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| 1 | Bacteriophage secondary infection显示文摘Phages are credited with having been first described in what we now, officially, are commemorating as the 100 th anniversary of their discovery. Those one-hundred years of phage history have not been lacking in excitement, controversy, and occasional convolution. One such complication is the concept of secondary infection, which can take on multiple forms with myriad consequences. The terms secondary infection and secondary adsorption, for example, can be used almost synonymously to describe virion interaction with already phage-infected bacteria, and which can result in what are described as superinfection exclusion or superinfection immunity. The phrase secondary infection also may be used equivalently to superinfection or coinfection, with each of these terms borrowed from medical microbiology, and can result in genetic exchange between phages, phage-on-phage parasitism, and various partial reductions in phage productivity that have been termed mutual exclusion, partial exclusion, or the depressor effect. Alternatively, and drawing from epidemiology, secondary infection has been used to describe phage population growth as that can occur during active phage therapy as well as upon phage contamination of industrial ferments. Here primary infections represent initial bacterial population exposure to phages while consequent phage replication can lead to additional, that is, secondary infections of what otherwise are not yet phage-infected bacteria. Here I explore the varying meanings and resultant ambiguity that has been associated with the term secondary infection. I suggest in particular that secondary infection, as distinctly different phenomena, can in multiple ways influence the success of phage-mediated biocontrol of bacteria, also known as, phage therapy. | Stephen T Abedon | 2015 | Virologica Sinica2015,30,1: | 2 |
| 2 | Phage treatment of human infections 显示文摘 | Abedon ST Kuhl SJ Blasdel BG Kutter EM | 2011 | Bacteriophage2011,1,2: | 1 |
| 3 | Phage treatment of human infections显示文摘 | Abedon S T Kuhl S J Blasdel B G | 2011 | Bacteriophage2011,1,2: | 1 |
| 4 | Phage cocktails and the future of phage therapy 显示文摘 | Chan BK Abedon ST Loc-Carrilo C | 2013 | Future Microbiol2013,8,6: | 1 |
| 5 | Phage cocktails and the future of phage therapy显示文摘 | Chan BK Abedon ST Carrillo CL | 2013 | Future Microbial2013,8,: | 1 |
| 6 | Developmental changes associated with divergent selection for rind penetrometer resistance in the MoSCSSS maize synthetic显示文摘 | Abedon B G Darrah L L Tracy W F | 1999 | Crop Science1999,39,: | 1 |
| 7 | Bacteriophage prehistory:Is or is not Hankin,1896,a phage reference?显示文摘 | Abedon S T Thomas-Abedon C Thomas A | 2011 | Bacteriophage2011,1,3: | 1 |
| 8 | Lysis from without显示文摘 | Abedon ST | 2011 | Bacteriophage2011,1,1: | 1 |
| 9 | Phage treatment of Bob G Blas human infec tions显示文摘 | Stephen del et T Abedon Sarah J Kuhl al | 2011 | Bacteriophage2011,1,2: | 1 |
| 10 | Phage cocktails and the fu- ture of phage therapy显示文摘 | Chan B K Abedon S T Loc-Carrillo C | 2013 | Future Microbiol2013,8,6: | 1 |
| 11 | Phage treatment of hu- man infections显示文摘 | Abedon ST Kuhl SJ Blasdel BG | 2011 | Bacteriophage2011,1,2: | 1 |
| 12 | Pros and cons of phage therapy显示文摘 | Loc-Carrillo C Abedon S T | 2011 | Bacteriophage2011,1,2: | 1 |
| 13 | Bacteriophages and their enzymes in biofilmcontrol显示文摘 | Chan BK Abedon ST | 2014 | Curr Pharm Des2014,21,1: | 1 |
| 14 | Phage treatment of human infections显示文摘 | Abedon ST Kuhl SJ Blasdel BG | 2011 | Bacteriophage2011,1,: | 1 |
| 15 | Phage cocktails and the future of phage therapy显示文摘 | Chan BK Abedon ST Loc-Carrillo C | 2013 | Future Microbiol2013,8,: | 1 |
| 16 | Phage Treatment of human infections 显示文摘 | Abedon ST Kuhn SJ Blasdel BG | 2011 | Bacteriophage2011,1,2: | 1 |
| 17 | Phage treatment of human infections 显示文摘 | Abedon S T Kuhl S J Blasdel B G | 2011 | Bacteriophage2011,1,: | 1 |
| 18 | Pros and cons of phage therapy显示文摘 | LOC-CARRILLO C ABEDON S T | 2011 | Bacteriophage2011,1,2: | 1 |
| 19 | Bacteriophage host range and bacterial resistance 显示文摘 | Hyman P Abedon ST | 2010 | Adv Appl Microbiol2010,,70: | 1 |
| 20 | Chapter 1-phage therapy pharmacol-ogy :phage cocktails显示文摘 | Chan B K Abedon S T | 2012 | Advances in Applied Microbiology2012,78,: | 1 |