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| 1 | SOX9 in biliary atresia: New insight for fibrosis progression显示文摘Background:Liver fibrosis is a hallmark determinant of morbidity in biliary atresia(BA)even in successfully operated cases.Responsible factors for this rapid progression of fibrosis are not completely defined.Aberrant expression of the transcription factor SOX9 and hepatic progenitor cells(HPCs)proliferation have roles in fibrogenesis in cholestatic disorders.However,they were not investigated sufficiently in BA.We aimed to delineate the relation of SOX9 and HPCs to fibrosis and its progression in BA.Methods:Forty-eight patients with BA who underwent an initial diagnostic liver biopsy(LB)and consequent intraoperative LB were recruited and compared to 28 cases with non-BA cholestasis that had an LB in their diagnostic workup.Liver fibrosis,tissue SOX9 and HPC expressions were studied in both BA and non-BA-cholestasis cases.Liver fibrosis,SOX9,and HPCs’dynamic changes in BA cases were assessed.Relation of fibrosis and its progression to SOX9 and HPCs in BA was assessed.Results:SOX9 and HPCs in ductular reaction(DR)form were expressed in 100%of BA and their grades increased significantly in the second biopsy.The rapidly progressive fibrosis in BA,represented by fibrosis grade of the intraoperative LB,correlated significantly to SOX9-DR and HPC-DR at the diagnostic(r=0.420,P=0.003 and r=0.405,P=0.004,respectively)and the intraoperative(r=0.460,P=0.001 and r=0.467,P=0.001,respectively)biopsy.On the other hand,fibrosis,SOX9-DR,and HPC-DR were significantly lower in non-BA cases at a comparable age(P<0.001,P=0.006,and P=0.014,respectively).Conclusions:Fibrosis in BA is rapidly progressive within a short time and is significantly correlated to SOX9 and HPCs.Assessment of targeting SOX9 and HPCs on fibrosis progression is warranted. | Hanaa Ahmed El-Araby Magdy Anwar Saber Noha Mohamed Radwan Doha Maher Taie Nermin Mohamed Adawy Ahmad Mohamed Sira | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，2： | 3 |
| 2 | Effects of different probiotic strains of Lactobacillus and Bifidobacterium on bacterial translocation and liver injury in an acute liver injury model显示文摘 | Adawi D Ahrne S | 2001 | Int J Food Microbiol2001，70，3： | 1 |
| 3 | Monitoring of cultivar identity in tissue culture-derived date palms using RAPD and AFLP analysis显示文摘 | Saker M M Adawy S S Mohamed A A | 2006 | Biol Plant2006，50，2： | 1 |
| 4 | Nutritional,composition and antinutritional factors of chickpeas (Cicer arietinum L)undergoing different cooking methods and germination显示文摘 | Tark A Adawy E L | 2002 | Plant Foods for Human Nutrition2002，57，： | 1 |
| 5 | Endotoxin - and D - galac-tosamine - induced liver injury improved by the administration ofLactobacillus,Bifidobacterium and blueberry显示文摘 | Osman N Adawi D Ahm6 S | 2007 | Dig Liver Dis2007，39，9： | 1 |
| 6 | Regulation of IgE and Cytokine Production by cAMP: Implication for Extrinsic Asthma 显示文摘 | Fedyk E R Adawi A Looney R J | 1996 | Clinical Immunology and Immunopathology1996，81，2： | 1 |
| 7 | Detection of genetic diversity in Campylobacterjejuni isolated from a commercial tur- key flock using flaA typing, MLST analysis and microarray as- say显示文摘 | E1 Adawy H Hotzel H Tomaso H | 2013 | PloSOne2013，8，51： | 1 |
| 8 | A novel fully differential current conveyor and applications for analog VLSI显示文摘 | Ahmed A Adawy E I Ahmed M S | 2000 | IEEE Transactions on Circuits and Systems I2000，47，4： | 1 |
| 9 | Observation of in-plane polarized intersublevel absorption in strongly coupled InGaAs/GaAs self assembled quantum dots显示文摘 | ADAWI A M ZIBIK E A WILSON L R | 2003 | Phys Stat Sol (b)2003，238，： | 1 |
| 10 | Administration of Lactobacillus plantarum 299v Reduces Sideeffects of External Radiation on Colon Anastomotic Healing in an Experimental Model显示文摘 | LIU Q NOBAEK S ADAWI D | 2001 | Colorectal Disease2001，3，： | 1 |
| 11 | Characteristics and composition of different seed oils and flours 显示文摘 | Adawy T Taha K M | 2001 | Food Chemistry2001，74，1： | 1 |
| 12 | Effects pf dlifferent probiotic strains of laetobaeillus and bifidobacterum on bactenal translocation and liver injury in acute liennjury mode显示文摘 | Adawi D Ahme S Milin G | 2001 | Lnt J Food Microbiol2001，70，3： | 1 |
| 13 | Diplodia theobromae associated with sudden decline of mango in the Sultanate of Oman显示文摘 | A1 Adawi A O Deadman M L A1 Rawahi A K | 2003 | Plant pathology2003，52，： | 1 |
| 14 | Inhibition of matrix metalloproteinases enhances breaking strength of colonic anastomoses in an experimental model显示文摘 | Syk I (A)gren M S Adawi D | | 0，，2： | 1 |
| 15 | Antinuclear antibodies measured by enzyme immunoassay in patients with systemic lupus erythematosus: relation to disease activity 显示文摘 | Paz E Adawi M Lavi I | 2007 | Rheumatol Int2007，27，10： | 1 |
| 16 | Effects of different probiotic strains of Lactobacillus and Bifidobacterium on bacterial translocation and liver injury in an acute liver injury model显示文摘 | ADAWI D AHRN? S MOLIN G | 2001 | Int J Food Microbiol2001，70，3： | 1 |
| 17 | Thyroid dysfunction in patients with systemic lupus erythematosus (SLE):relation to disease activity显示文摘 | Mader R Mishail S Adawi M | 2007 | Clin Rheumatol2007，26，： | 1 |
| 18 | Administration of Lactoba- ciltus plantarum 299v reduces side-effects of external radiation on colon anastomofic healing in an experimental model显示文摘 | Liu Q Nobaek S Adawi D et aI | 2001 | Colorectal Dis2001，3，4： | 1 |
| 19 | The pe:riodontal ligament injection: a solitary method for inducing local anesthesia 显示文摘 | Mansour MS Adawy AM | 1985 | Egypt Dent J1985，31，2： | 1 |
| 20 | Modulation of the effect of dextran sulfate sodium-induced acute colitis by the administration of different probiotic strains of Lactobacillus and Bifidobacterium显示文摘 | Osman N Adawi D Ahrne S | 2004 | Dig Dis Sci2004，49，2： | 1 |
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