.8% of the ulcers were infected at the time of admission. The commonest comorbidities were systemic hypertension, anemia and hyperglycemic emergencies. One hundred and nineteen subjects (35.4%) suffered LEA while 10.4% left against medical advice. The median (IQR) duration of hospitalization was 52.0 (29-66) d with case fatality rate of 20.5%. CONCLUSION The burden of DFU in Nigeria is very high. The major gaps include low level of foot care knowledge among diabetic patients, overdependence on self-medication and unorthodox medicine following development of foot ulceration, late hospital presentation, and high amputation and mortality rates. Extensive foot care education within the framework of a multi-disciplinary foot care team is highly desirable. | Ejiofor Ugwu Olufunmilayo Adeleye Ibrahim Gezawa Innocent Okpe Marcelina Enamino Ignatius Ezeani | 2019 | World Journal of Diabetes2019，10，3： | 5 |
| 3 | Anticancer potential of metabolic compounds from marine actinomycetes isolated from Lagos Lagoon sediment显示文摘Thirty-two actinomycetes strains were isolated from sediment samples from 12 different sites at Lagos Lagoon and identified using standard physiological and biochemical procedures as well as 16S rDNA gene sequence analysis. Secondary metabolites were extracted from the strains and their anticancer activity on the K562 (Human acute myelocytic leukemia), HeLa (cervical carcinoma), AGS (Human gastric), MCF- 7 (breast adenocarcinoma) and HL-60 (Human acute promyelocytic leukemia) cell lines was determined. The metabolic extracts exhibited cytotoxicity with IC50 values ranging from 0.030 mg/mL to 4.4 mg/mL. The Streptomyces bingchenggensis ULS14 extract was cytotoxic against all the cell lines tested. The bioactivity-guided extraction and purification of the metabolic extracts from this strain yielded two purified anticancer compounds: ULDF4 and ULDF5. The structures of the extracted compounds were determined using spectroscopic analyses, including electrospray ionization mass spectrophotometer and nuclear magnetic resonance (1 Dimensional and 2 Dimensional), and were shown to be structurally similar to staurosporine and kigamicin. The IC50 of ULDF4 and ULDF5 against the HeLa cell line was 0.034 mg/mL and 0.075 mg/mL, respectively. This study is the first to reveal the anticancer potential of actinomycetes from Lagos Lagoon, which could be exploited for therapeutic purposes. | Olabisi Flora Davies-Bolorunduro Isaac Adeyemi Adeleye Moshood Olushola Akinleye Peng George Wang | 2019 | Journal of Pharmaceutical Analysis2019，9，3： | 3 |
| 4 | Primary renal non- Hodgkins lymphoma presenting with acute renal failure显示文摘 | Olusanya AA Huff G Adeleye O | 2003 | J Natl Med Assoc2003，95，3： | 1 |
| 5 | Frequent occurrence of high gamma-glutamyl transferase and alanine amino transferase among Nigerian patients with type 2 diabetes显示文摘 | Balogun WO Adeleye JO Akinlade KS | 2008 | Afr J Med Med Sci2008，37，2： | 1 |
| 6 | Managed Pressure Drill- ing (MPD) Field Trials Demonstrate Technology Value 显示文摘 | Saponja J Adeleye A Hucik Bu | 2006 | IADC/SPE 987872006，，： | 1 |
| 7 | Tramadol improved the efficacy of ketamine-xylazine anaesthesia in young pigs显示文摘 | Ajadi A R Olusa T A Smith O F Ajibola E S Adeleye O E Adenubi O T Makinde F A | | 0，，： | 1 |
| 8 | Agile supply chain capabilities: determinants of competitive objectives显示文摘 | Yusuf Y Y Gunasekaran A Adeleye E O | 2004 | European Journal of Operational Research2004，159，2： | 1 |
| 9 | Cervical Klippel-Feil syn-drome predisposing an elderly African man to centralcord myelopathy following minor trauma 显示文摘 | Adeleye AO Akinyem RO | 2010 | AfrHealth Sci2010，10，3： | 1 |
| 10 | Implementing Toxicity Testing in the 21st Century (TF21C): making safety decisions using toxicity pathways, and progress in a prototype risk assessment 显示文摘 | ADELEYE Y ANDERSEN M CLEWELL R | 2015 | Toxicology2015，332，： | 1 |
| 11 | New triterpene isovanniloyl and antibacterial activity of constituents ftonl the roots of PauUinia pinnata Linn(Sapindaceae)显示文摘 | AA Lasisi BW Ayinde AO Adeleye | 2012 | Journal of Sau- di Chemical Society2012，，： | 1 |
| 12 | Thoracic aortic dissection in a patient with autosomal dominant polycystic kidney disease显示文摘 | Adeola T Adeleye 0 Potts 1L | 2001 | J Natl Med Assoc2001，93，78： | 1 |
| 13 | Post-operative day two versus day seven mobilization after burr-hole drainage of subacute and chronic subdural haematoma in Nigerians 显示文摘 | Adeolu AA Rabiu TB Adeleye AO | 2012 | Br J Neurosurg2012，26，5： | 1 |
| 14 | Implementing Toxicity Testing in the 21st Century(TT21C):Making safety decisions using toxicity pathways,and progress in a prototype risk assessment显示文摘 | Adeleye Y Andersen M Clewell R Davies M Dent M Edwards S | 2015 | Toxicology2015，332，： | 1 |
| 15 | Primary renal non-Hodgkin's lymphoma presenting with acute renal failure显示文摘 | Olusanya AA Huff G Adeleye O | 2003 | J Natl Med Assoc2003，95，3： | 1 |
| 16 | Aggregate cardiovascular riskis a stronger statistical correlate of clinically evident diabetic peripheral neuropathy than HbAlc alone 显示文摘 | Owolabi MO Ipadeola A Adeleye JO | 2010 | J Natl Med Assoc2010，102，8： | 1 |
| 17 | Prevention of myelomeningocele:Af rican perspectives 显示文摘 | Rabiu TB Adeleye AO | 2013 | Childs Nerv Syst2013，29，9： | 1 |
| 18 | Screening for peripheral neuropathy and peripheral arterial disease in persons with diabetes mellitus in a Nigerian University Teaching Hospital 显示文摘 | Ogbera AO Adeleye O Solagberu B | 2015 | BMC Res Notes2015，8，： | 1 |
| 19 | Agile Supply Chain Capabilities:Determinants of Competitive Objectives显示文摘 | Y Y Yusuf A Gunasokaran E O Adeleye | 2004 | European Journal of Operational Research2004，159，2： | 1 |
| 20 | The pattern of fracture of the facial skeleton in Kaduna,Nigeria显示文摘 | Adeleye E O | 1980 | Oral Surg Oral Med Oral Pathol1980，49，6： | 1 |
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