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| 1 | Influence of bioactive sulphated polysaccharide-protein complexes on hepatocarcinogenesis, angiogenesis and immunomodulatory activities显示文摘Objective:To explore the in vivo anticancer,anti-angiogenesis and immunomodulatory efficacies of the bioactive polysaccharide isolated from cold aqueous extract of Jania rubens(JCEM) and Pterocladia capillacea(PCEM) as well as hot aqueous extract of Enteromorpha intestinalis(EHEM) against hepatocellular carcinoma rat model(HCC) and to study their chemical composition.Methods:The sugars and amino acids composition of the bioactive polysaccharides of JCEM,PCEM and EHEM were determined using gas liquid chromatography and amino acid analyzer,respectively.These polysaccharide extracts(20 mg/kg b.wt.for 5 weeks) were assessed on hepatocarcinogenesis in rats and α-fetoprotein(AFP),carcinoembryonic antigen(CEA),glypican-3(GPC-3),hepatocyte growth factor(HGF) and vascular endothelial growth factor(VEGF) and Ig G levels were evaluated.Results:The GLC analysis of JCEM,PCEM and EHEM polysaccharide revealed the presence of 10,9 and10 sugars,in addition the amino acid analyser enable identification of 16,15 and 15 amino acids,respectively.These polysaccharide extracts of JCEM,PCEM and EHEM produced significant decrease in serum AFP,CEA,GPC-3,HGF and VEGF compared with untreated HCC group.JCEM,PCEM and EHEM had an immunostimulatory responses by increasing the IgG levels as compared by naive value(1.23,1.53 and 1.17 folds),respectively.The bioactive polysaccharides in HCC induced rats improved the humoral immune response.The photomicrographs of liver tissue sections of the groups of HCC treated with polysaccharide extracts of Jania rubens and Enteromorpha intestinalis showed intact histological structure.Moreover,fractions HE1,HE4,HE7 obtained from polysaccharide of EHEM showed moderate cytotoxic activity against Hep G2 in vitro with IC_(50) 73.1,42.6,76.2 μg/mL.However,fractions of PCEM and JCEM show no or weak cytotoxicity against Hep G2 in vitro where the cytotoxic activity of their crude polysaccharide extract proved synergetic effect.Conclusions:The pronounced antitumor activity of sulphated polysaccharide-protein complexes of JCEM and EHEM is due to direct cytotoxic activity,anti-hepatocarcinogensis,and anti-angiogenesis.In addition,JCEM,PCEM and EHEM had an immunostimulatory response and improved the humoral immune response in HCC induced rats. | Azza A.Matloub Hadeer A.Aglan Sahar Salah Mohamed El Souda Mona Elsayed Aboutabl Amany Sayed Maghraby Hanaa H.Ahmed | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，12： | 7 |
| 2 | Flavonoids, anti-inflammatory activity and cytotoxicity of Macfadyena unguiscati 显示文摘 | Aboutabl E A Hashem F A Sleem A A | 2008 | African Journal of Traditional Complementary and Alternative Medicines2008，5，1： | 1 |
| 3 | Water soluble polysaceharides extracted from Pterocladia capillacea and I)ictyopterismembranacea and their biological activities显示文摘 | A H AbouZeid E A Aboutabl A A Sleem | 2014 | Carbohydrate Polymers2014，113，： | 1 |
| 4 | Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450expression and arachidonic acid metabolism in rats显示文摘 | Zordoky BN Anwar-Mohamed A Aboutabl ME | 2010 | Toxicol Appl Pharmacol2010，242，1： | 1 |
| 5 | A comparative study of the essential oils from three Melaleuca species growing in Egypt显示文摘 | Aboutabl E A EI Tohamy S F De Footer H L | 1991 | Flavour and Fragrance Journal1991，6，2： | 1 |
| 6 | Water soluble polysaccharides extracted from Pterocladiacapillacea and Dictyopterismembranacea and their biological activities显示文摘 | A H AbouZeid E A Aboutabl A A Sleem | 2014 | Carbohydrate Polymers2014，113，： | 1 |
| 7 | Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats显示文摘 | Beshay N.M. Zordoky Anwar Anwar-Mohamed Mona E. Aboutabl Ayman O.S. El-Kadi | 2009 | Toxicology and Applied Pharmacology2009，，1： | 1 |
| 8 | Water soluble polysaccharides extracted from Pterocladia capiUacea and Dictyopteris membranacea and their biological activities 显示文摘 | Zeid A H A Aboutabl E A Sleem A A | 2014 | Carbohydr Polym2014，113，： | 1 |
| 9 | Antioxidant activity of methanolic extract of Bombax ceiba显示文摘 | Vieira T O Said A Aboutabl E | 2009 | Redox Report2009，14，1： | 1 |
| 10 | Water soluble polysaccharides extracted from Pterocladia capill acea and Dictyopteris membranacea and their biological activities显示文摘 | Abou Zeid AH Aboutabl EA Sleem AA | 2014 | Carbohydrate Polymers2014，，113： | 1 |
| 11 | 3-methylcholanthrene and benzo(a) pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats 显示文摘 | Aboutabl ME Zordoky BN E1-Kadi AO | 2009 | Br J Pharmacol2009，158，7： | 1 |
| 12 | Iridoids from Phlomis aurea decne growing in Egypt显示文摘 | Aboutabl E A Meselhy M R Afifi M S | 2002 | Pharmazie2002，57，9： | 1 |
| 13 | Modulation of cytochrome 17450 gene expression and arachidonic acid metabolism during soproterenol-induced cardiac hypertrophy in rats 显示文摘 | Zordoky BN Aboutabl ME EL-Kadi AO | 2008 | Drag Metab Dispos2008，36，11： | 1 |
| 14 | A comparative study of the essential oils from three Melaleuca species growing in Egypt显示文摘 | ABOUTABL E A EL TOHAMY S F DE FOOTER H L | 1991 | Flavour and Fragrance Journal1991，6，2： | 1 |
| 15 | Water soluble polysaccharides extracted from Pterocladia capillacea and Dictyopteris membranacea and their biological activities显示文摘 | Abou Zeid A H Aboutabl E A Sleem A A | 2014 | Carbohydrate Polymers2014，113，： | 1 |
| 16 | PMR assay of vincamine and formulations显示文摘 | Elsayed Aboutabl Aida E1-Azzouny Manal Afifi | 1998 | Pharmaceutica Acta Helvetiae1998，73，： | 1 |
| 17 | Modulation of cytochrome P450 gene expression and arachidonic acid metabolism during isoproterenol-induced cardiac hypertrophy in rats 显示文摘 | Zordoky BN Aboutabl ME El-kadi AO | 2008 | Drug Metab Dispos2008，36，11： | 1 |
| 18 | Acute doxorubicin toxicity differentially alters cytochrome P450 expression and arachidonic acid metabolism in rat kidney and liver 显示文摘 | Zordoky BN Anwar AM Aboutabl ME | 2011 | Drug Metab Dispos2011，39，8： | 1 |
| 19 | Phytochemical and pharmacological studies on Leonotis leonurus显示文摘 | EL-ANSARI M A ABOUTABL E A FARRAG A R H | 1991 | Pharmaceutical Biology1991，47，： | 1 |
| 20 | Iridoids fromPhlomis aurea- decne growing in Egypt显示文摘 | Aboutabl E A Meselhy M R Afifi M S | 2002 | Pharmazie2002，57，9： | 1 |
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