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| 1 | 限制性与自由输血策略对心血管疾病患者非心脏手术效果的影响:系统回顾与Meta分析显示文摘目的比较采取限制性与自由输血策略的心血管疾病患者的非心脏手术结局。数据来源搜集涉及医院红细胞输注阈值的随机控制试验。检索CENTRAL、Medline、EMBase、CINAHL、PubMed、LILACS、NHSBT输血证据库、Clinical Trials.gov、WHO国际临床试验注册平台、国际标准随机对照临床试验编号登记、欧盟临床试验登记。检索时间为2015-11-02之前。试验选择选取发表与未发表的比较限制性与自由输血阈值的随机控制试验,试验均纳入心血管疾病患者。结果检索到41项试验,其中7项试验纳入心血管疾病患者。另选取4项纳入心血管疾病患者的试验。最终共搜集11项纳入心血管疾病患者(n=3 033)的试验进行Meta分析(限制性输血1 514例,自由输血1 519例)。输血阈值与30 d死亡率之间联系的汇集风险比例为1.15〔95%CI(0.88,1.50),P=0.50〕,异质性较小(I^2=14%)。限制性输血患者的急性冠脉综合征风险与自由输血患者相比更高〔9项试验;风险比例1.78,95%CI(1.18,2.70),P=0.01,I^2=0%〕。结论对急性冠脉综合征或慢性心血管疾病患者采取80 g/L以下的限制性输血阈值可能并不安全,对病死率与其他结局的影响并不确定。这些数据可暂时支持对急性或慢性心血管疾病患者使用更加自由的输血阈值(>80 g/L),但有待更具有说服力的高质量的心血管疾病患者随机试验进行验证。 | Docherty AB O' Donnell R Brunskill S 本刊编辑部 | 2016 | 中国全科医学2016，19，15： | 12 |
| 2 | 心血管健康研究中血压轨迹与死亡率、心血管病事件和心力衰竭的关系显示文摘老年人的一般血压轨迹尚未明确,其与临床结局的关系也尚不确定。方法:本研究采用层次聚类分析法来确定心血管健康研究中4067参与者从0~7年重复测量血压值的血压轨迹。然后采用Cox比例风险回归模型评估每种血压轨迹聚类与全因死亡率、 | Smitson CC Scherzer R Shlipak MG Psaty BM Newman AB Sarnak MJ Odden MC Peralta CA 陈云 叶鹏 | 2018 | 中华高血压杂志2018，26，2： | 3 |
| 3 | SYFPEITHI: database for MHC ligands and peptide motifs显示文摘 | Hans-Georg R Jutta B Oskar AB | 1999 | Immunogenetics1999，50，： | 2 |
| 4 | Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism显示文摘AIM:To investigate if and how the proinflammatory cytokine interferon γ(IFNγ) affects ghrelin expression in mice.METHODS:The plasma concentration of ghrelin,andgastric ghrelin and somatostatin expression,were examined in wild-type mice and mice infected with Helicobacter pylori(H.pylori).Furthermore,ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth.To study the effect of IFNγ alone,mice were given a subcutaneous infusion of IFNγ for 7 d.Finally,the influence of IFNγ and somatostatin on the ghrelin promoter was characterized.RESULTS:H.pylori infection was associated with a 50% reduction in ghrelin expression and plasma concentration.Suppression of ghrelin expression was inversely correlated with gastric inflammation in achlorhdyric mouse models.Subcutaneous infusion of IFNγ suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations.Finally,we showed that the ghrelin promoter operates under the control of somatostatin but not under that of IFNγ.CONCLUSION:Gastric infection and inflammation is associated with increased IFNγ expression and reduced ghrelin expression.IFNγ does not directly control ghrelin expression but inhibits it indirectly via somatostatin. | Jesper AB Strickertsson Kristina BV DΦssing Anna JM Aabakke Hans-Olof Nilsson Thomas VO Hansen Ulrich Knigge Andreas Kjr Torkel Wadstrm Lennart Friis-Hansen | 2011 | World Journal of Gastroenterology2011，17，26： | 2 |
| 5 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 6 | Dexaracthasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells显示文摘 | Matssic R Dietz AB Vuk-Pavlovic S | 1999 | J Leukoc Biol1999，66，6： | 1 |
| 7 | Molecular phenotypingof human ovarian cancer stem cells unravels the mecha-nisms for repair and chemoresistance显示文摘 | Alvero AB Chen R Fu HH | 2009 | Cell Cycle2009，8，1： | 1 |
| 8 | Improved green fluorescence显示文摘 | Heim R Cubitt AB Tsien RY | 1995 | Nature1995，373，： | 1 |
| 9 | Progression and regression of sleep-disordered breathing with changes in weights the sleep heart health study 显示文摘 | Newman AB Foster G Givelber R | 2005 | Arch Intern Med2005，165，20： | 1 |
| 10 | Cell penetrating peptides: overview and applications to the delivery of oli- onucleotides显示文摘 | Said hassane F Saleh AF Abes R | 2010 | Cell Mol Life Sci2010，67，5： | 1 |
| 11 | Use of HRP-2-based rapid diag- nostic test for Plasmodiumfolciparum malaria: assessing accuracy and cost effectiveness in the villages of Dielmo and Ndiop, Sene- gal显示文摘 | Ly AB Tall A Perry R | 2010 | Malar J2010，9，： | 1 |
| 12 | Genetically elevated non- fasting triglycerides and calculated remnant chalesteral as causal risk factors for myocardial infarction显示文摘 | JORGENSEN AB FRIKKE-SCHMIDT R WEST AS | 2013 | Eur Heart J2013，34，24： | 1 |
| 13 | Patterns of energy substrates during ischemia measured in the brain by microdialysis显示文摘 | Hlatky R Valadka AB Goodman JC | 2004 | J Neurotrauma2004，21，7： | 1 |
| 14 | Brain tissue oxygen tension response to induced hyperoxia reduced in hypoperfused brain显示文摘 | Hlatky R Valadka AB Gopinath SP | 2008 | J Neurosurg2008，108，： | 1 |
| 15 | Epigenetics of lung cancer 显示文摘 | Bowman R V Yang IA Semmler AB | 2006 | Respirology2006，11，： | 1 |
| 16 | Retrospective evaluation of the clinical and ra-diographic risk factors associated with severe pulmonary hemorrhage in first-line advanced,unresectable non-small cell lung cancer treated with Carboplatin and Paclitaxel plus bevacizumab显示文摘 | Sandler AB Schiller JH Gray R Dimery I Brahmer J Samant M Wang LI Johnson DH | 2009 | J Clin Onco2009，27，9： | 1 |
| 17 | Islet-1 cells are cardiac pro- genitors present during the entire lifespan : from the embryonic stage to adulthood 显示文摘 | Genead R Danielsson C Andersson AB | 2010 | Stem Cells Dev2010，19，10： | 1 |
| 18 | Managing rosacea:a review of the use of metronidazole alone and in combination with oral antibiotics显示文摘 | Conde JF Yelveton CB Balkrishnan R Fleischer AB Jr Feldman SR | 2007 | 6:495-4982007，6，： | 1 |
| 19 | Expression of seven herpes simplexvirus type 1 glycoproteins (gB, gC, gD, gE, gG, gH, and gl): comparative protection against lethal challenge in mice显示文摘 | Ghiasi H Kaiwar R Nesburn AB | 1994 | J Virol1994，68，4： | 1 |
| 20 | Morbidity and Mortality of Hartmann's Procedure for Sigmoid Volvulus at the university Hospital of Cocody,Abidjan显示文摘 | Kassi AB Lebeau R Yenon KS | | 0，，03： | 1 |
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