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| 1 | Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer显示文摘AIM: To assess the proteome of normal versus tumor tissue in squamous cell carcinoma of the esophagus (SCCE) in Iranian patients and compare our results with former reports by using proteomics. METHODS: Protein was extracted from normal and tumor tissues. Two dimensional electrophoresis was carried out and spots with differential expression were identified with mass spectrometry. RNA extraction and RT-PCR along with immunodetection were performed. RESULTS: Fourteen proteins were found whose expression levels differed in tumor compared to normal tissues. Mass spectrometric analysis resulted in the identification of β-tropomyosin (TMβ), myosin light chain 2 (and its isoform), myosin regulatory light chain 2, peroxyredoxin 2, annexinⅠand an unknown polypeptide as the down regulated polypeptides in tumor tissue. Heat shock protein 70 (HSP70), TPM4-ALK fusion oncoprotein 2, myosin light polypeptide 6, keratinⅠ, GH16431p and calreticulin were the up-regulated polypeptides found in tumor tissue. Several of these proteins, such as TMβ,HSP70, annexinⅠ, calreticulin, TPM4-ALK and isoforms of myosins, have been well recognized in tumorigenesis of esophageal or other types of cancers. CONCLUSION: Our study not only supports the involve- ment of some of the formerly reported proteins in SCCE but also introduces additional proteins found to be lost in SCCE, including TMβ. | Ferdous Rastgar Jazii Zahra Najafi Reza Malekzadeh Thomas P Conrads Abed Ali Ziaee Christian Abnet Mansour Yazdznbod Ali Asghar Karkhane Ghasem H Salekdeh | 2006 | World Journal of Gastroenterology2006，12，44： | 14 |
| 2 | Diet and Upper Gastrointestinal Malignancies显示文摘 | Christian C. Abnet Douglas A. Corley Neal D. Freedman Farin Kamangar | 2015 | Gastroenterology2015，，： | 2 |
| 3 | Variants of the IL8 and IL8RB genes and risk for gastric cardia adenocarcinoma and esophageal squamous cell carcinoma 显示文摘 | Savage SA Abnet CC Mark SD | 2004 | Cancer Epidemiol Biomarkers Prey2004，13，12： | 1 |
| 4 | A prospective study of tobacco, alcohol, and the risk of esophageal and gastric cancer subtypes显示文摘 | Freedman N D Abnet C C Leitzmann MF | 2007 | Am J Epide- miol2007，165，12： | 1 |
| 5 | A prospectivestudy of tobacco,alcohol,and the risk of esophageal and gastriccancer subtypes 显示文摘 | Freedman ND Abnet CC Leitzmann MF | 2007 | AM J Epidemiol2007，165，12： | 1 |
| 6 | Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China显示文摘 | Tran GD Sun XD Abnet CC | 2005 | Int J Cancer2005，113，3： | 1 |
| 7 | Prospective study of tooth loss and incidentesophageal and gastric cancers in China显示文摘 | Qiao YL Mark SD | 2001 | Cancer Causes Control2001，12，： | 1 |
| 8 | Control region mutatlons and the 'common deletion' are frequent in the mitochondrial DNA of patients with esophageal squamous cell carcinoma 显示文摘 | ABNET CC HUPPI K CARRERA A | 2004 | BMC Cancer2004，4，1： | 1 |
| 9 | Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China显示文摘 | Tran G D Sun X D Abnet C C | 2005 | Int J Cancer2005，113，3： | 1 |
| 10 | Association ofcoffee drinking with total and cause-specific mortality 显示文摘 | Freedman ND Park Y Abnet CC | 2012 | N Engl J Med2012，366，20： | 1 |
| 11 | A prospective study of tobacco, alcohol, and the risk of esophageal and gastric cancer subtypes显示文摘 | Freedman ND Abnet CC Leitzmann MF | 2007 | AM J E pidemiol2007，165，： | 1 |
| 12 | A shared susceptibility locus inPLCE1 at 10q23 for gastric adenocarcinoma and esophageal squa-mous cell carcinoma 显示文摘 | Abnet CC Freedman ND | 2010 | Nature Genetics2010，42，9： | 1 |
| 13 | A shared susceptibility locus in PLCE1 at 10q23 for gastric adeno- carcinoma and esophageal squamous cell carcinoma 显示文摘 | Christian C Abnet Neal D Freedman Nan Hu | 2010 | Nat Genet2010，42，9： | 1 |
| 14 | Two forms of aryl hydrocarbon receptor type 2 in rainbow trout(Oncorhynchus mykiss)evidence for differential expression and enhancer specificity显示文摘 | Abnet C C Tanguay R L Hahn M E | 1999 | Journal of Biological Chemistry1999，274，15： | 1 |
| 15 | Interleukin-lB polymorphisms and gastric cancer risk--a meta-analysis 显示文摘 | Kamangar F Cheng C Abnet CC | 2006 | Cancer Epidemiol Biomarkers Prev2006，15，10： | 1 |
| 16 | Promoter methylation in cytology specimens as an early detection marker for esophageal squamous dysplasia and early esophageal squamous cell carcinoma显示文摘 | Adams L Roth MJ Abnet CC | 2008 | Cancer Prev Res (Phila)2008，1，5： | 1 |
| 17 | Promoter methylation in cytology specimens as an early detection marker for esophageal squamous dysplasia and early esophageal squamous cell carcinoma显示文摘 | Adams L Roth MJ Abnet CC | 2008 | Cancer Prev Res(Phila)2008，1，5： | 1 |
| 18 | Circulating 25-hydroxyvitamin D and risk of esophageal and gastric cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers显示文摘 | Abnet CC Chen Yu Chow WH | 2010 | Am J Epidemiol2010，172，1： | 1 |
| 19 | Histological precursors of oesophageal squamous cell carcinoma: results from a 13 year prospective follow up study in a high risk population显示文摘 | Wang G Q Abnet C C Shen Q | 2005 | Gut2005，54，： | 1 |
| 20 | A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma显示文摘 | Abnet CC Freedman ND Hu N | 2010 | Nat Genet2010，42，9： | 1 |
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