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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Low-grade gliomas:do changes in rCBV measurements at longitudinal perfusion-weighted MR imaging predict malignant transformation?显示文摘Radiology. 2008 Apr;247(1):170-8.PURPOSE: To prospectively perform longitudinal magnetic resonance (MR) perfusion imaging of conservatively treated low-gradegliomas to determine whether relative cerebral blood volume (rCBV) changes precede malignant transformation as defined | Danchaivijitr N Waldman AD Tozer DJ Benton CE Brasil Caseiras G Tofts PS Rees JH J?ger HR | 2008 | 中国神经肿瘤杂志2008，6，2： | 7 |
| 3 | Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial显示文摘 | JY Douillard D Cunningham AD Roth M Navarro RD James P Karasek P Jandik T Iveson J Carmichael M Alakl G Gruia L Awad P Rougier | 2000 | The Lancet2000，，9209： | 4 |
| 4 | Prevalence and correlates of aggressive behavior in psychiatric inpatient populations显示文摘Aggressive behavior in patients with psychiatric disorders is attracting increasing research interest.One reason for this is that psychiatric patients are generally considered more likely to be aggressive,which raises a related question of whether diagnoses of psychiatric disorders predict the prevalence of aggressive behavior.Predicting aggression in psychiatric wards is crucial,because aggressive behavior not only endangers the safety of both patients and staff,but it also extends the hospitalization times.Predictions of aggressive behavior also need careful attention to ensure effective treatment planning.This literature review explores the relationship between aggressive behavior and psychiatric disorders and syndromes(dementia,psychoactive substance use,acute psychotic disorder,schizophrenia,bipolar affective disorder,major depressive disorder,obsessivecompulsive disorder,personality disorders and intellectual disability).The prevalence of aggressive behavior and its underlying risk factors,such as sex,age,comorbid psychiatric disorders,socioeconomic status,and history of aggressive behavior are discussed as these are the components that mostly contribute to the increased risk of aggressive behavior.Measurement tools commonly used to predict and detect aggressive behavior and to differentiate between different forms of aggressive behavior in both research and clinical practice are also reviewed.Successful aggression prevention programs can be developed based on the current findings of the correlates of aggressive behavior in psychiatric patients. | Hunor Girasek Vanda Adél Nagy Szabolcs Fekete Gabor S Ungvari Gábor Gazdag | 2022 | World Journal of Psychiatry2022，12，1： | 4 |
| 5 | Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease显示文摘The search for biomarkers that characterize specific aspects of inflammatory bowel disease(IBD), has received substantial interest in the past years and is moving forward rapidly with the help of modern technologies. Nevertheless, there is a direct demand to identify adequate biomarkers for predicting and evaluating therapeutic response to different therapies. In this subset, pharmacogenetics deserves more attention as part of the endeavor to provide personalized medicine. The ultimate goal in this area is the adjustment of medication for a patient's specific genetic background and thereby to improve drug efficacy and safety rates. The aim of the following review is to utilize the latest knowledge on immunopathogenesis of IBD and update the findings on the field of Immunology and Genetics, to evaluate the response to the different therapies. In the present article, more than 400 publications were reviewed but finally 287 included based on design, reproducibility(or expectancy to be reproducible and translationable into humans) or already measured in humans. A few testshave shown clinical applicability. Other, i.e., genetic associations for the different therapies in IBD have not yet shown consistent or robust results. In the close future it is anticipated that this, cellular and genetic material, as well as the determination of biomarkers will be implemented in an integrated molecular diagnostic and prognostic approach to manage IBD patients. | Emilio G Quetglas Zlatan Mujagic Simone Wigge Daniel Keszthelyi Sebastian Wachten Ad Masclee Walter Reinisch | 2015 | World Journal of Gastroenterology2015，21，44： | 3 |
| 6 | Eosinophilic esophagitis: Current concepts in diagnosis and treatment显示文摘Eosinophilic esophagitis is an immune-allergic pathology of multifactorial etiology(genetic and environmental)that affects both pediatric and adult patients.Its symptoms,which include heartburn,regurgitation,and esophageal stenosis(with dysphagia being more frequent in eosinophilic esophagitis in young adults and children),are similar to those of gastroesophageal reflux disease,causing delays in diagnosis and treatment.Although endoscopic findings such as furrows,esophageal mucosa trachealization,and whitish exudates may suggest its presence,this diagnosis should be confirmed histologically based on the presence of more than 15 eosinophils per high-power field and the exclusion of other causes of eosinophilia(parasitic infections,hypereosinophilic syndrome,inflammatory bowel disease,among others)for which treatment could be initiated.Currently,the 3“D”s(“Drugs,Diet,and Dilation”)are considered the fundamental components of treatment.The first 2 components,which involve the use of proton pump inhibitors,corticosteroids,immunosuppressants and empirical diets or guided food elimination based on allergy tests,are more useful in the initial phases,whereas endoscopic dilation is reserved for esophageal strictures.Herein,the most important aspects of eosinophilic esophagitis pathophysiology will be reviewed,in addition to evidence for the various treatments. | Andrés Gómez-Aldana Mario Jaramillo-Santos Andrés Delgado Carlos Jaramillo Adán Lúquez-Mindiola | 2019 | World Journal of Gastroenterology2019，25，32： | 2 |
| 7 | HER2 and response to paelitaxel in node-positive breast cancer显示文摘 | Hayes DF Thor AD Dressier l G | 2007 | N Engl J Med2007，357，15： | 1 |
| 8 | Transcranial ultrasound in clinical sonothrombolysis(TUCSON)trial显示文摘 | Molina CA Barreto AD Tsivgoulis G | 2009 | Ann Neurol2009，66，1： | 1 |
| 9 | Extraskeletal myxoid chon-drosarcoma:a retrospective review from2referral centers emphasi-zing long-term outcomes with surgery and chemotherapy显示文摘 | Drilon AD Popat S Bhuchar G | 2008 | Cancer2008，113，12： | 1 |
| 10 | Microvascular dysfunction in acute myocardial infarction:Focus on the roles of platelet and inflammatory mediators in the no-reflow phenomenon显示文摘 | Michaels AD Michael G Barron HV | 2000 | Am J Cardiol2000，85，： | 1 |
| 11 | Making antibodies by phage display technology 显示文摘 | Winter G Griffiths AD Hawkins RE | 1994 | Annu Rev Immunol1994，12，： | 1 |
| 12 | Reduction in gram- positive pneumonia and antibiotic consumption following the use of a SDD protocol including nasal and oral mupirocin显示文摘 | Nardi G Di - Silvestre AD De - Monte A | 2001 | Eur J Emerg Med2001，8，3： | 1 |
| 13 | Perioperative lateral tro- chanteric wall fractures:sliding hip screw versus percutaneous com- pression plate for intertrochanteric hip fractures 显示文摘 | Langford J Pillai G Ugliailoro AD | 2011 | Orthop Trauma2011，25，4： | 1 |
| 14 | Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle,evidence for capillary recruitment显示文摘 | BARON AD TARSHOBY M HOOK G | 2000 | Diabetes2000，49，5： | 1 |
| 15 | Transforming grow factor beta 1 induces neointima formation through plasminogen activator inhibitorldependent pathways显示文摘 | Otsuka G Agah R Frutkin AD | 2006 | Artefioscler Thromb Vasc Biol2006，26，4： | 1 |
| 16 | Postconditioning is an effective strategy to reduce renal ischemia /reperfusion injury 显示文摘 | Serviddio G Romano AD Gesualdo L | 2008 | Nephrol Dial Transplant2008，23，5： | 1 |
| 17 | Enteropathogenic and enterohaemorrhagic Escherichia coli:more subversive elements显示文摘 | Frankel G Phillips AD Rosenshine I | 1998 | Mol Microbiol1998，30，： | 1 |
| 18 | Wavelet analysis of blood pressure waves in vasovagal syncope显示文摘 | Marrone A Polosa AD Scioscia G | 1999 | Physics1999，，271： | 1 |
| 19 | Lymphomatoid granulo- matosis: abnormalities of the brain at MR imaging 显示文摘 | Patsalides AD Atac G Hedge U | 2005 | Radiolo- gy2005，237，： | 1 |
| 20 | The role of iron nutrition in photosynthesis and nitrogen assimilation in scenedesmus quadricauda ( Chlorophyceae ) 显示文摘 | RUETER J G ADES D R | 1987 | Journal of Phycology1987，23，3： | 1 |
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