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| 1 | Portal vein thrombosis and arterioportal shunts:Effects on tumor response after chemoembolization of hepatocellular carcinoma显示文摘AIM: To evaluate the effect of portal vein thrombosis and arterioportal shunts on local tumor response in advanced cases of unresectable hepatocellular carcinoma treated by transarterial chemoembolization. METHODS: A retrospective study included 39 patients (mean age: 66.4 years, range: 45-79 years, SD: 7) with unresectable hepatocellular carcinoma (HCC) who were treated with repetitive transarterial chemoembolization (TACE) in the period between March 2006 and October 2009. The effect of portal vein thrombosis (PVT) (in 19 out of 39 patients), the presence of arterioportal shunt (APS) (in 7 out of 39), the underlying liver pathology,Child-Pugh score, initial tumor volume, number of tumors and tumor margin definition on imaging were correlated with the local tumor response after TACE. The initial and end therapy local tumor responses were evaluated according to the response evaluation criteria in solid tumors (RECIST) and magnetic resonance imaging volumetric measurements. RESULTS: The treatment protocols were well tolerated by all patients with no major complications. Local tumor response for all patients according to RECIST criteria were partial response in one patient (2.6%), stable disease in 34 patients (87.1%), and progressive disease in 4 patients (10.2%). The MR volumetric measurements showed that the PVT, APS, underlying liver pathology and tumor margin definition were statistically significant prognostic factors for the local tumor response (P = 0.018, P = 0.008, P = 0.034 and P = 0.001, respectively). The overall 6-, 12- and 18-mo survival rates from the initial TACE were 79.5%, 37.5% and 21%, respectively. CONCLUSION: TACE may be exploited safely for palliative tumor control in patients with advanced unresectable HCC; however, tumor response is significantly affected by the presence or absence of PVT and APS. | Thomas J Vogl Nour-Eldin Nour-Eldin Sally Emad-Eldin Nagy NN Naguib Joerg Trojan Hans Ackermann Omar Abdelaziz | 2011 | World Journal of Gastroenterology2011，17，10： | 20 |
| 2 | Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing显示文摘In recent years,femtosecond(fs)-lasers have evolved into a versatile tool for high precision micromachining of transparent materials because nonlinear absorption in the focus can result in refractive index modifications or material disruptions.However,when high pulse energies or low numerical apertures are required,nonlinear side effects such as self-focusing,filamentation or white light generation can decrease the modification quality.In this paper,we apply simultaneous spatial and temporal focusing(SSTF)to overcome these limitations.The main advantage of SSTF is that the ultrashort pulse is only formed at the focal plane,thereby confining the intensity distribution strongly to the focal volume and suppressing detrimental nonlinear side effects.Thus,we investigate the optical breakdown within a water cell by pump-probe shadowgraphy,comparing conventional focusing and SSTF under equivalent focusing conditions.The plasma formation is well confined for low pulse energies,2 mJ,but higher pulse energies lead to the filamentation and break-up of the disruptions for conventional focusing,thereby decreasing the modification quality.In contrast,plasma induced by SSTF stays well confined to the focal plane,even for high pulse energies up to 8 mJ,preventing extended filaments,side branches or break-up of the disruptions.Furthermore,while conventional focusing leads to broadband supercontinuum generation,only marginal spectral broadening is observed using SSTF.These experimental findings are in excellent agreement with numerical simulations of the nonlinear pulse propagation and interaction processes.Therefore,SSTF appears to be a powerful tool to control the processing of transparent materials,e.g.,for precise ophthalmic fs-surgery. | Robert Kammel Roland Ackermann Jens Thomas Jorg Gotte Stefan Skupin Andreas Tunnermann Stefan Nolte | 2014 | Light(Science & Applications)2014，3，1： | 11 |
| 3 | Correlation of lumbar lateral recess stenosis in magnetic resonance imaging and clinical symptoms显示文摘AIM To assess the correlation of lateral recess stenosis(LRS) of lumbar segments L4/5 and L5/S1 and the Oswestry Disability Index(ODI).METHODS Nine hundred and twenty-seven patients with history of low back pain were included in this uncontrolled study.On magnetic resonance images(MRI) the lateral recesses(LR) at lumbar levels L4/5 and L5/S1 were evaluated and each nerve root was classified into a 4-point grading scale(Grade 0-3) as normal,not deviated,deviated or compressed.Patient symptoms and disability were assessed using ODI.The Spearman's rank correlation coefficient was used for statistical analysis(P < 0.05).RESULTS Approximately half of the LR revealed stenosis(grade 1-3;52% at level L4/5 and 42% at level L5/S1) with 2.2% and 1.9% respectively reveal a nerve root compression.The ODI score ranged from 0%-91.11% with an arithmetic mean of 34.06% ± 16.89%.We observed a very weak statistically significant positive correlation between ODI and LRS at lumbar levels L4/5 and L5/S1,each bilaterally(L4/5 left:rho < 0.105,P < 0.01;L4/5 right:rho < 0.111,P < 0.01;L5/S1 left:rho 0.128,P < 0.01;L5/S1 right:rho < 0.157,P < 0.001).CONCLUSION Although MRI is the standard imaging tool for diagnosing lumbar spinal stenosis,this study showed only a weak correlation of LRS on MRI and clinical findings.This can be attributed to a number of reasons outlined in this study,underlining that imaging findings alone are not sufficient to establish a reliable diagnosis for patients with LRS. | Annina SplettstoBer M Fawad Khan Bernd Zimmermann Thomas J Vogl Hanns Ackermann Marcus Middendorp Adel Maataoui | 2017 | World Journal of Radiology2017，9，5： | 4 |
| 4 | 过渡金属催化的区域选择性芳烃C—H键氧化生成C—O键(英文)显示文摘近年来过渡金属催化的芳烃直接C—H氧化反应取得了重要进展,该策略被用于多种酚类化合物的制备.反应体系使用的过渡金属催化剂包括钯、铜、钌、铱等;氧化剂包括高价碘化合物、过硫酸盐、氧气等.此前已有多篇综述就特定的过渡金属或氧化剂参与的C—H氧化反应进行了详尽的讨论.本综述着重探讨过渡金属催化的邻、间、对位选择性的芳烃C—H氧化反应,并试图阐释上述区域选择性的产生机制,其中包括导向基团的螯合辅助作用、配体控制、底物自身因素等.在讨论部分提出了过渡金属催化的芳烃C—H氧化反应中存在的问题以及影响该策略发展应用的可能限制因素. | 杨帆致 张晗 刘旭日 王博 Lutz Ackermann | 2019 | 有机化学2019，39，1： | 4 |
| 5 | Treatment of small coronary arteries with a paclitaxel-coated balloon catheter显示文摘 | Martin Unverdorben Franz X. Kleber Hubertus Heuer Hans-Reiner Figulla Christian Vallbracht Matthias Leschke Bodo Cremers Stefan Hardt Michael Buerke Hanns Ackermann Michael Boxberger Ralf Degenhardt Bruno Scheller | 2010 | Clinical Research in Cardiology2010，，3： | 2 |
| 6 | 肾细胞癌肝转移的多次经动脉化疗栓塞术后局部控制及生存疗效的评价显示文摘本研究的目的是评价经动脉化疗栓塞(TACE)对肾细胞癌(RCC)肝脏转移灶的局部治疗及生存的效果。采用前瞻洼的研究方法,评价1999--2005年22例病人经TACE治疗的效果。45%的病人仅用丝裂霉素作为化疔药物,55%的病人同时使用丝裂霉索与吉西他滨(gemcitabine)。所有病例的栓塞材料均为碘化油和可降解淀粉微球。采用MRI评价局部治疗反应,并参照实体肿瘤治疗效果评价标准(RECIST)做出判断。用KM法计算平均和中位生存时间、 | M. Nabil T. Gruber D. Yakoub H. Ackermann S. Zangos T.J. Vogl. 邢艳(译) 刘文亚(校) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 2 |
| 7 | Completion of the Porcine Epidemic Diarrhoea Coronavirus (PEDV) Genome Sequence显示文摘 | Rolf Kocherhans Anne Bridgen Mathias Ackermann Kurt Tobler | 2001 | Virus Genes2001，，2： | 2 |
| 8 | Cobaltaelectro-Catalyzed C—H Acyloxylation显示文摘Cobaltaelectrocatalysis set the stage for sustainable C—H acyloxylations in biomass-derived γ-valerolactone as a renewable solvent. The sustainable electrocatalysis regime featured ample scope, along with high levels of chemo- and position-selectivity. | Cong Tian Uttam Dhawa Julia Struwe Lutz Ackermann | 2019 | Chinese Journal of Chemistry2019，37，6： | 2 |
| 9 | Fibroblast Growth Factors and Their Receptors in Urological Cancers: Basic Research and Clinical Implications显示文摘 | M.V Cronauer W.A Schulz H.-H Seifert R Ackermann M Burchardt | 2003 | European Urology2003，，3： | 2 |
| 10 | The adaptation of the permanent fish cell lines PLHC-1 and RTG-2 to FCS- free media results in similar growth rates compared to FCS-containing Conditions 显示文摘 | Ackermann G E Fent K | 1998 | Mar Environ Res1998，46，4： | 1 |
| 11 | Deletion of 13q14 remains an independent adverseprognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization显示文摘 | ZOJER N KONIGSBERG R ACKERMANN J | 2000 | Blood2000，95，： | 1 |
| 12 | The role of mass-spectrometry in biomarker discovery and measurement显示文摘 | Ackermann BL Hale JE Duffin KL | 2006 | Curr Drug Metab2006，7，5： | 1 |
| 13 | The influence of sulindac on patients with primary biliary cirrhosis that responds incompletely to ursodeoxycholic acid:a pilot study显示文摘 | Leuschner M Holtmeier J Ackermann H | 2002 | Eur J Gastroenterol Hepatol2002，14，12： | 1 |
| 14 | Electric events synchronized with laser filaments in thunderclouds显示文摘 | KASPARIAN J ACKERMANN R ANDR Y B | | 0，，08： | 1 |
| 15 | A tissue engineered cell-occlusive device for hard tissue regeneration--a preliminary report显示文摘 | Hutmacher DW Kirsch A Ackermann KL | | 0，，： | 1 |
| 16 | Tailed bacteriophages: the order caudovirales 显示文摘 | Ackermann HW | 1998 | Adv Virus Res1998，51，4： | 1 |
| 17 | Modeling the formation of secondary organic aerosol within a comprehensive air quality model system 显示文摘 | Schell B Ackermann I J Hass H | 2001 | Journal of Geophysical Research Atmospheres2001，106，28： | 1 |
| 18 | Quorum quench- ing and antimicrobial activity of goldenseal (Hydrastis canaden- s/s) against methicillin-resistant Staphylococcus aureus (MRSA) 显示文摘 | Cech N B Junio H A Ackermann L W | 2012 | Planta Med2012，78，14： | 1 |
| 19 | Integrating variable renewables in europe: current status and recent extreme events显示文摘 | ACKERMANN T CARLINI E M ERNST B | 2015 | IEEE Power and Energy Magazine2015，13，6： | 1 |
| 20 | Color Doppler sonography of the prostate显示文摘 | Miller SM Ackermann RI | 1996 | Urol Int1996，57，3： | 1 |
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